Clinical trials: Upper Gastrointestinal Tumours
Esophageal Neoplasm, Head and Neck Neoplasm
The Effects of Upper Airway and Digestive Tract Tumors on the Immune System
The goal of this study is to learn how tumors of the upper airway and digestive passages (tongue, throat, mouth, and voicebox) affect the body's immune defenses and energy storage.
- Conditions
- Esophageal Neoplasm, Head and Neck Neoplasm, Laryngeal Neoplasm, Papilloma
- Trial name
- NCT00001603
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Squamous Cell Carcinoma, Breath Test
Early Diagnosis of Upper Digestive Tract Disease
Upper digestive tract cancer (UDC) is a major disease burden worldwide encompassing all cancers involving the digestive tract (from oral cavity to duodenum).
- Conditions
- Squamous Cell Carcinoma, Breath Test, Digestive System Disease, Diagnose Disease
- Trial name
- E-DIGEST (NCT04475952)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gastric Cancer (GC), Gastric Adenocarcinoma
Costs of Opportunistic Upper Gastrointestinal Endoscopy and the Economic Burden of Gastric Cancer Management
Data will be extracted from routinely collected hospital databases.
- Trial name
- EconROGCAS (NCT07522320)
- Where
- Portugal
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Esophageal Cancer, Nutrition Disorders
Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
The incidence of oesophagogastric cancer has increased by 400% since the 1970s in Ireland and the United Kingdom. In addition, refinement of perioperative management and the now widespread use of multimodal protocols for patients…
- Conditions
- Esophageal Cancer, Nutrition Disorders, Appetite Disorders, Dumping Syndrome
- Trial name
- EndoGut (NCT03734627)
- Testing
- Octreotide Acetate, Saline Solution, Paracetamol
- Where
- 2 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastric Cancer
Validating the Safety and Effectiveness of ENDOANGEL Upper Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
The upper Gastrointestinal Endoscope Image Auxiliary Diagnostic Software developed by Wuhan ENDOANGEL Medical Technology Co., Ltd.
- Trial name
- NCT05470452
- Testing
- The reading process is assisted by ENDOANGEL, No ENDOANGEL assistance during the reading process
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Healthy Individual
CDSS-assisted UGI Endoscopy vs. Routine Screening Endoscopy
This study aimed to find the CDSS-assisted upper GI endoscopy has clinical benefit compared to conventional routine screening upper GI endoscopy. Investigators will conduct a pilot randomized controlled study.
- Trial name
- NCT05452473
- Testing
- CDSS-assisted upper GI endoscopy, no intervention
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Barrett Esophagus, Gastroesophageal Reflux
Demographics and Findings of Upper Endoscopy Patients
The purpose of this study is to evaluate the demographics, patients symptoms, and findings during endoscopy. Patients presenting for an endoscopy procedure to the KCVA GI endoscopy suite, will be asked to fill out questionnaires…
- Trial name
- NCT00576992
- Where
- United States
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Advanced Cancer, Olanzapine
Survival With Olanzapine in Patients With Locally Advanced or Metastatic Upper Gastrointestinal and Lung Cancer
This study aims to assess the impact of adding olanzapine to nutritional advice and standard anti-tumor therapy on the survival and safety of patients with locally advanced, unresectable or metastatic gastric cancer, esophageal…
- Conditions
- Advanced Cancer, Olanzapine, Progression Free Survival
- Trial name
- NCT06338683
- Testing
- Olanzapine 2.5 MG, Standard anti-tumor treatment, Nutritional advice
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Qinghai Red Cross Hospital
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Gastric Cancer, Pancreatic Cancer
The Impact of Immunostimulating Nutrition on the Outcome of Surgery
The aim of the study was to assess the clinical effect of immunostimulatory enteral and parenteral nutrition in patients undergoing resection for gastrointestinal cancer.
- Trial name
- NCT00558155
- Testing
- peptisorb, Stresson, Parenteral nutrition
- Where
- Poland
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Advanced Colorectal Neoplasms, Throat Cancer
Fecal Screening Assay for Taiwanese Population
Fecal occult blood test (FOBT) is a convenient tool for the screening of asymptomatic gastrointestinal (GI) bleeding while 「guaiac-based fecal occult test (G-FOBT) 」 is increasingly replaced by the use of an 「immunochemical-based…
- Conditions
- Advanced Colorectal Neoplasms, Throat Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT01341197
- Testing
- Fecal immunochemical test, guaiac fecal occult-blood test, and Helicobacter pylori stool antigen test
- Where
- Taiwan
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cancer, Rectum
Converted Laparoscopic Resection of Upper Rectal Carcinoma T1-4 N0-1 in Obese Patients.
Background: laparoscopic resection (LAR) is a safe approach and widely used for rectal cancer after neoadjuvant chemo-radiotherapy, but short term and oncological outcome for converted cases to open surgery (cLAR), may be…
- Trial name
- NCT04401787
- Testing
- Anterior resection for upper rectal cancer in obese
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Multiple Primary Lung Cancer, Microbial Colonization
Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer
This is an exploratory, single-center, being conducted at Beijing Haidian Hospital in order to detect the relationship between microbiome of upper gastrointestinal and pathogenesis of multiple primary lung cancer.
- Trial name
- NCT06973499
- Testing
- Microbiome Profiling and Symptom Assessment
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
Gut Microbiota
Establishment of Individualized Immunotherapy Strategy and Platform Based on Changes of Intestinal Microbiota
To explore and analyze the relationship between intestinal flora changes and the efficacy of individualized immunotherapy in patients with upper gastrointestinal cancer, and to find new biomarkers to predict the efficacy of…
- Trial name
- NCT05065515
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Esophagogastroduodenoscopy, Simethicone
Premedication With N-acetylcysteine and Simethicone to Improve Mucosal Visualization in Elective Upper Endoscopy
The goal of this randomized, double-blind, placebo-controlled clinical trial is to assess whether the combination of N-acetylcysteine and simethicone improves mucosal visibility during upper gastrointestinal endoscopy in adults…
- Conditions
- Esophagogastroduodenoscopy, Simethicone, N-Acetylcysteine, Premedication
- Trial name
- NACSIMET (NCT07245095)
- Testing
- Premedication with n-acetylcysteine, Premedication with simethicone
- Where
- 2 sites in Mexico
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexicali
Urothelial Carcinoma, Lynch Syndrome
Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
Lynch syndrome (LS) is an inherited cancer predisposition syndrome caused by pathogenic germline variants in DNA mismatch repair (MMR) genes.
- Trial name
- NCT06218433
- Testing
- Urothelial cancer screening using urine tumor DNA test, Urothelial cancer screening using urine cytology (comparator)
- Where
- 2 sites in Canada, Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Gastroscopy Time, Early Gastric Cancer
Setting the Shortest Examination Time of Gastroscopy to Improve the Detection Rate of Upper Gastrointestinal Tumors
This multicenter, prospective, interventional study aims to include 2000 gastroscopic procedures and investigate the relationship between procedure time and lesion detection rate in tertiary endoscopic centers in China.
- Conditions
- Gastroscopy Time, Early Gastric Cancer, Detection Rate
- Trial name
- NCT04602299
- Testing
- Set the minimum time of gastroscopy
- Where
- 2 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Gastric Cancer, Esophagus Cancer
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy…
- Trial name
- NCT06278064
- Testing
- Gastric Cancer, Esophagus Cancer
- Where
- 3 sites in China
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital