Clinical trials: Ultrasonography, Doppler, Transcranial
Aortic Stenosis
Microembolic Signals and Serum Markers of Neuronal Damage During Transcatheter Aortic Valve Implantation.
Transcatheter Aortic Valve Implantation (TAVI) using femoral access is an option for definitive treatment of aortic stenosis when open-heart surgery is considered inappropriate.
- Trial name
- NCT01237743
- Testing
- Transcatheter aortic valve implantation.
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Sahlgrenska University Hospital
Minimal Hepatic Encephalopathy
Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy
Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact. Thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected…
- Trial name
- NCT04077125
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
Sonolysis in Risk Reduction of Symptomatic and Silent Brain Infarctions During Coronary Stenting
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- NCT02351050
- Testing
- Sonolysis
- Where
- Slovakia
- Volunteers
- 144 people
- Sponsor
- University Hospital Ostrava
Right-to-left Shunt, Migraine
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Conditions
- Right-to-left Shunt, Migraine, Cerebral Infarction
- Trial name
- NCT02425696
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Yingqi Xing
Carotid Artery Stenosis, Ischemic Stroke
Platelet Reactivity and MES During CEA
The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).
- Conditions
- Carotid Artery Stenosis, Ischemic Stroke, Myocardial Infarction, Aspirin Resistance
- Trial name
- NCT01547039
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Trauma, Brain
Transcranial Doppler in Mild and Moderate Traumatic Brain Injury (TBI)
Utility of transcranial Doppler as an Early Predictor of Neurological deterioration in Mild and Moderate Traumatic Brain Injury
- Trial name
- NCT05151978
- Testing
- Transcranial Doppler
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Postoperative Delirium After On-pump Cardiac Surgery
Preoperative Transcranial Doppler as a Predictor for Delirium Following On-pump Cardiac Surgery
Postoperative delirium is an important problem in patients undergoing major cardiac surgery and associated with more complicated hospital course, increased hospital length of stay and total postoperative cost.
- Trial name
- NCT02478736
- Testing
- No actual intervention
- Where
- South Korea
- Volunteers
- 175 people
- Sponsor
- Yonsei University
Obesity, Cerebrovascular Function
Respiratory Muscle Training to Improve Cerebrovascular and Immune Function
Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively.
- Conditions
- Obesity, Cerebrovascular Function, Immune Cells Activity
- Trial name
- NCT07406295
- Testing
- High intensity inspiratory muscle strength training, Low intensity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Sickle Cell Disease, Stroke
Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the Community
The overall goal of this feasibility study is to establish a standard of care stroke prevention program for children with sickle cell anemia in a community hospital by task shifting stroke detection and transcranial Doppler…
- Trial name
- SPRING-COM (NCT05434000)
- Testing
- Hydroxyurea
- Where
- Nigeria
- Volunteers
- 217 people
- Sponsor
- Barau Dikko Teaching Hospital
Traumatic Brain Injury
TCD and ONSD for Early Risk Stratification of Traumatic Brain Injury
This observational study aims to evaluate the combined use of transcranial Doppler (TCD) and optic nerve sheath diameter (ONSD) ultrasound for early risk stratification of adults with traumatic brain injury (TBI) presenting to…
- Trial name
- TCD-ONSD (NCT07820527)
- Testing
- Transcranial Doppler and Optic Nerve Sheath Diameter Assessment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage
Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.
- Trial name
- Decibel (NCT07305922)
- Testing
- Induced hypertension with norepinephrine, Endoluminal Spasmolysis
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Carotid Stenosis
Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery
As with coronary artery stenting, activation and embolisation of platelets occurs with carotid artery stenting (CAS). Based on promising data on the use of clopidogrel plus aspirin in coronary stenting this dual antiplatelet…
- Trial name
- IMPACT (NCT01146301)
- Testing
- Clopidogrel
- Where
- Netherlands
- Sponsor
- R&D Cardiologie
Liver Transplantation
Incidence of Intracranial Hypertension During Liver Transplantation Estimated by Non-invasive Ultrasound Methods.
Acute or chronic liver failure (fulminant hepatitis or advanced cirrhosis) disrupts brain physiology. Beyond classical hepatic encephalopathy, intracranial hypertension may occur.During liver transplantation (LT) surgery, many…
- Trial name
- TOH-HTIC (NCT02695823)
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Liver Failure, Acute, Hepatic Encephalopathy
Neuromonitoring of Hepatic Encephalopathy
Neuromonitoring of critically ill patients in the intensive care unit (ICU) is challenging. Clinical scoring systems produce insufficient information with deeply sedated patients, and disturbances of normal hemostasis limit the…
- Trial name
- NCT01878305
- Testing
- Molecular Adsorbent Recirculating System (MARS)
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Helsinki
Stroke
Reproducibility Study of Transcranial Doppler
Hardening of the neck vessels (carotid arteries) caused by fatty deposits called 'plaques' is a common cause of strokes. Over time plaques can burst or may lead to a severe narrowing (stenosis) of the neck artery.
- Trial name
- NCT03050567
- Testing
- Transcranial Doppler Ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
Vertebrobasilar Insufficiency
Clinical and Radiological Evaluation of Patients With Vertebrobasilar Insufficiency in Assiut University Hospital
Clinical and radiological evaluation including transcranial Doppler of vertebral arteries of patients with vertebrobasilar insufficiency attending assiut university hospital and assessment of possible risk factors that may lead…
- Trial name
- NCT05019391
- Testing
- transcranial doppler
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
Head Injury
Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test (Galvestone Orientation Amnesia Test), TC image (Marshall Scale) and prognosis (DRS and GOS) in…
- Trial name
- NCT00353444
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Stroke, Acute, Vessels; Occlusion
Blood Pressure Management in Stroke Following Endovascular Treatment
The aim of DETECT is to prove the feasibility of a multicenter phase III trial testing the hypothesis that intensive blood pressure control immediately after successful endovascular stroke thrombectomy can improve patient…
- Conditions
- Stroke, Acute, Vessels; Occlusion, Blood Pressure, Endovascular Thrombectomy
- Trial name
- DETECT (NCT04484350)
- Testing
- Labetalol, Hydralazine, Enalapril
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation