Clinical trials: Upper Gastrointestinal Disorders
Neuroendocrine Carcinoma
P:II Above-Label Octreotide-LAR With Insufficiently Controlled Carcinoid Syndrome
The primary purpose of the study is to investigate the effects of high-dose octreotide on flushing, diarrhea, and quality of life in patients whose disease-related symptoms are inadequately controlled by the maximum approved dose…
- Trial name
- NCT01886287
- Testing
- Octreotide LAR
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastrointestinal Fistula, Enteral Nutritional Support
Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery
The incidence of clinically significant anastomotic leaks (AL) after upper gastrointestinal (GI) surgery is approximately 4 % - 20 %, and the associated mortality can be as high as 80 % .
- Trial name
- NUTRILEAK (NCT03742752)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
CYSTIC FIBROSIS
Effect of Lactobacillus Reuteri in Cystic Fibrosis
The purpose of this study is to evaluate in patients with cystic fibrosis the effect of Lactobacillus Reuteri (LR) on the rate of respiratory exacerbations and of the infections of both upper respiratory and gastrointestinal…
- Trial name
- NCT01737983
- Testing
- Lactobacillus reuteri
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Azienda Policlinico Umberto I
Gastroesophageal Reflux
MSG and Gastrointestinal Motility
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Trial name
- NCT01009658
- Testing
- Monosodium glutamate, Sodium chloride
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gunma University
Cystic Fibrosis (CF)
Sweat Testing in Infants: Comparing Sweat Collection on Upper Vs Lower Limbs
The goal of this study is to compare the rate of Quantity Not Sufficient (QNS) during sweat collection in infants under 6 months of age, using the Macroduct Advanced device for sweat testing.
- Trial name
- NCT06902363
- Testing
- Macroduct Advanced
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Gastroesophageal Reflux, Esophageal Motility Disorders
High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux
This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative…
- Conditions
- Gastroesophageal Reflux, Esophageal Motility Disorders, Upper Gastrointestinal Disorder
- Trial name
- NCT05132816
- Testing
- high-resolution manometry
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Superior Mesenteric Artery Syndrome, Duodenal Obstruction
Comparison of One Anastomisis Gastric Bypass and Duodeno-Jejunostomy for Treating SMA Syndrome
The goal of this clinical trial is to find out which surgery works better to treat people with a rare condition called Superior Mesenteric Artery Syndrome (SMAS).
- Conditions
- Superior Mesenteric Artery Syndrome, Duodenal Obstruction, Weight Loss, Gastrointestinal Disease
- Trial name
- NCT06970093
- Testing
- One Anastomosis Gastric Bypass, Duodenojejunostomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Cystic Fibrosis, Pseudomonas Aeruginosa
Sino-nasal Inhalation of Colistin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization
The purpose of this study is to determine whether the nasal inhalation of Colistin is effective to decrease the Pseudomonas aeruginosa bacterial count in the nasal lavage fluid.
- Trial name
- NCT01035853
- Testing
- Colistin
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Jena
Upper Gastrointestinal Subepithelial Tumors
Biopsy Protocol of Upper Gastrointestinal Subepithelial Tumors:Diagnostic Accuracy of EUS-FNB Versus Unroofing Biopsy
To increase the diagnostic accuracy of subepithelial tumors, larger tissue samples are required. It is difficult to obtain adequate tissue samples. There were several biopsy methods to obtain tissue samples.
- Trial name
- NCT02646241
- Testing
- unroofing biopsy, EUS-FNB(endoscopic ultrasonography guided fine needle biopsy)
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Upper GI Bleeding
Presence or Absence of Blood in the GI Lumen
Bleedings in the upper digestive tract are common. Usually, laboratory and clinical parameters are considered to establish a suspicion for a bleeding in the digestive tract and to estimate urgency of the situation.
- Trial name
- NCT05415124
- Testing
- HemoPill, Endoscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Upper Gastrointestinal Disorders
Effect of Virtual Reality Before Upper Gastrointestinal Endoscopy on Preprocedural Anxiety, Psychological Readiness, and Postprocedural Satisfaction
Objective: This study aims to evaluate the effect of virtual reality applied before upper gastrointestinal endoscopy on preprocedural anxiety, psychological readiness, and postprocedural satisfaction.
- Trial name
- NCT07745959
- Testing
- Virtual Reality, Standard Preprocedural Care
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ardahan University
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Gastrointestinal Bleeding
Early Endoscopy for Acute Upper Gastrointestinal Bleeding in Acute Coronary Syndrome Patients
The primary aim of this study is to compare efficacy of "early endoscopy" and "non-endoscopic treatment" for management of acute upper gastrointestinal (UGI) bleeding in patients with recent acute coronary syndrome (ACS).
- Trial name
- NCT02618980
- Testing
- endoscopic hemostasis
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Far Eastern Memorial Hospital
Oesphageal Cancer, Para-conduit Hernia
The PHARO Trial: The Incidence of Para-conduit Hernia With Closure of Hiatus Versus the Standard Approach in Robotic Oesophagectomy - A Randomised Controlled Pilot Trial
Para-conduit hernia is a recognised complication following minimally invasive and robotic oesophagectomy. It may present as an incidental radiological finding or as a symptomatic hernia requiring urgent surgical intervention.
- Trial name
- PHARO (NCT07426835)
- Testing
- Standard Hiatal Management, Hiatal Closure With Omentopexy and Left Crus Fixation
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Royal College of Surgeons, Ireland
Cancer Esophagus, Pancreatic Cancer
Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery
Every patient undergoing surgery in the abdomen will experience temporary paralysis of bowel function. This study evaluates whether chewing gum can reduce the bowel paralysis after surgery in patients undergoing either esophageal…
- Trial name
- NCT02260128
- Testing
- Chewing gum
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Michael Bau Mortensen
Pain, Neuropathic Pain
Assessments on Current Pain Managements in Upper Gastrointestinal Cancer Patients
Pain is one of the most common symptoms associated with cancer. The approach to pain management compresses routine pain assessments, utilizes both pharmacologic and nonpharmacologic interventions, and requires ongoing…
- Conditions
- Pain, Neuropathic Pain, Depression, Quality of Life
- Trial name
- NCT01718821
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng Kung University
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
Necrotizing Enterocolitis
SMA Flow Patterns in Neonatal Transfusion
This study aims to measure the changes induced by packed red blood cell (PRBC) transfusion in the superior mesenteric artery (SMA) flow velocity and intestinal oxygenation indices in premature neonates.
- Trial name
- SPARTAN (NCT02347475)
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Calgary
Volatile Organic Compound, Gastrointestinal Hemorrhage
Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath.
- Trial name
- VOCsAUGIB (NCT06877507)
- Testing
- Gastroscopy, Gas Chromatography - Mass Spectrometry
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital