Clinical trials: Unsedated
Esophagogastroduodensocopy (EGD) Procedure
Ondansetron Combined with Dyclonine Hydrochloride to Improve Patient Experience in Unsedated Esophagogastro-duodenoscopy
The goal of this clinical trial is to learn if administering ondansetron prior to esophagogastroduodenoscopy (EGD) can alleviate the gagging reflex, nausea and vomiting in Chinese patients undergoing unsedated diagnostic EGD.
- Trial name
- NCT06729307
- Testing
- Oral ondansetron and dyclonine hydrochloride mucilage, Dyclonine hydrochloride mucilage
- Volunteers
- 260 people
- Sponsor
- Peking Union Medical College Hospital
Risk Factors Associated With Painful Colonoscopy
Discomfort Score Identifies Painfulness During Unsedated Colonoscopy
Some patients felt no pain or only mild discomfort with the unsedated colonoscopy. However, unsedated colonoscopy was thought to be an option for some but not for all.
- Trial name
- NCT03540173
- Where
- 2 sites in China
- Volunteers
- 1,220 people
- Sponsor
- Air Force Military Medical University, China
Esophagogastroduodensocopy (EGD) Procedure
Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study
The goal of this interventional pilot study is to explore the feasibility of administering ondansetron prior to esophagogastroduodenoscopy (EGD), and preliminarily test if it can alleviate the gagging reflex, nausea and vomiting…
- Trial name
- NCT07264738
- Testing
- ondansetron and dyclonine hydrochloride, dyclonine hydrochloride only
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Effect of Endoscope Water Pump Flow Rates
The Effect of Endoscope Water Pump Flow Rates on Successful Unsedated Colonoscopy by Water Immersion Method: a Randomized Controlled Trial
The purpose of this study is to compare the cecal intubation rate between two endoscopy water pump with different flow rates (1.7 ml/sec vs 10.4 ml/sec) in water immersion colonoscopy examination in unsedated patients undergoing…
- Trial name
- NCT01869296
- Testing
- higher flow rates, lower flow rates
- Where
- Indonesia
- Volunteers
- 132 people
- Sponsor
- Gadjah Mada University
Anxiety, Pain
Verbal Suggestion to Reduce Pain and Anxiety During Unsedated Colonoscopy
Colonoscopy is an important diagnostic and screening procedure for colorectal diseases, but it can cause pain and anxiety, especially when performed without sedation.
- Conditions
- Anxiety, Pain, Colonoscopy, Patient Comfort
- Trial name
- NCT07228884
- Testing
- Verbal Suggestion
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colonoscopy
The Clinical Acceptability of Unsedated Colonoscopy
The study was aimed to prospectively evaluate the acceptance rate of unsedated colonoscopy, in a setting where routine sedation for colonoscopy is standard practice and to characterize the subset of patients willing to try and…
- Trial name
- NCT01434927
- Testing
- Unsedated colonoscopy
- Where
- Italy
- Volunteers
- 964 people
- Sponsor
- Valduce Hospital
Colorectal Cancer, Colorectal Adenomas
Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening
The degree of protection afforded by colonoscopy against proximal colorectal cancer (CRC) appears to be related to the quality of the procedure, and the incomplete removal of lesions has been shown to increase the subsequent risk…
- Conditions
- Colorectal Cancer, Colorectal Adenomas, Colorectal Polyps, Pain
- Trial name
- NCT02041507
- Testing
- Air insufflation method., Water Immersion method., Water Exchange method.
- Where
- 4 sites in United States, Czechia and 1 more
- Volunteers
- 1,224 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Uterus Dysfunction
Pain Relief During Unsedated Office Hysteroscopy by Applying TENS
Aim: To compare the pain-relieving effect of a specific application of TENS vs. placebo TENS and a control group during unsedated diagnostic office hysteroscopy. Design: double-blind randomized placebo-controlled trial.
- Trial name
- NCT02647008
- Testing
- TENS
- Where
- Spain
- Volunteers
- 138 people
- Sponsor
- Cardenal Herrera University
Colon Polyp
Unsedated Colonoscopy for Colorectal Cancer Screening and Surveillance
In a prospective, randomized, controlled study, two methods (water method vs. air method) of performing colonoscopy will be compared in patients undergoing unsedated colonoscopy for CRC screening.
- Trial name
- NCT01383252
- Testing
- Water infusion in lieu of air insufflation, Air method
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Northern California Health Care System
Gastrointestinal Symptoms
Dyclonine vs. Tetracaine for Local Anesthesia in Unsedated Gastroscopy
Gastroscopy is a key diagnostic approach for upper gastrointestinal diseases, but pharyngeal passage of the gastroscopy often causes participants' discomfort.
