Clinical trials: Upper Limb Dysfunction
Parkinson Disease, Virtual Reality
Upper Extremity Rehabilitation With Virtual Reality in Parkinson's Disease Patients
Upper extremities are the first part of the body to be affected by Parkinson's disease. Although studies have shown that virtual reality-assisted rehabilitation methods are effective on gait and balance, studies on their use for…
- Conditions
- Parkinson Disease, Virtual Reality, Neurological Rehabilitation, Upper Extremity Dysfunction
- Trial name
- NCT06147726
- Testing
- Upper extremity position matching exercises in virtual reality, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ramazan KURUL
Premature Ejaculation
A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation
The purpose of this study is to evaluate the safety and efficacy of on-demand therapy with CDFR0812-15/25mg and CDFR0812-15/50mg compared to on-demand therapy with single-drug administration of Clomipramine HCl 15mg in Korean…
- Trial name
- NCT02571101
- Testing
- CDFR0812-15/25mg, CDFR0812-15/50mg, Condencia
- Where
- 9 sites in South Korea
- Volunteers
- 297 people
- Sponsor
- CTC Bio, Inc.
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO
The SURVIVE trial aims to test whether using an anti-thrombotic regimen involving cangrelor can reduce bleeding risk while maintaining effective antithrombotic effects in patients on VA-ECMO due to cardiogenic shock (CS)/ cardiac…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Platelet Dysfunction
- Trial name
- SURVIVE (NCT06792643)
- Testing
- Cangrelor
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity
From Blast Injury to Multicompartment Dysfunction:
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect…
- Conditions
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity, Compartment Syndromes
- Trial name
- BLAST-PCS (NCT07911085)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Duchenne Muscular Dystrophy
Safety and Efficacy of P-188 NF in DMD Patients
This is an open-label study to evaluate the safety, tolerability and efficacy of daily, subcutaneous dosing with P-188 NF (Carmeseal-MD™) in non-ambulatory boys with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT03558958
- Testing
- P-188 NF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Phrixus Pharmaceuticals, Inc.
Pelvic Organ Prolapse, Sexual Function Abnormal
Four-arm Mesh for Vaginal Stump Prolapse
To estimate the safety and efficacy of performing modified anterior transvaginal mesh surgery using polypropylene mesh for treatment of advanced urogenital prolapse after hysterectomy (stage III and IV vc Pelvic Organ Prolapse…
- Trial name
- NCT03809806
- Testing
- 4-arm polypropylene mesh surgery, The Female Sexual Function Index (FSFI) questionnaire, King Health Questionnaire (KHQ)
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Lublin
Bladder Dysfunction, Neurogenic Bladder Dysfunction
Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
Neurogenic lower urinary tract dysfunction is common among people with Multiple sclerosis with a pooled prevalence of 68.41% using self-report measures and 63.95% using urodynamic studies.
- Conditions
- Bladder Dysfunction, Neurogenic Bladder Dysfunction, Urinary Incontinence, Urinary Bladder, Overactive
- Trial name
- NCT04528784
- Testing
- Transcutaneous tibial nerve stimulation
- Where
- Ireland
- Volunteers
- 23 people
- Sponsor
- University of Limerick
Stroke, Upper Extremity Dysfunction
Effects of Combined vs. Sequential Attentional Focus Instructions on Upper Extremity Function in Subacute Stroke
Stroke is a leading cause of long-term disability, and upper extremity impairments-affecting about 80% of survivors-limit functional reach, grasp, and manipulation more severely than lower limb deficits.
- Conditions
- Stroke, Upper Extremity Dysfunction, Cue, Threat
- Trial name
- NCT07289308
- Testing
- Combined Focus of Attention Instructions, Sequential Focus of Attention Instructions, standart rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bahçeşehir University
Scapula Fracture, Glenoid; Fracture
Clinical Outcomes Following Glenoid Neck Fracture as Correlated With Quantitative Assessment of Osseous Injury
A significant subset of patients with scapula fractures also involves the glenoid neck (bone joining the shoulder joint the scapular body).
- Trial name
- NCT00644813
- Testing
- Scapular with glenoid neck fractures
- Where
- 13 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Boston Medical Center
Stroke, Upper Extremity Dysfunction
I2-CoRT WTP9: Upper Extremity Motor Intervention, Use of Hand Orthosis in People Post-stroke
The upper extremity kinematics of people post-stroke will be monitored with/without an inactive hand orthosis (intervention: added weight to hand) during ARAT, Fugl-Meyer, and Box and Blocks tests.
- Trial name
- NCT04265079
- Testing
- Additional weight at hand
- Sponsor
- Maastricht University
Diaphragm Elevated, Paresis
FOT Assessment of Hemi-diaphragm Dysfunction After Upper Extremity Nerve Blocks
Upper extremity nerve blocks of the brachial plexus using local anesthetic can inadvertently affect the ipsilateral phrenic nerve and result in hemidiaphragm dysfunction.
- Trial name
- NCT04005235
- Testing
- Thorasys Tremoflo C-100 Airwave Oscillometry System (FOT)
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Nova Scotia Health Authority
Cognition Disorders in Old Age
Study on the Effectiveness and Safety of Two Olive Extract- Based (Olea Europea L. Folium) Supplements, Alone or Combined With a Mullein Extract (Verbascum Thapsus L. Herba Cum Floribus), for the Maintenance of Cognitive Function.
The goal of this clinical trial is to learn if two food supplements based on olive leaf extract, alone or combined with mullein extract, help maintain cognitive function in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07586410
- Testing
- ACTIVE TREATMENT 1 - OLI-COGNITIVE FOOD SUPPLEMENT, ACTIVE TREATMENT 2 - OLI-VERB-COGNITIVE FOOD SUPPLEMENT
- Where
- Italy
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- ISTITUTO FARMOCHIMICO FITOTERAPICO: EPO SRL
Spinal Cord Injury Cervical, Upper Extremity Dysfunction
Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury
Stimulation of the spinal cord may induce the growth and reorganization of neural pathways leading to the re-animation of paralyzed limbs.
- Trial name
- ADDRESS (NCT03184792)
- Testing
- Transcutaneous spinal stimulation, Physical therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Meibomian Gland Dysfunction, Dry Eye
Evaluating Impact of Systane iLux on Dryness Symptoms and Wearing Time in Contact Lens Users
To evaluate dry eye symptoms and contact lens wearing times after a single iLux treatment by evaluating change from baseline in OSDI scores, subjective CLDEQ8 and CL wearing time questionnaires, and meibomian gland secretion…
- Trial name
- NCT05306561
- Testing
- Systane iLux thermal pulsation treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Periman Eye Institute
Erectile Dysfunction
Study the Effect of Avanafil on the Pharmacodynamics and Pharmacokinetics of Warfarin in Healthy Male Subjects
This study is designed to look into the effect of avanafil on blood levels of warfarin and to investigate its effect on prothrombin time/international normalized ratio (INR) in healthy men.
- Trial name
- NCT01095588
- Testing
- 200 mg Avanafil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Premature Ejaculation
Exploratory Study of Pagoclone in Men With Premature Ejaculation.
The purpose of this study is to evaluate pagoclone in the treatment of premature ejaculation.
- Trial name
- NCT00370981
- Testing
- pagoclone
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Orthotic Devices, Electromyography
Biomechanical Analysis of the Effects of Upper Limb Orthosis During the Execution of a Functional Task
The orthotics are auxiliary therapeutic resources indicated for the relief of pain, improves functional standard or correction of deformities.
- Conditions
- Orthotic Devices, Electromyography, Biomechanical Phenomena, Hand
- Trial name
- NCT02966990
- Testing
- Hand Orthotic Devices
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo
Sexual Dysfunction, Upper Extremity Trauma
Sexual Dysfunction Following Upper Extremity Trauma
Hypothesis 1. The prevalence of sexual dysfunction after upper extremity function in adults (>18yo) is higher than the general population in the early post-operative period (3mo) and at 1 year post-operatively. 2.
- Trial name
- NCT04764578
- Sponsor
- Vanderbilt University Medical Center
Spasticity as Sequela of Stroke, Spastic Hemiplegia
Modulation of Upper Limb Spasticity Post-Stroke
Stroke is one of the commonest causes of severe disability in adults. Stroke often results in spasticity and motor impairments in the upper limb.
- Conditions
- Spasticity as Sequela of Stroke, Spastic Hemiplegia, Upper Extremity Dysfunction
- Trial name
- NCT05069480
- Testing
- Virtual reality-based training equipment., Traditional physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 38 people
- Sponsor
- Umm Al-Qura University
Stroke, Spinal Cord Injuries
ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)
The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems.
- Conditions
- Stroke, Spinal Cord Injuries, Brain Injuries, Traumatic, Movement Disorder, Upper Extremity
- Trial name
- NCT07749625
- Testing
- ZEPU-AI2, ZEPU-AI4, ZEPU-AI6 Plus
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University