Clinical trials: Urethral Stricture, Male
Urethral Stricture
Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty
Buccal mucosa urethroplasty is a current fashion in urethral stricture management. In our university centre (Hospital de Clínicas de Porto Alegre) is a common surgical treatment choice.
- Trial name
- NCT03973619
- Testing
- Labial Graft, Jugal Graft
- Volunteers
- 77 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Urethral Stricture, Urethral Diseases
REDUCER Trial (TXA in Urethroplasty)
This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty.
- Trial name
- REDUCER (NCT07501884)
- Testing
- Tranexamic Acid, Urethroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Amjad Alwaal, MD, MSc, FRCSC, FACS
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Urethral Stricture
The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients
Regenerative surgery is an emerging multidisciplinary field actually based on derived adipose tissue. Autologous fat grafting was first described by Neuber in 1893 and since then it has developed over the next century.
- Trial name
- LSNanofat (NCT05464290)
- Testing
- NANOfat grafting
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Urethral Stricture, Male
Laser Visual Internal Urethrotomy With Versus Without Paclitaxel Injection
To evaluate the outcome of visual internal urethrotomy in treating urethral strictures in males with a holmium: yttrium-aluminium garnet (YAG) laser versus when combined with intralesional injection of paclitaxel.
- Trial name
- NCT06123520
- Testing
- Ho-YAG Laser Visual internal urethrotomy, Ho-YAG Laser Visual internal urethrotomy combined with intralesional submucosal injection of Paclitaxel
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Urethral Stricture
Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
The study described below is designed to assess the safety and device performance for the drug coated balloon (DCB) for the treatment of urethral stricture.
- Trial name
- ROBUST-II (NCT03270384)
- Testing
- Urotronic Drug Coated Balloon (DCB)
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Urotronic Inc.
Anterior Urethral Stricture, Male
Optilume Registry for Treatment of Stricture of the Anterior Urethra
The purpose of this registry is verifying the continued safety and effectiveness of the Optilume DCB clinical use in patients undergoing dilation of the urethral stricture.
- Trial name
- NCT05479422
- Where
- 13 sites in Belgium, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- European Association of Urology Research Foundation
Urethral Stricture
Platelet Rich Plasma Versus Mitomycin C Injection Following Visual Internal Urethrotomy in Urethral Stricture
this is a randomized clinical trial that was conducted at Ain Shams University to compare the effectiveness and safety of two different substances injected after visual internal urethrotomy for treating urethral stricture in…
- Trial name
- NCT07883837
- Testing
- Visual internal urethrotomy followed by submucosal intralesional mitomycin C injection, Visual internal urethrotomy followed by submucosal Platlet Rich Plasma injection
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Urethral Stricture
Liposomal Bupivacaine To Control Post-Operative Pain Following BMG
This is a single blinded-randomized controlled trial that recruit male patients for substitution urethroplasty using buccal mucosal graft.
- Trial name
- NCT03720223
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Urology of Virginia
Hypospadias Repair
Hemostasis During Hypospadias Surgery
A comparison between the two hemostatic methods of hypospadias repairing operation, in terms of early and mid-term (up to 6 months) failure rate (wound dehiscence and urethral stricture needing reoperation) between the two…
- Trial name
- NCT02268019
- Testing
- tourniquet application, epinephrine injection
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Urethral Stricture
ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease
ROBUST III is a prospective, multi-center, randomized controlled adaptive sample size clinical trial to establish the safety and effectiveness for the Optilume Stricture Drug Coated Balloon (DCB).
- Trial name
- ROBUST-III (NCT03499964)
- Testing
- Optilume Drug Coated Balloon (DCB), Control Treatment
- Where
- 22 sites in United States, Canada
- Volunteers
- 127 people
- Sponsor
- Urotronic Inc.
Urethra Stenosis
DoVe Trial: Dorsal Onlay Versus Ventral Onlay in Isolated Bulbar Urethral Strictures
For bulbar urethral strictures, it remains unclear whether ventral onlay graft urethroplasty is non-inferior to dorsal onlay graft urethroplasty in terms of patency rates.
- Trial name
- DoVe (NCT04551417)
- Testing
- Free graft urethroplasty
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- University Hospital, Ghent
Urethra Stenosis, Urethral Stricture
Multi-stage Urethroplasty with Augmentation Using a Dorsal Graft Inlay Technique Comparing Graft Use in First or Second Stage
The principal aim of this pilot study is to directly compare both approaches and analyze the failure rate after one year of follow-up.
- Trial name
- MAGIC I (NCT04965025)
- Testing
- Multi-stage urethroplasty with graft inlay in first stage, Multi-stage urethroplasty with graft inlay in second stage
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture
Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft
This is a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DoVeBuG (NCT02551783)
- Testing
- Urethroplasty with buccal mucosa graft, Ventral Buccal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Urethral Stricture
Clostridium Histolyticum Collagenase Injection for Urethral Disease
The purpose of this study is to assess the efficacy of clostridium histolyticum collagenase (XIAFLEX®) in treating urethral strictures.
- Trial name
- NCT02948842
- Testing
- Clostridium Histolyticum Collagenase, Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of South Florida
Urethral Stricture
Nanofat Grafting in Male and Female Subjects Affected by Urethral Strictures
In 2001 Zuk showed that lipoaspirate contains multipotent adipose stem cells (ADSCs) like in the bone marrow, thereby expanding opportunities in multiple fields.
- Trial name
- NFUS (NCT05451732)
- Testing
- Nanofat grafting
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Roma La Sapienza
Urologic Diseases, Male Urogenital Diseases
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males.
- Conditions
- Urologic Diseases, Male Urogenital Diseases, Urethral Stricture, Urethral Injury
- Trial name
- NCT03258658
- Testing
- Autologous Engineered Urethral Construct
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Penile Skin, Buccal Mucosal Graft
Penile Skin Versus Buccal Mucosal Graft in Augmentation Urethroplasty for Long Anterior Urethral Stricture
The aim of this study is to analyze the outcomes of dorsal onlay buccal mucosal graft (BMG) and penile skin graft (PSG) urethroplasty in the management of long segment bulbar urethral stricture.
- Conditions
- Penile Skin, Buccal Mucosal Graft, Augmentation, Urethroplasty
- Trial name
- NCT07074717
- Testing
- Buccal Mucosal Graft (BMG) Urethroplasty, Penile Skin Graft (PSG) Urethroplasty
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Pain, Postoperative, Urethral Stricture
Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty
The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior…
- Trial name
- NCT03859024
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Stricture Urethra
Role of Paclitaxel in Stricture Urethra
Stricture urethra is a common disease and has various causing factors. The most common performed procedure is direct visual internal urethrotomy (DVIU), but unfortunately has a high recurrence rates.
- Trial name
- NCT05678413
- Testing
- DVIU with paclitaxel injection, DVIU
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University