Clinical trials: Upper Limb Surgery
Hepato Cellular Carcinoma
Ebastine for Adjuvant Treatment of Tumor Budding-Positive Liver Cancer After Surgery
This study evaluates ebastine, an FAK (focal adhesion kinase) inhibitor, as adjuvant therapy to reduce the risk of recurrence in patients with hepatocellular carcinoma (HCC) who have undergone curative hepatectomy and whose…
- Trial name
- NCT07734766
- Testing
- Ebastine
- Volunteers
- 45 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Upper Extremity Trauma
Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi
Effective post-operative pain control can reduce patient morbidity and affect the patient outcome. Brachial plexus block is one of them, a popular and widely employed regional nerve block technique for perioperative anesthesia…
- Trial name
- NCT03372486
- Testing
- Bupivacaine plus naloxone, Bupivacaine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Mansoura University
Solid Tumors, Identified by NGS, PCR or IHC
Study of Pembrolizumab Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors
The purpose of this study is to test the safety of the study drug, pembrolizumab, and to find out how well it works to prevent cancer from coming back in people who have had a solid tumor surgically removed, but still have tumor…
- Trial name
- NCT03832569
- Testing
- Pembrolizumab
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer (Early Breast Cancer)
A Study on the Treatment of Early Small Breast Cancer With Ultrasound-guided Vacuum-assisted Excision Combined With Surgery
The aim of this clinical trial is to assess the feasibility and safety of ultrasound-guided vacuum-assisted excision (VAE) in the treatment of early breast cancer with Tis (carcinoma in situ) or T1 (maximum tumor diameter ≤2cm)…
- Trial name
- NCT07071402
- Testing
- Ultrasound-guided vacuum-assisted excision combined with surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Pain Management, Anaesthesia Complication
Efficacy of Variable Volume Truncal Blocks in Upper Limb Orthopedic Surgery
aim of this study is to compare the effect of selective truncal blocks, performed at different doses and volumes, on the onset times of motor and sensory blocks required for anesthesia in patients scheduled for hand, wrist…
- Trial name
- NCT06664203
- Testing
- Selective turuncus block with 25 ml bupivacain, Selective turuncus block with 15 ml bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Glioblastoma, Malignant Glioma
Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults
This phase I trial studies the side effects of nivolumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive).
- Conditions
- Glioblastoma, Malignant Glioma, Recurrent Glioblastoma, Recurrent Malignant Glioma
- Trial name
- NCT04323046
- Testing
- Nivolumab, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 20 sites in United States, Australia
- Volunteers
- 9 people
- Sponsor
- Sabine Mueller, MD, PhD
Right-sided Colon Cancer
RISE Ileocecal Valve Functional Reconstruction
The traditional surgical treatment for right-sided colon cancer involves the removal of an important structure, the ileocecal valve, which includes the ileocecal valve.
- Trial name
- NCT07167420
- Testing
- RISE (Revolute Insert Side-End ileocecal valve reconstruction)
- Volunteers
- 188 people
- Sponsor
- Army Medical University, China
Fracture at Wrist and/or Hand Level, Rupture of Tendon of Wrist and Hand
USG Brachial Plexus Block for Upper Extremity Surgery
Ultrasound-guided (USG) brachial plexus (BP) block efficacy at the Supraclavicular (SCL), Lateral- Infraclavicular (LIC) and Axillary (AX) level: Randomized, observer-blinded study of the single-penetration…
- Conditions
- Fracture at Wrist and/or Hand Level, Rupture of Tendon of Wrist and Hand, Injuries to the Wrist, Hand and Fingers (S60-S69), Ganglion Cysts
- Trial name
- NCT01993290
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Jens Borglum Neimann
Prostatectomy, Cystectomy
Hugo™ RAS Urology Post-Market Clinical Study
The purpose of this study is to collect evidence on the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Prostatectomy, Cystectomy, Nephrectomy, Urologic Cancer
- Trial name
- NCT07901049
- Testing
- Robotic Assisted Urologic Surgery
- Volunteers
- 110 people
- Sponsor
- Medtronic - MITG
Hemorrhage, Urgent Surgery
Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure
This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who…
- Conditions
- Hemorrhage, Urgent Surgery, Invasive Procedure
- Trial name
- REVERSE-IT (NCT04286438)
- Testing
- Bentracimab (PB2452) Infusion
- Where
- 68 sites in United States, Austria and 11 more
- Volunteers
- 226 people
- Sponsor
- SFJ Pharmaceuticals, Inc.
Early Gastric Cancer
LECS Combined With LSNNS for Early Gastric Cancer (LENS Trial)
Early gastric cancer (EGC) is traditionally treated with either endoscopic resection or standard laparoscopic gastrectomy with formal lymph node dissection.
- Trial name
- LENS (NCT07857668)
- Testing
- Procedure: LECS combined with LSNNS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Spasticity, Muscle, Spinal Cord Injuries
Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity Treatment
Spasticity - a variety of motor over-activity and part of the upper motor neuron syndrome - is a common cause of impaired motor function after brain injuries of different etiologies.
- Conditions
- Spasticity, Muscle, Spinal Cord Injuries, Traumatic Brain Injury, Stroke
- Trial name
- NCT03910101
- Testing
- Hand surgery and intensive rehabilitation
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Vastra Gotaland Region
Postoperative Pain
Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia
Dexamethasone has an evidence-based indication in postoperative emesis prophylaxy and as a antiinflammatory steroid. Although the perineural administration is off-label, several studies recognised its analgetic action as an…
- Trial name
- NCT02698995
- Testing
- Dexamethasone, Ropivacaine, Paracetamol
- Where
- Romania
- Volunteers
- 180 people
- Sponsor
- Foisor Orthopedics Clinical Hospital
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Inflammatory Bowel Diseases, Surgery
Perioperative Monitoring to Assess Preoperative Anxiety in Inflammatory Bowel Disease Patients
Anxiety and depression are extremely common among Inflammatory Bowel Disease (IBD) patients undergoing surgery and may increase the risk of postoperative adverse outcomes.
- Trial name
- PeRseo (NCT06299423)
- Testing
- Howdy Senior® device
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Clinico Humanitas
Oropharyngeal Squamous Cell Carcinoma, Supraglottic Squamous Cell Carcinoma
Efficacy and Safety of TORS for SCCA
The purpose of this study is to learn more about the outcomes of treatment of throat and voice box cancers using transoral robotic surgery (TORS).
- Trial name
- NCT01819480
- Testing
- Transoral robotic surgery
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Katherine L Fedder
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Lateral Epicondylitis
Comparing Surgical and Nonsurgical Outcomes of Tennis Elbow
Tennis elbow is a condition that causes pain on the outside of the elbow, typically caused by motions involving straightening of the arm.
- Trial name
- NCT07885280
- Testing
- Conservative Arm, Surgical
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Reconstructive Surgery
Lateral Arm Free Flap: a Useful Flap in the Maxillo-facial Surgeon's Therapeutic Armory, Case Series
Lateral arm free flap harvesting has been well described, it however remains underused compared to other free flaps such as radial forearm and anterolateral thigh free flap.
- Trial name
- NCT06447610
- Testing
- Lateral arm free flap
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- CHUV chirurgie orale et maxillofaciale
Analgesia
Tourniquet Pain Prevention During Distal Upper Limb Surgery
Post-tourniquet pain remains a common problem. It disturbs the quality of anesthesia during brachial plexus block for distal upper-limb surgery.
- Trial name
- NCT07784426
- Testing
- Selective ultrasound guided Intercostobrachial nerve block, Serratus anterior plane block
- Volunteers
- 90 people
- Sponsor
- Zagazig University