Clinical trials: Unipolar Disorder
Depression, Mood Disorder
A Pharmacokinetic/Pharmacodynamic Genetic Variation Treatment Algorithm Versus Treatment As Usual for Management Of Depression
The overall goal of this investigator-initiated trial is to evaluate the treatment outcome of depression utilizing platform algorithm products that can allow rapid identification of pharmacokinetic (PK) and/or pharmacodynamic…
- Conditions
- Depression, Mood Disorder, Bipolar
- Trial name
- MOD (NCT02189057)
- Testing
- AssureRx GeneSight genotyping results, Treatment as usual
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Mayo Clinic
Depressive Disorder, Major
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
This is a randomised double-blind clinical trial. The aim is to compare the efficacy and mechanisms of action of psilocybin, the primary psychoactive substance in 'magic mushrooms', with the selective serotonin reuptake inhibitor…
- Trial name
- Psilodep-RCT (NCT03429075)
- Testing
- Psilocybin + Escitalopram
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Imperial College London
Atrial Fibrillation
Efficacy Rate of Unipolar Polarity Switch for Lesion Assessment in Pulmonary Vein Isolation
The technique of intraprocedural electrogram morphology as a measure of lesion effectiveness in an attempt to achieve durable PVI, clearly led to shortened procedural time, radiation exposure, and superiority in outcomes, with…
- Trial name
- NCT05464537
- Testing
- Unipolar Polarity Switch Left, Unipolar Polarity Switch Right
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Depressive Disorder, Depression
The Role of Inflammatory Processes in Development and Treatment of Depression
The study investigates the influence of inflammatory processes on the development and the course of uni- and bipolar depression.
- Conditions
- Depressive Disorder, Depression, Inflammation
- Trial name
- INFLAME-D (NCT03920475)
- Testing
- Sertraline or venlafaxine, Immune parameters
- Volunteers
- 104 people
- Sponsor
- Kliniken Essen-Mitte
Major Depressive Disorder, Unipolar Depression
Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder
This study evaluates the addition of light therapy with LUMINETTE device to usual treatment (antidepressant drug and psychotherapy) in the treatment of Major Depressive Disorder (MDD).
- Trial name
- LUMIDEP (NCT03685942)
- Testing
- active light therapy (LUMINETTE®)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Psychothérapique de Nancy
Depressive Disorder
Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression
The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar…
- Trial name
- NCT06422559
- Testing
- Transmagnetic stimulation, TMS
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Depression, Unipolar
Whole-body Hyperthermia for Moderate to Severe Depressive Disorder
The primary aim of this study is to investigate the effectiveness of whole-body hyperthermia in addition to standard medical care in comparison to standard medical care alone on depressive symptom severity in patients with…
- Trial name
- HYPE2 (NCT03906149)
- Testing
- Whole-body hyperthermia + standard medical care, Standard medical care
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universität Duisburg-Essen
Unipolar Depression
Transcranial Direct Current Stimulation for Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
- Trial name
- NCT07042217
- Testing
- transcranial direct current stimulation (tDCS) and mindfulness instruction
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Resistant Depression, Moods Disorders
tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients
The aim is to investigate the effect of transcranial Direct Current Stimulation (tDCS) applied at the anodal left CDLPF of patients with resistant depression compared to patients treated with conventional therapy.
- Conditions
- Resistant Depression, Moods Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- STICODEP (NCT01644747)
- Testing
- transcranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator)
- Where
- 6 sites in France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Depression, Bipolar Disorder
Telemedicine for Women With Anhedonia in Bipolar and Unipolar Disorder
Anhedonia, characterized as (a) the diminished motivation to participate in activities, and/or (b) diminished enjoyment of a pleasurable activity are common symptoms among women diagnosed with mood disorders.
- Conditions
- Depression, Bipolar Disorder, Anhedonia
- Trial name
- NCT02494050
- Testing
- Behavioral Activation-Full, Behavioral Activation-Short, Bipolar Disorder Collaborative Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Unipolar Depression, Dysthymia
A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
The investigators are adapting Interpersonal Psychotherapy (IPT-A) for adolescents who are referred to emergency services either for a suicide attempt or for being evaluated as high risk for suicidal behavior.
- Trial name
- IPT-A-CSP (NCT01447602)
- Testing
- IPT-A
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Episode (MDE), Unipolar Disorder
Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial
A significant proportion of patients remain resistant to antidepressant therapies, even when treatment is well managed. Electroconvulsive therapy (ECT) is a well-established method for treating certain severe and resistant…
- Conditions
- Major Depressive Episode (MDE), Unipolar Disorder, Bipolar 1 Disorder
- Trial name
- FEAST-AFT (NCT07857122)
- Testing
- Stimulation by the Sigma ECT/FEAST device, Stimulation by Sigmastim ECT 200J device administered in right unilateral (RUL), Stimulation by Sigmastim ECT 200J device administered in bilateral (BT)
- Where
- 5 sites in France, Monaco
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier St Anne
Major Depressive Disorder
Integral Assessment in Unipolar Depression
The objective of this project is to assess the occurrence of early improvement within the first two weeks of antidepressant treatment and to correlate this improvement with favorable therapeutic outcome at the end of the acute…
- Trial name
- AIUNI (NCT02268487)
- Testing
- Sertraline
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Depression, Unipolar Depression
Effectiveness of Light Therapy Across Seasons
This study investigates whether the antidepressant effects of bright light therapy (BLT) differ between the spring/summer season and the autumn/winter season in adults with depressive disorders.
- Conditions
- Depression, Unipolar Depression, Bipolar Depression Depressed Phase
- Trial name
- NCT07599124
- Testing
- Bright Light Therapy
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- Geestelijke Gezondheidszorg Eindhoven (GGzE)
Depressive Disorder, Depressive Disorder, Major
Brain Imaging, Genetics and Treatment for Major Depression
Background: Antidepressants help many people with depression, however, some do not seem to benefit as much. Currently, it is not possible to determine who will improve with certain antidepressants.
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depression
- Trial name
- NCT01568684
- Testing
- Citalopram
- Sponsor
- National Institute of Mental Health (NIMH)
Dislocation, Hip
Dual Mobility Cup Versus Unipolar Cup
The general purpose of this study is to examine whether the dual mobility cup (Novae® Serf) reduces the number of hip dislocations after total hip replacement, both early dislocation (≤1 year) and late dislocation (>1 year) after…
- Trial name
- NCT04685239
- Testing
- dual mobility cup, unipolar cup
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Depressive Disorder, Depression, Unipolar
Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression
This study aims to evaluate the acute and subacute effects of an inhaled N, N-Dimethyltryptamine (DMT) in patients with partial response in depression.
- Trial name
- NCT06094907
- Testing
- N,N-Dimethyltryptamine
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Anxiety State
Music Listening to Lower Anxiety During ECT Treatment.
The purpose of this study is to assess whether music listening is helpful in lowering anxiety in patients about to start their ECT treatment.
- Trial name
- MIECT (NCT04706728)
- Testing
- Listening to playlists with music prior to-, during and after the ECT procedure, Listening to playlists with sound from nature (rain, waves) prior to-, during and after the ECT procedure
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Aalborg University
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Unipolar Depression
Lamotrigine Augmentation in Resistant Depression
This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both prior non-response and prospective failure…
- Trial name
- NCT00901407
- Testing
- lamotrigine, paroxetine
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans