Clinical trials: Uncertainty
Anxiety
Uncertainty and Firearms: Obtaining Secure Storage
The goal of this clinical trial is to test whether inclusion of cognitive behavioral therapy (CBT) for Uncertainty-Enhanced (CUE) with Lethal Means Counseling (LMC) is acceptable, feasible, and efficacious in addressing secure…
- Trial name
- UFOS (NCT05818696)
- Testing
- Lethal Means Counseling (LMC), CBT for Uncertainty - Enhanced (CUE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Psychiatric Nursing, Schizophrenia
The Effect of Psychoeducation Based on Uncertainty In Illness Theory On Schizophrenia Caregivers
The purpose of this study is to determine the effect of the psychoeducation program based on the Uncertainty in Illness Theory on intolerance to uncertainty, psychological well-being and coping styles of caregivers of…
- Trial name
- NCT04822051
- Testing
- The Uncertainty Management Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Parkinson's Disease, Dystonia
Perceptual Decision Making Under Conditions of Visual Uncertainty
In this proposal the investigators have three Specific Aims using human patient populations as model systems; 1) identify a role for the Basal Ganglia (BG) in perceptual decision making; 2) determine whether the Basal Ganglia…
- Conditions
- Parkinson's Disease, Dystonia, Ataxia
- Trial name
- NCT01845883
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Physician Patient Relationship
Randomized Controlled Trial Assessing the Efficacy of a Communication Skills Training Program
Background: Although previous studies have reported the efficacy of communication skills training programs (CST), specific training addressing communication about uncertainty and hope in oncology has not yet been studied.
- Trial name
- CERTAIN (NCT02836197)
- Testing
- Communication skills training
- Where
- 2 sites in Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jules Bordet Institute
I) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS)
Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer
This study compares how effective is the molecular screening (a blood test) using Pap smear as reference, that is, a comparison of these tests abilities to detect precursor lesions and cervical cancer among women of an open…
- Conditions
- I) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS), III) Cervical Intraepithelial Neoplasia (CIN), CIN-1, CIN-2, CIN-3, IV) Low-grade Squamous Intraepithelial Lesion (LSIL)
- Trial name
- NCT07480902
- Testing
- Physical examination, Liquid-based cytology, Molecular screening
- Where
- Mexico
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Timser SAPI de CV
HNPCC
Uncertain Genetic Test Results for Lynch Syndrome
Background: Individuals have varying tolerances for receiving ambiguous information. However, not much is known about how ambiguous genetic testing information is received.
- Trial name
- NCT01646112
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Diagnoses Disease
GP Response to Decontextualised Risk
Decontextualised risk information is any information pertaining to diagnosis, which is introduced into a clinical consultation, or a diagnostic thought process, without being requested by the clinician.
- Trial name
- NCT05399511
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Follow-up After Uterine Evacuation
The Role of a Semi-Quantitative Urine Pregnancy Test and Pregnancy Questionnaire After Uterine Evacuation for Undesired Pregnancy of Uncertain Location
The primary aim of this study is to determine if a self-administered semi-quantitative urine pregnancy test and telephone pregnancy symptom questionnaire can reduce the percentage of women with a complete uterine evacuation who…
- Trial name
- NCT01596972
- Testing
- dBest semi-quantitative urine pregnancy test
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Pulmonary Embolism, Diagnostic Uncertainty
The Visualization of Uncertainty in Clinical Diagnostic Reasoning for Pulmonary Embolism
Medical reasoning is a form of inquiry that examines the thought processes involved in making medical decisions. When physicians are faced with patients' symptoms or signs, their thought processes follow either direct shortcuts…
- Conditions
- Pulmonary Embolism, Diagnostic Uncertainty, Clinical Reasoning, Evidence Based Medicine
- Trial name
- NCT01752673
- Testing
- Visualized pulmonary embolism computer task model, Didactic review lecture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Inherited Cancer Syndrome, Prostate Cancer
Improving Care After Inherited Cancer Testing
The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented…
- Conditions
- Inherited Cancer Syndrome, Prostate Cancer, Colorectal Cancer, Endometrial Cancer
- Trial name
- IMPACT (NCT04763915)
- Testing
- Correlative Studies (Survey), Correlative Studies (Interview), GeneSHARE
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Health Behavior, Motivation
Measuring Anticipated Attitudes and Behavior Towards a New Medical Treatment in Lesotho
The primary research objective is to examine how uncertainty towards a new medical treatment changes in patients when a partner (can be any close other, i.e.
- Conditions
- Health Behavior, Motivation, Health Care Utilization, Consumer Behavior
- Trial name
- NCT06246058
- Testing
- Partner support, Formal recruiter attire, Without Partner support
- Where
- Lesotho
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infections
Validation of Betalactam ML Prediction Models - TDMAide
The goal of this study is to learn about the real wold behavior of developed machine learning models that predict the plasma concentration of piperacillin-tazobactam and meropenem in critically ill patients admitted to the…
- Trial name
- TDMAide (NCT06026852)
- Testing
- Prediction of plasma concentration of piperacillin-tazobactam or meropenem, Determination of plasma concentration of piperacillin-tazobactam or meropenem, Daily short questionnaire
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Skin Lesions
Human-AI Uncertainty Callibration for Improved Skin Lesion Segmentation
The goal of this randomized controlled study is to compare the effect of a new, personalized uncertainty-aware decision model (FDM) to a standard image recognition model in improving the diagnostic accuracy while reducing…
- Trial name
- NCT07468357
- Testing
- Base Model, FDM
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Intolerance to Uncertainty
The Effectiveness of Cognitive Bias Modification on Intolerance of Uncertainty
The current study aims to reduce the intolerance of uncertainty levels with an internet-based cognitive bias modification intervention in young adults with high levels of intolerance to uncertainty aged between 18 and 40.
- Trial name
- NCT06174311
- Testing
- Active Cognitive Bias Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
Multiple Sclerosis
Medical Education for Better Multiple Sclerosis Outcomes
The main objectives of this study are: i) To design an educational tool to train physicians in overcome cognitive factors associated with therapeutic inertia.
- Trial name
- EDUCAR MS (NCT03134794)
- Testing
- Educational intervention applying the traffic light system (TLS)
- Where
- 4 sites in Argentina, Canada and 2 more
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cancer
Communicating Uncertainties Associated With the Benefits and Risks of New Cancer Drugs
This nationally representative randomized survey of US adults will evaluate the effect of using brief statements to communicate different sources of uncertainty about the benefits and harms of new cancer drugs on participants'…
- Trial name
- NCT06997185
- Testing
- Statement communicating uncertainty with a single arm trial, Statement communicating uncertainty with limited study duration, Statement communicating uncertainty with a limited study population
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- London School of Economics and Political Science
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing…
- Trial name
- TENS (NCT06541015)
- Testing
- InTENSity 10 TENS Stimulator
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Arrest
fMRI in CardiaC arrEst With Uncertain Prognosis
The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest.
- Trial name
- FACE-UP (NCT06423768)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Anxiety
Pilot Study of an Extended CBT Group Intervention for Intolerance of Uncertainty
This study will examine the effect of cognitive-behavioral group psychotherapy, structured within the framework of ecological systems theory, on adults' intolerance of uncertainty.
- Trial name
- NCT07460479
- Testing
- Extended Cognitive-Behavioral Group Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University