Clinical trials: Uncomplicated Diverticular Disease
Diverticulum, Colon, Diverticulitis
Registro Malattia Diverticolare (Registry of Diverticular Disease)
To determine the clinical characteristics and risk factors for the onset of diverticular disease and its complications in the Italian population.
- Trial name
- REMAD (NCT03325829)
- Volunteers
- 1,217 people
- Sponsor
- Gruppo Italiano Malattia Diverticolare
Diverticular Disease, Symptomatic Uncomplicated Diverticular Disease
Lactoferrin for the Treatment of Symptomatic Uncomplicated Diverticular Disease
Diverticular disease is a chronic pathology, characterized by recurrent abdominal symptoms and a high social impact, with a high prevalence in developed countries, especially among the elderly.
- Trial name
- SUDDENLY (NCT03490279)
- Testing
- Lactoferrin CRX
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Diverticulitis
Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)
Curcumin (Cur), an active ingredient of the Indian herb Rhizoma Curcuma Longa, has been extensively studied in the context of inflammatory diseases.
- Trial name
- NCT05596214
- Testing
- Curcumin-Berberine (coptis)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Dr. Adi Lahat
Diverticulitis, Uncomplicated Diverticular Disease
FMT in Uncomplicated Diverticulitis
Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C.
- Trial name
- NCT05373784
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Justin Maykel
Diverticular Disease
Immunohistology in USDD and Correlation Between Bacterial Flora and Phlogosis
Diverticulosis of the colon is a frequent condition in adults in western countries and a significant number of patients experience clinical symptoms even when the diverticulosis is not complicated by diverticulitis.
- Trial name
- NCT02068482
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Catholic University of the Sacred Heart
Simple Diverticular Disease
Randomized Clinical Trial for the Uncomplicated Diverticulitis in Right Colon
The aim of the present study was to evaluate whether antibiotics is mandatory for the treatment of acute uncomplicated right-sided diverticulitis.
- Trial name
- NCT02314013
- Testing
- Cephalosporin + Metronidazole
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Dongtan Sacred Heart Hospital
Colonic Diverticulitis
Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis
The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.
- Trial name
- NCT01008488
- Testing
- Antibiotic
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center
Simple Diverticular Disease
Evaluation of the Metabolome in Diverticular Disease
To evaluate the effect of the probiotic formulation VSL#3 on the metabolome and microbiota of diverticular disease, comparing it with the effects exerted by supplementation with fibers, by rifaximin and by mesalazine, and…
- Trial name
- NCT01831323
- Testing
- VSL#3, Rifaximin, Mesalazine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- S.Eugenio Hospital
Colonic Diverticulitis
The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis
Previous multicentre study NCT 01008488 indicates that a patient with CT-proven uncomplicated diverticulitis has a very low risk (1.4%) of developing severe complications such as perforations or abscesses.
- Trial name
- P-VOD (NCT01515150)
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Uppsala University
Diverticulitis
Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary.
- Trial name
- AUD (NCT07824180)
- Testing
- standardized treatment algorithm
- Volunteers
- 800 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Diverticulitis, Colonic
Effectiveness and Safety of Outpatient Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics
The objective of this clinical trial to evaluate the effectiveness and safety of outpatient treatment without antibiotics compared to outpatient treatment with antibiotics in patients with acute uncomplicated diverticulitis.
- Trial name
- ADIANA (NCT06517264)
- Testing
- Antibiotic, Non antibiotic
- Where
- Spain
- Volunteers
- 282 people
- Sponsor
- Monica Mengual Ballester
Diverticular Diseases, Gastro-Intestinal Disorder
Clostridium Butyricum CBM588® vs. Rifaximin for Symptomatic Uncomplicated Diverticular Disease (SUDD): A Real-World Retrospective Study
This retrospective, real-world, single-center clinical study aimed to evaluate the effectiveness of probiotic Clostridium butyricum CBM588® (Butirrisan®) versus Rifaximin in the management of Symptomatic Uncomplicated…
- Trial name
- NCT06852274
- Testing
- Clostridium butyricum CBM588® (Butirrisan®), Rifaximin 400 mg Oral Tablet
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Dr. Amjad Khan
Uncomplicated Diverticular Disease
Outpatient Treatment of Uncomplicated Diverticulitis With Either Antibiotic or Nonantibiotic Treatment
Uncomplicated sigmoid diverticulitis is a common disease in Western countries. Traditional management includes inpatient administration of either oral or intravenous antibiotics with resumption of oral intake as symptoms improve.
- Trial name
- MUD (NCT03146091)
- Testing
- Nonantibiotic treatment of uncomplicated diverticulitis, Antibiotic treatment of uncomplicated diverticulitis
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Jewish General Hospital
Diverticulitis
Symptomatic Treatment of Acute Uncomplicated Diverticulitis
The purpose of this study is to determine the safety and efficacy of symptomatic treatment (i.e. without antimicrobial drugs) of acute uncomplicated diverticulitis.
- Trial name
- NCT02219698
- Testing
- Ibuprofen, Paracetamol
- Where
- Finland
- Volunteers
- 158 people
- Sponsor
- Helsinki University Central Hospital
Diverticulitis
Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute Diverticulitis
Medical treatment of uncomplicated acute diverticulitis is not standardized and there is an enormous diversity in clinical practice.
- Trial name
- DANC-05 (NCT00917592)
- Testing
- amoxicillin plus clavulanic acid
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Diverticulitis
Diverticulitis: Antibiotics or Close Observation?
Rationale The prevalence of colonic diverticular disease is increasing in Western countries. Approximately 10 to 25% of patients with diverticular disease will eventually develop an episode of acute diverticulitis.
- Trial name
- DIABOLO (NCT01111253)
- Testing
- Amoxicillin-clavulanate
- Where
- 24 sites in Netherlands
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colonic Diverticulosis
Mesalamine for Uncomplicated Diverticular Disease: a Randomized, Double-blind, Placebo-controlled Study
The purpose of this study is to determine whether mesalamine is effective in the treatment of uncomplicated diverticular disease by reducing the pain.
- Trial name
- NCT01627262
- Testing
- Mesalamine
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- Dr. Falk Pharma GmbH
Diverticulitis, Acute Diverticulitis
Randomized Multicentric Trial to Evaluate a Free Diet With a Progressive Diet in the Treatment of Acute Diverticulitis (DIVERDIET)
Phase III trial is designed to demonstrate the non-inferiority of a free diet versus a progressive diet in the treatment of acute diverticulitis (AD) without complications.
- Conditions
- Diverticulitis, Acute Diverticulitis, Diverticulitis, Colonic, Uncomplicated Diverticular Disease
- Trial name
- NCT03496090
- Testing
- Free diet, Progressive diet
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Hospital General Universitario Reina Sofía de Murcia
Diverticular Diseases
Effect of Nutritional Counseling and Mediterranean Diet on Patients With Diverticular Disease
Diverticular Disease (DD) is a frequent condition in Western populations and may be associated with complications including bleeding, perforation, acute diverticulitis, and colon strictures.
- Trial name
- Nutri-DICA (NCT06797739)
- Testing
- Nutritional counselling, Diet
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana