Clinical trials: Type 1 Diabetic Nephropathy
Diabetic Kidney Disease, Diabetic Nephropathy
Effect of LIXIsenatide on the Renal System
Based on preclinical and small-sized studies in non-diabetic individuals, incretin-based therapies, i.e. glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, may hold promise in preventing the…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathy, Diabetes Mellitus, Glucagon-Like Peptide 1
- Trial name
- ELIXIRS (NCT02276196)
- Testing
- Lixisenatide, Insulin glulisine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
In type 1 diabetes (T1DM), automated insulin delivery (AID) systems such as the hybrid closed loop artificial pancreas (HCL AP) combine the use of an insulin pump, continuous blood sugar monitor, and control algorithm to adjust…
- Conditions
- Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1, Autoimmune Diabetes, Juvenile Diabetes
- Trial name
- MERMAID-T1D (NCT03945747)
- Testing
- Blood draw, Urine sample collection, DXA scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Hypertension
Study of 24 Hour Blood Pressure and the Association to Complications to Type 1 Diabetes
The aim of the study is to evaluate the prevalence of abnormal nocturnal blood pressure (BP) in patients with type 1 diabetes. The investigators wish to gain knowledge on the relation between central and peripheral 24 hour BP and…
- Trial name
- PROFIL (NCT01171248)
- Where
- Denmark
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetic Nephropathies
A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes
Diabetic kidney disease remains the leading cause of end-stage kidney disease (ESKD), rising in frequency in parallel with the epidemic of diabetes worldwide.
- Trial name
- PERL-FENO (NCT04929379)
- Testing
- Fenofibrate
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Alessandro Doria
Cardiovascular Disease, Diabetic Nephropathy
Effect of a Vitamin D Analogue vs Placebo on p-NT-proBNP in Patients With Type 1 DM and Diabetic Nephropathy
The primary objective is to assess the impact of three months of treatment with an active vitamin D analogue on a risk marker for excess overall mortality and cardiovascular morbidity/mortality in Type 1 diabetic patients with…
- Trial name
- NCT01331317
- Testing
- Paricalcitol
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Peter Rossing
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Effect of Dietary Protein Restriction on Prognosis in Patients With Diabetic Nephropathy
The purpose of the investigators study was to determine the effect of dietary protein restriction on survival and progression to end stage renal disease (ESRD) in diabetic nephropathy.
- Trial name
- LPD (NCT01521910)
- Testing
- low protein diet, normal protein diet
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Diabetic Nephropathy
Phase 1 Study of FG-3019 in Subjects With Type 1 or Type 2 Diabetes Mellitus and Diabetic Nephropathy
The purpose of this study is to evaluate the safety and tolerability of two dosing regimens of FG-3019 administered over 12 weeks in patients with diabetic nephropathy and proteinuria on background angiotensin converting enzyme…
- Trial name
- NCT00754143
- Testing
- FG-3019
- Where
- 18 sites in United States
- Volunteers
- 38 people
- Sponsor
- Kyntra Bio
Hypertension, Diabetic Nephropathies
A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy (AMADEO Study)
A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes, high blood pressure, and kidney disease.
- Trial name
- NCT00168857
- Testing
- telmisartan, losartan
- Where
- 109 sites in United States, Argentina and 8 more
- Volunteers
- 860 people
- Sponsor
- Boehringer Ingelheim
Nephropathy, Diabetic Nephropathies
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
Background: Sodium-glucose-cotransporter (SGLT) inhibition has been observed to reduce risk of cardiovascular events and kidney failure in persons with type 2 diabetes.
- Conditions
- Nephropathy, Diabetic Nephropathies, Diabetes Mellitus, Type 1, Albuminuria
- Trial name
- PLUTO (NCT06147232)
- Testing
- Sotagliflozin
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 69 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetic Nephropathy, Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN)
This is a prospective open labeled trial examining the efficacy of ACTHar Gel (porcine ACTH) on the level of proteinuria in patients with diabetic nephropathy and nephrotic range proteinuria.
- Trial name
- ACTH-NRDN (NCT01028287)
- Testing
- ACTH
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Southeast Renal Research Institute
Diabetic Kidney Disease, Type 1 Diabetes
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
The primary objective of this study is to determine the effects of semaglutide on change in albuminuria from baseline to 26 weeks in type 1 diabetes.
- Trial name
- RT1D (NCT05822609)
- Testing
- Semaglutide
- Where
- 4 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- University of Washington
Type 1 Diabetes, Oxidative Stress
Role of Carnosine as an Adjuvant Therapy for Diabetic Nephropathy in Pediatrics With Type 1 Diabetes
Carnosine, a naturally-occurring dipeptide (β-alanyl-L-histidine) first described in 1900 by Gulewitsch and Amiradzibi, is found predominantly in post-mitotic tissues (e.g. brain and innervated muscle) of vertebrates .
- Conditions
- Type 1 Diabetes, Oxidative Stress, Carnosine, Diabetic Nephropathy
- Trial name
- NCT02928250
- Testing
- Carnosine
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320060
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 128 people
- Sponsor
- BioStratum
Type 1 Diabetes, T1D Heart Failure
Precision T1D Platform - New Therapies for Cardio-Renal Complications
Breakthrough T1D has awarded support for a joint University of Michigan-Oregon Health \& Science University Center of Excellence (CoE) to address cardio-renal complications in T1D.
- Conditions
- Type 1 Diabetes, T1D Heart Failure, Cardio-renal Vascular Function and Failure, Diabetic Chronic Kidney Disease
- Trial name
- NCT07594145
- Testing
- Finerenone, Sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Alpha-lipoic Acid in Diabetic Nephropathy
Endothelial dysfunction in diabetes is a central event in the pathogenesis of different microangioapthic changes. Nephropathy in patients with type 1 diabetes is a severe microvascular complication.
- Trial name
- NCT06253429
- Testing
- Thioctic Acid 333 MG Oral Capsule, Captopril 25Mg Tab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Bariatric Surgery Candidate
Paraoxonase and HDL Qualities in Glycaemia and Inflammation
The incidence of coronary heart disease (CHD) is significant in the super-obese and diabetics. Inflammation is believed to play an important part in the development of CHD, and the large collection of abdominal fat in the obese…
- Trial name
- PON1 (NCT02169518)
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Diabetic Nephropathies, Coronary Artery Disease
A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes
Despite improvements during the past 20 years in blood glucose and blood pressure control, diabetic kidney disease remains one of the most important causes of health problems in patients with diabetes.
- Trial name
- NCT02017171
- Testing
- Allopurinol
- Where
- 30 sites in United States, Canada and 1 more
- Volunteers
- 530 people
- Sponsor
- Alessandro Doria
Type 1 Diabetic Nephropathy
The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, affecting 25 to 40% of patients with type 1 diabetes (T1DM).
- Trial name
- NCT06115460
- Testing
- oral sitagliptin supplementation
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
The MICRON Study - A Steno 1 Substudy
The goal of this observational study is to compare cardiac and renal oxygen consumption among subjects with type 1 diabetes treated with either multifactorial intervention or according to the current standard care.
- Trial name
- MICRON (NCT07270172)
- Where
- 5 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus