Clinical trials: Type 2 Diabetes Mellitus With Complication
Type II Diabetes Mellitus, Gestational Diabetes Mellitus
Intrapartum Glycemic Control With Insulin Infusion Versus Rotating Fluids
This study will determine whether rotating intravenous (IV) fluid is better than receiving insulin to control a baby's blood sugar after delivery in laboring women with diabetes.
- Trial name
- NCT03912363
- Testing
- Rotating fluids protocol, Insulin infusion protocol
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Type II Diabetes Mellitus
A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Asian Diabetes Patients
To compare the efficacy and safety of ASP1941 + metformin with metformin alone in Asian subjects with type 2 diabetes mellitus.
- Trial name
- NCT01505426
- Testing
- ASP1941, metformin
- Where
- 12 sites in South Korea, Taiwan
- Volunteers
- 171 people
- Sponsor
- Astellas Pharma Inc
Kidney Failure, Hemodialysis
SGLT2 Inhibition in Hemodialysis
Dapagliflozin will be compared with placebo to evaluate its effects on cardiac structure and safety in patients with kidney failure receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Hemodialysis, Diabetes Mellitus, Type 2, Chronic Kidney Disease
- Trial name
- DAPA-HD (NCT05179668)
- Testing
- Dapagliflozin 10 MG
- Where
- 9 sites in Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Type 2, Preterm Birth
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Preterm Birth, Pregnancy, High Risk, Diabetes, Gestational
- Trial name
- NCT04542148
- Testing
- Sliding Scale Insulin, Up-Titration of Home Insulin, Continuous Insulin Infusion
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Complications, Diabetes Mellitus, Type 2
A Pilot Intervention Study of Health Coaching to Promote Diabetes Self-Care in the Community
Diabetes poses a substantial burden to racial/ethnic minorities and in populations with limited access to healthcare. However, there is a shortage of healthcare providers available to help patients adopt the lifestyle changes…
- Trial name
- C4C (NCT01695278)
- Testing
- Telephone Counseling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwestern University
Type 2 Diabetes
Improving Risk Factors for Diabetes Complications in Primary Care
The purpose of this study is to test an intervention in primary care clinics to improve three risk factors for diabetes complications: glucose control, blood pressure and cholesterol.
- Trial name
- NCT00482768
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 2,493 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetic Nephropathy, Diabetic Kidney Disease
Pyridorin in Diabetic Nephropathy
The purpose of this study is to evaluate the safety and efficacy of oral Pyridorin 300 mg BID in reducing the rate of progression of nephropathy due to type 2 diabetes mellitus.
- Trial name
- PIONEER (NCT02156843)
- Testing
- Pyridorin
- Where
- 137 sites in United States, Australia and 10 more
- Volunteers
- 328 people
- Sponsor
- NephroGenex, Inc.
Diabetes-Related Complications
Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression
The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence.
- Trial name
- SBDD (NCT06979440)
- Testing
- No intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Nantong University
Type 2 Diabetes Mellitus
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent…
- Trial name
- R2D2 (NCT01536808)
- Testing
- Cardiac RMI, Analysis telomere, Stress test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy
Remote Ischemic Conditioning for Non-Proliferative Diabetic Retinopathy
The goal of this clinical trial is to evaluate whether remote ischemic conditioning (RIC) is a safe and effective treatment for non-proliferative diabetic retinopathy (NPDR) in adults aged 40-80 years with type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy, Remote Ischemic Conditioning, Diabetes Mellitus, Type 2
- Trial name
- RIC-NPDR (NCT06713720)
- Testing
- Remote Ischemic Conditioning Device
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- Xuxiang Zhang, MD
Type 2 Diabetes Mellitus (T2DM)
Effect of Digital-Supported Foot Care Education in Individuals With Type 2 Diabetes
This randomized controlled trial will evaluate the effect of digital-supported foot care education on foot care knowledge, self-care behaviors, and self-efficacy in individuals with type 2 diabetes.
- Trial name
- NCT07813676
- Testing
- Digital-Supported Foot Care Education
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Siirt University
Diabetes Mellitus Type 2, End Stage Renal Disease
Surrogate Markers for Sudden Cardiac Death in Patients With Diabetes Mellitus and End Stage Renal Disease
Aim: Patients with type 2 diabetes mellitus (T2DM) and hemodialysis due to diabetic nephropathy exhibit a high risk for sudden cardiac death (SCD).
- Trial name
- NCT02001480
- Testing
- 12 lead Holter, CGM Continuous Glucose Monitoring
- Where
- 3 sites in Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Diabetic Foot Ulcer, Type 2 Diabetes Mellitus With Complication
Implementation of a Preventive Diabetic Foot Care Program for Patients at Risk of Diabetic Foot
This study aims to evaluate the effect of a preventive diabetic foot care program on the knowledge, behavior, self-management, and glycemic control levels of type 2 diabetic patients at risk of diabetic foot.
- Trial name
- NCT06770829
- Testing
- DiaFOOTCare Program, Ministry of Health and Education
- Volunteers
- 78 people
- Sponsor
- Akdeniz University
Diabetic Retinopathy
Correlation Between HBA1c Level and Thickness of Both Macula and Choroid in Patients With Type 2 Diabetes Mellitus
Diabetic retinopathy (DR) is a frequent cause of visual impairment, and the leading cause of blindness in those of working age, but it develops silently along years, producing symptoms only in late stages.
- Trial name
- NCT05778370
- Testing
- Swept Source Optical Coherence Tomography(Topcon DRI Triton)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Olmesartan Medoxomil and Diabetic Nephropathy
Evaluation of several olmesartan dosages compared to losartan on proteinuria, renal function and inflammatory markers in patients with diabetic nephropathy
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Nephropathy, Proteinuria, Renal Disease
- Trial name
- NCT00362960
- Testing
- Olmesartan medoxomil, Losartan
- Where
- 27 sites in Czechia, Estonia and 5 more
- Volunteers
- 300 people
- Sponsor
- Sankyo Pharma Gmbh
Type 2 Diabetes Mellitus, Renal Impairment
Gla-300 and IDeg-100 in Insulin-Naïve People With Type 2 Diabetes Mellitus and Renal Impairment
The TRENT trial is designed to confirm the efficacy and safety of Gla-300 compared with IDeg-100 in insulin-naïve patient (participants who have not tried insulin) with Type 2 Diabetes Mellitus (T2DM) and renal impairment.
- Trial name
- TRENT (NCT05552859)
- Testing
- Insulin glargine 300 U/mL, Insulin degludec 100 U/mL
- Where
- 68 sites in United States, Czechia and 3 more
- Volunteers
- 62 people
- Sponsor
- Sanofi
Type2 Diabetes Mellitus
Web-based Diabetic Foot Care Training Prepared With the Health Belief Model for Type 2 Diabetes Patients
Diabetes Mellitus (DM), insulin secretion, insulin action or this It is a chronic metabolic disease characterized by hyperglycemia caused by a defect in both of these factors.
- Trial name
- dabe (NCT05395442)
- Testing
- Training on web-based diabetic foot care based on the Health Belief Model
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Yuzuncu Yil University
Type 2 Diabetes Mellitus, Nephropathy
Probucol Combined With Valsartan in Reducing Proteinuria in Diabetes Nephropathy
This is a prospective randomized controlled, open-labeled study to identify the efficacy of probucol in combination with valsartan in patients with Diabetes nephropathy.
- Trial name
- NCT00655330
- Testing
- Valsartan, Probucol
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Guangdong Provincial People's Hospital
Type 2 Diabetes Mellitus, Chronic Kidney Disease
A Study to Learn More About Chronic Kidney Disease (CKD) in Patients With Type 2 Diabetes Mellitus (T2DM)
In this observational study, data from the recent past of patients with type 2 diabetes mellitus and chronic kidney disease will be studied.
- Trial name
- CKD-T2DM (NCT05004428)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 336,376 people
- Sponsor
- Bayer