Clinical trials: Uric Acid Stones
Uric Acid Stones, Hyperuricemia
Role of Uralyt-U in Patients With Hyperuricemia
The purpose of the study is to provide a more direct and objective basis for the widespread use of potassium sodium hydrogen citrate granules in the treatment of uric acid stones.
- Trial name
- NCT04352153
- Testing
- Febuxostat, Uralyt-U
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Ai Peng
Obesity, Uric Acid Stones
Phentermine/Topiramate for Uric Acid Stones
The investigator proposes an 18 month, feasibility pilot study, randomizing obese and diabetic individuals with pure uric acid nephrolithiasis (UAN) or mixed calcium oxalate (CO) UAN to either phentermine/topiramate or a…
- Conditions
- Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes
- Trial name
- NCT04621929
- Testing
- Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Uric Acid Stones
Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers
The incidence of kidney stone disease continues to rise globally. Although the treatment of kidney stone disease has dramatically improved in recent years, surgical management remains invasive and expensive.
- Trial name
- NCT06335537
- Testing
- Potassium citrate, Sodium bicarbonate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Irvine
Hyperuricemia, Gout
Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial
The purpose of this study was to test the effect of chronic consumption of Quercetin 500 mg tablets on blood uric acid and other biomarkers in adult males.
- Conditions
- Hyperuricemia, Gout, Kidney Calculi, Diabetes
- Trial name
- NCT01881919
- Testing
- Treatment, Control
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Urinary Tract Stones
Multicenter Study to Develop a Model to Identify Uric Acid Urinary Tract Stones Using CT and Lab Tests
Urinary tract stones are a common condition affecting the kidney, ureter, bladder, and urethra. Uric acid stones represent an important subtype of urinary stones and require different prevention and treatment strategies compared…
- Trial name
- UAS-Model (NCT07328932)
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 1,650 people
- Sponsor
- Jian Zhuo
Nephrolithiasis, Uric Acid
Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss
The investigators will randomize overweight and obese iuan patients to Pio (45 mg/day, highest approved dose or placebo), WL (10% of body weight, following the established program used in the Diabetes Prevention Program), or…
- Trial name
- NCT04370093
- Testing
- Pioglitazone 45 mg, Weight Loss, Pioglitazone + Weight Loss
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Uric Acid Stones
Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation
Patients who are overweight or obese, diabetic or not, share with those who are suffering from uric stones the same way to remove abnormal acidity of the body in urine, ie a kidney ammoniogenesis default.
- Trial name
- NCT02561858
- Testing
- acid load test
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Urolithiasis, Stone Ureter
A Randomized Clinical Trial to Evaluate the Effectiveness of Oral Potassium Citrate in Preventing Ureteral Stent Encrustation in Patients Undergoing Ureteroscopy for Uric Acid Kidney Stones
This randomized clinical trial aims to evaluate the efficacy of oral potassium citrate in reducing ureteral stent encrustation following ureteroscopy for uric acid kidney stones.
- Trial name
- NCT06819553
- Testing
- Oral Potassium Citrate
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Uric Acid Stones
The Effective of Potassium Sodium Hydrogen Citrate in Treating Uric Acid Stones Using Gut Microbiota and Metabolomics.
The goal of this observational study is to investigate the alterations in gut microbiota and metabolites among patients with uric acid stones following the administration of potassium sodium hydrogen citrate.
- Trial name
- NCT06118320
- Testing
- Potassium sodium hydrogen citrate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cheng Cao
Uric Acid Kidney Stone Disease
Pathophysiology of Uric Acid Nephrolithiasis
This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results.
- Trial name
- IUAN (NCT00904046)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Texas Southwestern Medical Center
Urolithiasis, Renal Stones
The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation
The aim of the study is to evaluate the predictors of success of oral dissolution therapy in radiolucent renal stones in a large series of patients from a tertiary referral center in order to define the optimum case scenarios…
- Trial name
- NCT02373384
- Testing
- Oral alkalinization (Potassium citrate, Allopurinol), Life style modification, Dietary recommendations (decrease purine rich diet as red meat and fish, increase vegetables)
- Where
- Egypt
- Volunteers
- 182 people
- Sponsor
- Mansoura University
Hypouricemia, Renal, Urolithiasis
A Randomized Clinical Trail of The Effect of Postoperative Uric Acid Control on Stone Recurrence and Renal Function in Patients With Hyperuricemia of Urolithiasis.
The purpose of this study was to explore the effects of uric acid control on stone recurrence and renal function in patients with calculi of hyperuricemia through a prospective controlled study.
- Trial name
- NCT04398251
- Testing
- Febuxostat 40mg Tab, Non-drug control group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xuhui Central Hospital, Shanghai
Uric Acid Nephrolithiasis
Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)
The investigators will test the hypothesis that renal uptake of free (i.e. non-esterified) fatty acids (FFa) is increased in iuan.
- Trial name
- IUAN (NCT02975986)
- Testing
- 123I-BMIPP, 99mTc-MAG3
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Renal Stone, Urinary Stones
Uric Acid Based Renal Stones: Clinical, Metabolic and Genetic Characterization
Reporting prevalence of uric acid based renal stones among patients with nephrolithiasis admitted to Mansoura Urology and Nephrology center (MUNC). Furthermore, identification of monogenic and polygenic uric acid stone formers.
- Trial name
- NCT05634434
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University