- Trial name
- NCT07691346
- Testing
- Dyclonine hydrochloride mucilage, Tetracaine Hydrochloride Jelly
- Where
- China
- Volunteers
- 208 people
- Sponsor
- General Hospital of Shenyang Military Region
Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding
Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients
This prospective observational cohort study aims to compare the safety and clinical outcomes of sedated and unsedated percutaneous endoscopic gastrostomy procedures in elderly patients classified as ASA IV.
- Conditions
- Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding, Dysphagia, Elderly Patients (>65 Years)
- Trial name
- NCT07758153
- Volunteers
- 70 people
- Sponsor
- Mersin University
Polyp, Pain
Left-colon WEC May Reduce Insertion Time Compared With Whole-colon WEC.
In most of situation, left colon (especially SD junction) is considered the most difficult part of colonoscopy, where endoscopist may encounter difficulty for scope insertion and patients may feel pain or uncomfortable.
- Trial name
- NCT01735266
- Testing
- Air colonoscopy, Water exchange colonoscopy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Air Force Military Medical University, China
Healthy
Feasibility, Safety and Utility of Endomicroscopy to Study the Intestines of Unsedated Infants at UVa
The purpose of this study is to demonstrate the feasibility of using the transnasal endomicroscopy (TNE) platform, using intestinal potential difference (IPD) and microbiome brush to evaluate the intestine of unsedated infants.
- Trial name
- NCT05857488
- Testing
- Transnasal introduction tube
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Unsedated Colonoscopy, Water Exchange Colonoscopy
Prospective RCT Of Water Exchange (WE) vs. WE Plus Cap-Assisted Colonoscopy
This is a study to compare two different, but normally, used methods of colonoscopy in patients undergoing colonoscopy without sedation.
- Conditions
- Unsedated Colonoscopy, Water Exchange Colonoscopy, Cap, Colonoscopy Pain
- Trial name
- NCT03160859
- Testing
- Control, Study method
- Where
- 3 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Water Exchange Colonoscopy
Minimal Water Exchange Versus Left Water Exchange in Unsedated Colonoscopy
Minimal water exchange colonoscopy is theoretically more convenient and faster than water exchange colonoscopy. But few studies compared the differences between the two methods.
- Trial name
- NCT04952142
- Testing
- minimal water exchange
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Patient Satisfaction
Consented Unsedated Endoscopy in High Risk Patients That Require Anesthesiologist Observation During the Procedure
This study aim to examine the safety and feasibility of unsedated colonoscopy in patients with high risk for sedation (ASA score≥3).
- Trial name
- NCT05842720
- Testing
- un-sedated colonoscopies
- Where
- Israel
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pain, Colorectal Adenomas
A Comparison of Air Insufflation, Water Immersion and Water Exchange Colonoscopy in Diagnostic Patients
Water-aided method for colonoscopy can be broadly subdivided into two major categories. Water Immersion (WI), characterized by suction removal of the infused water predominantly during the withdrawal phase of colonoscopy, and…
- Conditions
- Pain, Colorectal Adenomas, Colorectal Cancer
- Trial name
- NCT01781650
- Testing
- Air Insufflation method., Water Immersion method., Water Exchange method.
- Where
- 3 sites in United States, Italy
- Volunteers
- 288 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Colonoscopy Diagnostic Techniques and Procedures
The Water Method Colonoscopy in Routine Unsedated Colonoscopy Examinations
Aim of the Study : This study will compare the colonoscopy examination between the air method (air insufflation) and water method (water infusion) in unsedated patients with indication (symptoms and signs based) of colonoscopy…
- Trial name
- NCT01341847
- Testing
- water method colonoscopy, air method colonoscopy
- Where
- Indonesia
- Volunteers
- 110 people
- Sponsor
- Gadjah Mada University
Colonoscopy
Can Simple and Inexpensive Techniques Enhance Patient Comfort
This research study compares two methods of performing colonoscopy without sedation. The standard method is to insert the colonoscope without adding any water to the colon, and when colonic spasms occur during the examination…
- Trial name
- NCT00747084
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Eosinophilic Esophagitis
CEGIR 7808: Use of Unsedated Transnasal Esophagoscopy (TNE) to Monitor Dietary Management of Eosinophilic Esophagitis in Children
The purpose of this study is to test the effectiveness of utilizing Transnasal Esophagoscopy as a means of monitoring Eosinophilic Esophagitis patients.
- Trial name
- NCT03342391
- Testing
- Transnasal esophagoscopy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati