Clinical trials: Upper Extremity Impairments, open to volunteers
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Tetraplegia, Spinal Cord Injury
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
- Conditions
- Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury
- Trial name
- CRS-BMI (NCT01894802)
- Testing
- Implantation of CRS Arrays
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Michael Boninger
Disability Physical
Evaluation of ORTHOPUS Partner Arm in People With Disabilities Needing for Robotic Assistance to Compensate for Upper Limb Deficiency
The study is a prospective, multicenter, interventional, open clinical trial, in Single Case Experimental Design (SCED) in multiple introduction withdrawal, controlled, randomized.
- Trial name
- MS PARTNER (NCT06828510)
- Testing
- With device
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)
Although the Blood Flow Restriction Training (BFRT) system has attracted the attention of health professionals, research on this tool in people with neurological pathology, particularly multiple sclerosis (MS), is very limited.
- Trial name
- BFRT-EM (NCT06795230)
- Testing
- Muscle strengthening (BFRT), Conventional physical therapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Rey Juan Carlos
Stroke, Hemiparesis
Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery
This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke.
- Conditions
- Stroke, Hemiparesis, Upper Extremity Impairments, Stroke Rehabilitation
- Trial name
- NCT07661849
- Testing
- Tele-CPASS, In-person CPASS therapy
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Texas, El Paso
User of an Upper Limb Assistance Device, User Experience
Impact Study on Users of Upper Limb Assistive Devices
This impact study of upper limb (UL) assistance devices is part of the Exploratory PEPR O2R "Robotic assistance for human movements." The integrated project PI3 "ASSISTMOV," composed of a multidisciplinary team in engineering and…
- Conditions
- User of an Upper Limb Assistance Device, User Experience, Post-stroke, Spinal Cord Injury
- Trial name
- AMUSE (NCT07429188)
- Testing
- interviews and questionnaires
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Association APPROCHE
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Hearing Loss, Cognitive Impairment
Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment
Hearing loss and cognitive impairment are common and interrelated health problems that may affect communication, information processing, attention, psychological well-being, daily functioning, and quality of life.
- Trial name
- A-COP (NCT07869745)
- Testing
- Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Taipei Medical University
Hemiplegia, Spasticity
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add…
- Conditions
- Hemiplegia, Spasticity, Shoulder Spasticity, Shoulder Stiffness
- Trial name
- spastiCRYO-UL (NCT06782464)
- Testing
- Treatment
- Where
- Luxembourg
- Volunteers
- 50 people
- Sponsor
- Centre National de Rééducation Fonctionnelle et de Réadaptation
Stroke, Upper Limb Paresis
Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)
The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment.
- Trial name
- MAP2024SJD (NCT07787793)
- Testing
- High-frequency repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Ancor Rebassa Cabrera
Stroke, Upper-limb Motor Impairment
Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments
This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or…
- Conditions
- Stroke, Upper-limb Motor Impairment, Hemiparesis, Spinal Cord Injury
- Trial name
- NCT07404761
- Testing
- Spatial StimelMD (SSMD), Functional Electrical Stimulation (FES)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Motion Informatics LTD
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Ischemic Stroke, Upper Limb Motor Impairment
Neurophysiological Markers for Prediction of Rehabilitation Outcomes After Ischemic Stroke
The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke.
- Trial name
- NCT07520630
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Stroke, Arm Weakness as a Consequence of Stroke
Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization
The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a…
- Conditions
- Stroke, Arm Weakness as a Consequence of Stroke, Upper Extremity Hemiparesis, Upper Extremity Impairments
- Trial name
- LIFUS-OPTIMIZE (NCT07220005)
- Testing
- Low intensity focused ultrasound stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Stroke
Unilateral Versus Bilateral Task-specific Training on Motor Impairment, Upper Extremity Function, and Hand Dexterity in Post-Stroke Rehabilitation
This randomized clinical trial will examine upper limb rehabilitation in individuals recovering from stroke. The study will compare unilateral and bilateral task-oriented training approaches to determine their relative…
- Trial name
- NCT07523503
- Testing
- Unilateral task oriented training (UTOT) with baseline EMS, Bilateral task oriented training (BTOT) with baseline EMS
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Faisalabad
Cervical Radiculopathy, Cervical Radicular Pain
Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Proprioception in Patients With Chronic Cervical Radiculopathy
Cervical radiculopathy is a common condition caused by irritation or compression of cervical nerve roots, often leading to unilateral neuropathic pain and functional impairment.
- Conditions
- Cervical Radiculopathy, Cervical Radicular Pain, Proprioception
- Trial name
- NCT07307846
- Testing
- Interlaminar Epidural Steroid Injection (ILESI)
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Marmara University
Shoulder Posterior Instability, Shoulder Anterior Instability
Evaluating Upper Limb Movement Precision With AuReha in People With One-Sided Motor Impairment
The clinical investigation is designed as a controlled, two-arm, intra-patient, non-randomized interventional study aimed at assessing the capabilities of the AuReha system in detecting upper limb movement precision in patients…
- Conditions
- Shoulder Posterior Instability, Shoulder Anterior Instability, Shoulder Anterior Latarjet Instability, Adhesive Capsulitis, Shoulder
- Trial name
- NCT07133100
- Testing
- Upper limb rehabilitation wearable device
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- DigitalRehab
Post Traumatic Stress Disorder
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms…
- Trial name
- NCT05790239
- Testing
- 3,4-methylenedioxymethamphetamine, d-amphetamine, Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Stephen Robert Marder
Chronic Stroke Patient, Motor Impairment
Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)
Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event.
- Conditions
- Chronic Stroke Patient, Motor Impairment, Neurorehabilitation, Theta Burst Stimulation
- Trial name
- INSPIRE (NCT07439367)
- Testing
- Active iTBS, Tablet-based upper limb training
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University