Clinical trials: Unipolar Disorder
Depression, Unipolar
Whole-body Hyperthermia for Moderate to Severe Depressive Disorder
The primary aim of this study is to investigate the effectiveness of whole-body hyperthermia in addition to standard medical care in comparison to standard medical care alone on depressive symptom severity in patients with…
- Trial name
- HYPE2 (NCT03906149)
- Testing
- Whole-body hyperthermia + standard medical care, Standard medical care
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universität Duisburg-Essen
Depression, Unipolar, Depression, Bipolar
BioClock: Bright Light Therapy for Depressive Disorders
Bright Light Therapy (BLT) is a proven treatment for depression in seasonal and non-seasonal depressive disorders, as well as bipolar disorder.
- Trial name
- NCT05958940
- Testing
- Bright Light Therapy, Blue Light Blocking Glasses
- Where
- 2 sites in Netherlands
- Volunteers
- 231 people
- Sponsor
- Universiteit Leiden
Unipolar Depression, Major Depressive Disorder (MDD)
Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression
The aim of this study is to validate the EmoDTx as a digital tool for mood monitoring in adult patients with unipolar depression. The study is prospective, multicenter, and observational, with a single-arm approach.
- Conditions
- Unipolar Depression, Major Depressive Disorder (MDD), Depression
- Trial name
- EMC2FR (NCT06860165)
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Emobot
Unipolar Major Depressive Disorder
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do not respond to either.
- Trial name
- NCT01875419
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Depression
Electrical Stimulation in Patients With Unipolar Major Depression
Double Blinded Randomized Trial of sTNS as adjuvant treatment for Major Unipolar Depressive Disorder. The primary objective is to assess the safety and tolerability of an implantable sTNS of the V1 branch of the trigeminal nerve…
- Trial name
- TREND1 (NCT02239809)
- Testing
- Stimulation of the trigeminal nerve (active stimulation)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital do Coracao
Major Depressive Disorder, Unipolar Depression
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; an estimated 20-40% of patients do not benefit sufficiently from existing antidepressant interventions…
- Conditions
- Major Depressive Disorder, Unipolar Depression, Depression
- Trial name
- DepressionDC (NCT02530164)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Unipolar Depression, Bipolar Depression
Berlin Magnetic Seizure Therapy Depression Trial 01
This treatment pilot study will investigate clinical efficacy and adverse effects of magnetic seizure therapy (MST) in patients currently experiencing a unipolar or bipolar depressive episode.
- Trial name
- NCT00914680
- Testing
- magnetic seizure therapy
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Charite University, Berlin, Germany
Bipolar Disorder, Cognitive Impairment
Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders
The present trial consists of 2 sub-studies that investigate important novel aspects of treatment with erythropoietin (EPO) on cognitive dysfunction in bipolar disorder (BD) and recurrent unipolar depressive disorder (UD)…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Unipolar Depression
- Trial name
- PreTEC-EPO (NCT03315897)
- Testing
- Erythropoietin, Saline
- Where
- Denmark
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Lars Vedel Kessing
Depression, Unipolar, Depressive Disorder
Gaze Contingent Feedback in Major Depressive Disorder (MDD)
The purpose of this study is to determine whether giving gaze-contingent feedback is an effective attention modification procedure, helping in the treatment of Major Depressive Disorder (MDD)
- Conditions
- Depression, Unipolar, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT02945735
- Testing
- Attention Modification
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Total Hip Arthroplasty, Osteoarthritis, Hip
Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.
Objective: The primary objective is to investigate whether there is a difference in the number of hip dislocations following primary total hip arthroplasty (THA), using the posterolateral approach, with a DM cup compared to a…
- Trial name
- REDEP (NCT04031820)
- Testing
- Unipolar cup, Dual mobility cup
- Where
- Netherlands
- Volunteers
- 1,100 people
- Sponsor
- JointResearch
Major Depressive Episode, Unipolar Depression
Ketamine As an Adjunctive Therapy for Major Depression (2)
Pragmatic, randomised, controlled, parallel-group, superiority trial of ketamine vs. midazolam as an adjunctive therapy for depression.
