Clinical trials: Unipolar Disorder
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation
Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression
In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing.
- Conditions
- Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation, Accelerated Protocol, Intermittent Theta Burst Stimulation
- Trial name
- NCT07264452
- Testing
- Transcranial Magnetic Stimulation with figure-eight coil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Atrial Fibrillation, Arrhythmia
Unipolar Atrial Electrogram Modification Combined to the Contact Force Sensing Technology for Pulmonary Vein Isolation
Prospective observational multicentric study evaluating the efficacy of considering unipolar signal modification during radio frequency catheter ablation of patients with symptomatic paroxysmal atrial fibrillation in France…
- Trial name
- Uniforce (NCT02520960)
- Where
- France
- Volunteers
- 215 people
- Sponsor
- Hôpital Privé Les Franciscaines
Depression, Bipolar Disorder
Telemedicine for Women With Anhedonia in Bipolar and Unipolar Disorder
Anhedonia, characterized as (a) the diminished motivation to participate in activities, and/or (b) diminished enjoyment of a pleasurable activity are common symptoms among women diagnosed with mood disorders.
- Conditions
- Depression, Bipolar Disorder, Anhedonia
- Trial name
- NCT02494050
- Testing
- Behavioral Activation-Full, Behavioral Activation-Short, Bipolar Disorder Collaborative Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Atrial Fibrillation (AF), Atrial Fibrillation Patients Treated With the FARAPULSE™ PFA System
P-wave Duration and Local Potential as Predictors of AF Recurrence Following Pulmonary Vein Isolation
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia worldwide and is associated with substantial morbidity, mortality, and healthcare utilization.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Patients Treated With the FARAPULSE™ PFA System, Atrial Fibrillation (Paroxysmal), Pulmonary Vein Isolation
- Trial name
- FOLLOW-AF (NCT07471308)
- Testing
- AF Recurrence RIsk Assessment post pulmonary vein isolation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- CathVision ApS
Unipolar Depression
Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding
In treatment-resistant depression, electroconvulsive therapy (ECT) has been shown to effectively reduce depressive symptoms, though the underlying neurobiological mechanism is still unclear.
- Trial name
- NCT00922064
- Testing
- ECT
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Major Depression
Study of Depression-Ketamine-Brain Function
Targeting the glutamatergic system to treat depression is a new and promising strategy based on studies at the molecular, synaptic, and neuronal level but also on results of studies conducted in animal models and first clinical…
- Trial name
- NCT01135758
- Testing
- Ketamine
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Markus KOSEL
Unipolar Depression, Bipolar Depression
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.
- Trial name
- NCT07266545
- Testing
- Vortioxetine, Cariprazine (Augmentation Phase)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Unipolar Depression
Effects of Repeated Attachment Security Priming on Depressed Mood: a Clinical Study
The purpose of this study is to explore whether asking participants to visualise a secure attachment figure or a neutral event leads to differences in self-reported felt security or depressed mood.
- Trial name
- NCT01694030
- Testing
- Attachment security priming
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Southampton
Depression, Unipolar
Pulsed Electro Magnetic Fields (PEMF) in Depression
PEMF (Pulsed Electro Magnetic Fields) therapy has been used to stimulate bone repair in non-union since the 1970s. This is an accepted use, which has been approved by the Food and Drug Administration in the US.
- Trial name
- PEMF (NCT03556735)
- Testing
- Treatment with PEMF equipment
- Where
- Denmark
- Volunteers
- 59 people
- Sponsor
- University of Southern Denmark
Major Depressive Disorder, Anxiety
The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
The purpose of this study is to determine whether vilazodone is more effective than citalopram for the treatment of anxious depression.
- Conditions
- Major Depressive Disorder, Anxiety, Comorbidity
- Trial name
- NCT02028026
- Testing
- Vilazodone, Citalopram
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Unipolar Depression, Dysthymia
A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
The investigators are adapting Interpersonal Psychotherapy (IPT-A) for adolescents who are referred to emergency services either for a suicide attempt or for being evaluated as high risk for suicidal behavior.
- Trial name
- IPT-A-CSP (NCT01447602)
- Testing
- IPT-A
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Dysthymic Disorder
Cognitive Therapy for Unipolar Depression: Efficacy of a Dilemma-Focused Intervention
The purpose of this study is to determine the efficacy of a brief psychological intervention focused on the personal dilemmas identified for each depressive patient.
- Trial name
- NCT01542957
- Testing
- Combined Cognitive Behavioral and Dilemma-Focused Therapy, Cognitive Behavioral Therapy for Depression
- Where
- 4 sites in Spain
- Volunteers
- 128 people
- Sponsor
- University of Barcelona
Major Depressive Disorder
Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation
Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e.
- Trial name
- NCT02685982
- Testing
- Rhythmic Sensory Stimulation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Treatment-resistant Depression
Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression
Treatment resistant depression (TRD) is a frequent, debilitating condition mostly treated by antidepressants. Repeated magnetic transcranial stimulation (rTMS) has proven adjuvant efficacy in TRD in the acute phase of treatment…
- Trial name
- ACOUSTIM (NCT03701724)
- Testing
- Systematic maintenance rTMS, rTMS course in case of relapse
- Where
- 19 sites in France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
Unipolar Depression
Natural Supplements for Unipolar Depression
This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
- Trial name
- NCT00226356
- Testing
- Supplements of L-methionine, betaine and folate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Unipolar Depression
Randomized Clinical Trial of an Exposure-based Cognitive Therapy for Depression
The purpose of this study is to investigate, if exposure-based cognitive therapy (EBCT) is at least as effective as the established cognitive-behavioral therapy and more effective in its long-term efficacy.
- Trial name
- NCT01012856
- Testing
- Cognitive-Behavioral Therapy for Depression, Exposure-Based Cognitive Therapy for Depression
- Where
- Switzerland
- Volunteers
- 142 people
- Sponsor
- University of Zurich
Depression, Unipolar
Psychotherapy Feasibility Pilot of the Carolina Recovery From Depression Protocol
The goal of this clinical trial is to learn whether an single session intervention can reduce psychological impairment in adult individuals with moderate depression.
- Trial name
- CARED (NCT06590038)
- Testing
- Single Session Psychotherapy Intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health