Clinical trials: Upper Gastrointestinal Disorders
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Upper Gastrointestinal Bleeding (UGIB), Emergency Department Patient
A New Risk Score for the Emergency Department in Patients With Upper Gastrointestinal Bleeding
Abstract Background: The aim of this study was to develop a simpler, more practical, and highly effective risk scoring system for patients presenting to the emergency department with upper gastrointestinal bleeding.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Emergency Department Patient, Risk Scores
- Trial name
- NCT06878183
- Testing
- Routine laboratory tests of the patients were examined (such as hemogram, biochemistry, bleeding parameters).
- Where
- Turkey (Türkiye)
- Volunteers
- 589 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Nonvariceal Upper Gastrointestinal Bleeding
Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding
Introduction: Proton pump inhibitor (PPI) is the drug of choice used in patients with non-variceal upper gastrointestinal tract bleeding (UGIB).
- Trial name
- NCT00861640
- Testing
- Intravenous Omeprazole, Oral Rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Irritable Bowel Syndrome With Diarrhea
Effects of the Multispecies Probiotic Ecologic Barrier in IBS Patients With Upper GI Symptoms and Anxiety, Depression, or Stress
The aim of this clinical trial is to find out whether Ecologic Barrier is effective in supporting the treatment of irritable bowel syndrome (IBS) in adults.
- Trial name
- NCT07656623
- Testing
- Ecologic Barrier
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Institute of Gastroenterology and Hepatology, Vietnam
Liver Diseases
Effect of Non-alcoholic Fatty Liver Disease on Kidney Functions
Non-alcoholic fatty liver disease is the most common cause of chronic liver disease worldwide. It is defined as the accumulation of fat (>5%) in the liver cells in the absence of excessive alcohol intake or other causes of liver…
- Trial name
- NCT03172650
- Testing
- glomerular filtration rate
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors
EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELs
Sub epithelial lesions (SELs) of the gastrointestinal (GI) tract are commonly identified during routine endoscopy. Most of these lesions are benign.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms
- Trial name
- NCT02866045
- Testing
- EUS-guided fine needle biopsy, Single incision needle knife biopsy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Thrombosis, Deep Venous Thrombosis
Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer
Cancer is a well known risk factor for venous thromboembolism (VTE) such as deep venous thrombosis (DVT) and pulmonary embolism (PE).
- Conditions
- Thrombosis, Deep Venous Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- GIVTE (NCT00660205)
- Where
- Denmark
- Volunteers
- 285 people
- Sponsor
- University of Aarhus
Gastrointestinal Neoplasms, Ovarian Neoplasms
Low Dose Upper Abdominal Radiation Therapy (LD-UART) + Gemcitabine in Patients With Advanced, Unresectable Pancreatic Cancer (PC)
The purposes of this study are: 1. To assess the maximum tolerated dose of low-dose UART(Upper Abdominal Radiation Therapy ) or WART(Whole Abdominal Radiation Therapy) given in combination with standard fixed dose-rate…
- Trial name
- GCC0319 (NCT00390182)
- Testing
- Gemcitabine
- Where
- 2 sites in United States, Canada
- Volunteers
- 38 people
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes
Intraluminal Imaging of Duodenal Layer Morphometry in Patients With and Without Type 2 Diabetes
This observational study is conducted to determine how the duodenal layer thicknesses (mucosa, submucosa, and muscularis) vary with several factors in patients with and without type 2 diabetes.
- Trial name
- NCT02688920
- Testing
- EUS and OCT imaging
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Victoria Gomez
Airway Edema, Perioperative Complication
Ultrasound Assessment of Airway Edema During Laparoscopic Cholecystectomy
This prospective, double-blind, randomized clinical trial aims to investigate the development of airway edema associated with intra-abdominal pressure during laparoscopic cholecystectomy.
- Conditions
- Airway Edema, Perioperative Complication, Pneumoperitoneum
- Trial name
- NCT07021482
- Testing
- 10 mmHg Pneumoperitoneum, 14 mmHg Pneumoperitoneum
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Engin Çetin
Barrett's Esophagus
"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
Neoplasia in Barrett's esophagus could be missed during routine random biopsies. We propose a study using chromoendoscopy with Acetic Acid to increase the yield of biopsies in detecting neoplasia.
- Trial name
- NCT02614703
- Testing
- Chromoendoscopy using Acetic Acid 2.5%, Standard random esophageal biopsies
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- DHR Health Institute for Research and Development
Cystic Fibrosis, Primary Ciliary Dyskinesia
Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia
Cytobacteriological examination of sputum and bacteriological sampling in the middle meatus.
- Trial name
- BAVASI (NCT03494894)
- Testing
- Middle meatus aspirations and sputum
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Bleeding Peptic Ulcer, Active Bleeding
Urgent vs. Early Endoscopy in High Risk Patients With Upper Gastrointestinal Bleeding (UGIB)
Acute upper gastrointestinal bleeding (UGIB) is one of the commonest medical emergencies. The condition accounts for 150 per 100,000 populations. A National United Kingdom reported a crude overall mortality rate of 10%.
- Conditions
- Bleeding Peptic Ulcer, Active Bleeding, Gastrointestinal Bleeding
- Trial name
- NCT01675856
- Testing
- Urgent endoscopy, Early endoscopy
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Varices, Portal Hypertension
Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings
The goal of this observational study: To evaluate the diagnostic accuracy of non-invasive markers in predicting the presence and grading of esophageal varices in children with portal hypertension.
- Trial name
- NCT07464522
- Volunteers
- 51 people
- Sponsor
- Assiut University
Upper Gastrointestinal Submucosal Tumors (SMTs), Gastrointestinal Stromal Tumors (GISTs)
ESTD vs. VATS for Upper Gastrointestinal Submucosal Tumors
The purpose of this study is to determine the efficacy and safety of endoscopic submucosal tunnel dissection (ESTD) compared with video-assisted thoracoscopic surgery (VATS) in the treatment of upper gastrointestinal submucosal…
- Conditions
- Upper Gastrointestinal Submucosal Tumors (SMTs), Gastrointestinal Stromal Tumors (GISTs), Leiomyoma
- Trial name
- NCT01768104
- Testing
- ESTD, VATS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Dysphagia, Respiratory Complications
Trial- Dysphagia From ETT or GI Endoscopy
The purpose of this study is to conduct a randomized clinical trial to compare the incidence of dysphagia in patients receiving general anesthesia with and without an endotracheal tube for Upper gastrointestinal endoscopy.
- Trial name
- NCT02460055
- Testing
- endotracheal tube, propofol, Fentanyl
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
GERD (Gastroesophageal Reflux Disease)
Upper GI MM vs Manometry
Research will consist of retrospective review of prospective cohort quantitative data collection with the goal of comparing preoperative High-Resolution Manometry (HRM) results to Upper Gastrointestinal Marshmallow (UGIMM)…
- Trial name
- NCT06973070
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Lexington Health Incorporated
Gastroscopy; Gastric Cancer
Mucolytic Solution Before Upper Endoscopy
Study was designed to evaluate efficacy of mucolytic solution ingested before upper endoscopy on visibility of gastric mucosa.
- Trial name
- NCT02967094
- Testing
- Administration of mucolytic solution before upper endoscopy (Espumisan, ACC long), Administration of water before upper endoscopy
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Vitkovice Hospital
Leakage After Esophagectomy, Leakage After Gastrectomy
Eso-Sponge Registry
This international, prospective and multicenter registry was designed to collect clinical evidence for the endoscopic vacuum treatment using Eso-SPONGE® for anastomotic leakage after esophageal resection or iatrogenic or…
- Conditions
- Leakage After Esophagectomy, Leakage After Gastrectomy, Perforation of the Esophagus
- Trial name
- NCT02662777
- Testing
- Eso-SPONGE® vacuum treatment
- Where
- 17 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Aesculap AG
Metastatic Colorectal Cancer
Envafolimab Combined With Trifluridine/Tipiracil and Bevacizumab in the Treatment of Refractory mCRC.
The goal of this single-arm study is to evaluate the efficacy and safety of Envafolimab combined with Trifluridine/Tipiracil and Bevacizumab in the treatment of metastatic colorectal cancer patients who are refractory or…
- Trial name
- NCT06060704
- Testing
- Envafolimab, Trifluridine/Tipiracil, Bevacizumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University