- Conditions
- Major Depressive Episode, Unipolar Depression, Bipolar Depression
- Trial name
- KARMA-Dep2 (NCT04939649)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 63 people
- Sponsor
- University of Dublin, Trinity College
Major Depression
Antidepressant Effects of NR2B in Major Depression
Purpose : This study will determine whether MK-0657, a selective NR2B Antagonist, can quickly improve symptoms of depressed mood, psychomotor retardation, poor motivation and reduced enjoyment of things in patients with major…
- Trial name
- NCT00472576
- Testing
- MK-0657
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Atrial Fibrillation
Efficacy Rate of Unipolar Polarity Switch for Lesion Assessment in Pulmonary Vein Isolation
The technique of intraprocedural electrogram morphology as a measure of lesion effectiveness in an attempt to achieve durable PVI, clearly led to shortened procedural time, radiation exposure, and superiority in outcomes, with…
- Trial name
- NCT05464537
- Testing
- Unipolar Polarity Switch Left, Unipolar Polarity Switch Right
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Atrial Fibrillation Paroxysmal
Outcomes of High Power Application in Catheter Ablation of Paroxysmal Atrial Fibrillation Guided by Unipolar Signal Modification.
Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation procedures in patients with paroxysmal atrial fibrillation (PAF) [1].
- Trial name
- NCT04447300
- Testing
- high power application, Standard power application
- Volunteers
- 50 people
- Sponsor
- Assiut University
Major Depression, Bipolar I Disorder
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and Drug Administration (FDA) but the investigators will use it for a…
- Conditions
- Major Depression, Bipolar I Disorder, Bipolar II Disorder, Unipolar Depression
- Trial name
- Bio-K (NCT03156504)
- Testing
- Ketamine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder, Unipolar Depression
Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study
First-line treatments for major depressive disorder (MDD), antidepressants and psychotherapy, are associated with refractoriness and discontinuation due to side effects, and logistical burdens, respectively.
- Trial name
- PSYLECT (NCT04889976)
- Testing
- Double Active: Active portable transcranial stimulation (ptES) and active internet-based behavioral therapy (iBT)
- Where
- 2 sites in Brazil
- Volunteers
- 210 people
- Sponsor
- University of Sao Paulo
Major Depression, Generalized Anxiety Disorder
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines
The hypothesis of this study is that symptoms of anxiety, depression and insomnia; and indices of psychosocial function will all improve, while BZ use will decrease significantly during a twelve-week trial period of substituting…
- Trial name
- NCT01244711
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Depression, Bipolar Depression
Efficacy of Convulsive Therapies During Continuation
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) and two different forms of electroconvulsive therapy (ECT) in sustaining response during and after a course of continuation treatment.
- Conditions
- Depression, Bipolar Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CORRECT-C (NCT03711019)
- Testing
- Magnetic Seizure Therapy (MST), RUL-UB ECT, Bitemporal ECT
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Unipolar
Treating Major Depression With Yoga: A Prospective, Randomized Controlled Pilot Trial
This was a randomized controlled pilot trial to evaluate clinical efficacy and feasibility of hatha yoga as a mono-therapy for major depression.
- Trial name
- NCT01210651
- Testing
- Hatha Yoga Practice Group, Attention Control Education Group
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Unipolar Depression
Amitriptyline and Paroxetine Treatment of Major Depression
Activation of the hypothalamus-pituitary-adrenal system is monitored using saliva cortisol sampling during the antidepressant treatment with amitriptyline and paroxetine in moderately to severely depressed patients.
- Trial name
- NCT01049347
- Testing
- amitriptyline, paroxetine
- Where
- Germany
- Volunteers
- 127 people
- Sponsor
- Central Institute of Mental Health, Mannheim