Clinical trials: Urinary System Disorder
Healthy Volunteers, Polycystic Kidney, Autosomal Dominant
Effect of Venglustat in Patients With Renal Impairment
Primary Objective: To study the effect of mild, moderate and severe renal impairment on the pharmacokinetics (PK) of Venglustat following a single dose.
- Trial name
- NCT03687554
- Testing
- Venglustat GZ/SAR402671
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genzyme, a Sanofi Company
Urinary Bladder Neoplasms, Microtia
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder
Microbes inhabiting the urinary tract that are playing an important role in maintenance of health and the development of diseases and bladder cancer. There is correlation between initiation of bladder cancer and microbes.
- Trial name
- Cancer bladder (NCT06289283)
- Testing
- Urine samples and tissue samples: Samples will be collected in clean leak-proof containers without disinfectant or detergent residue and with tight-fitting leak-proof lids and preserved in a refrigera
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Ureteral Calculi
Comparing Uretersocopy With Versus Without Use of Guide-wire in Treatment of Ureteral Stone
The purpose of this study is to compare ureteroscopy with and without use of safety guide-wire in treatment of ureteral stone
- Trial name
- NCT03726502
- Testing
- ureteroscopy with safety guide-wire, ureteroscopy alone, without safety guide-wire
- Where
- Iran
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Kidney Neoplasms
A Study to Evaluate the Safety and Efficacy of Nivolumab With Ipilimumab in Participants With Untreated Advanced Kidney Cancer Conducted in India
The purpose of this study is to assess the safety and efficacy of nivolumab combined with ipilimumab in intermediate and poor-risk participants with previously untreated advanced renal cell carcinoma (RCC) or metastatic RCC…
- Trial name
- CheckMate 7C9 (NCT04513522)
- Testing
- Nivolumab, Ipilimumab
- Where
- 11 sites in India
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
This phase 1B trial tests the safety, side effects and best dose of rh-Hsc70- BZLF1 peptide complex (OSU-2131) with Stimulon (Trademark) QS-21 and evaluates how well it works in preventing Epstein-Barr virus (EBV) infection and…
- Conditions
- Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5, EBV-Related Lymphoproliferative Disorder, EBV-Related Malignant Neoplasm
- Trial name
- NCT06741072
- Testing
- Biospecimen Collection, Dulbecco''s Phosphate-Buffered Saline, Peptide Vaccine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Fabry, Renal Disease
Relation Between Polymorphism in Genes Related to Kidney Disease and Renal Manifistations in Fabry Disease
The rational of the study is to try to predict which of the patients who suffer from Fabry disease will have End Stage Renal Disease.
- Trial name
- NCT00437944
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Interstitial Cystitis/Painful Bladder Syndrome, Myofascial Pelvic Pain
Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) Study
Interstitial cystitis/painful bladder syndrome (IC/PBS) causes severe bladder pain and extensive disability in a large group of women int he prime of their productive lives.
- Trial name
- ICEPAC (NCT01616992)
- Testing
- Bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Chronic Kidney Disease
A Study to Assess the Safety and Pharmacokinetics of Verinurad and Allopurinol in Asian and Chinese Subjects
This is a randomized, placebo controlled, double-blind study with two separate cohorts to assess safety, tolerability and pharmacokinetics of verinurad and allopurinol in healthy subjects.
- Trial name
- NCT03836599
- Testing
- Verinurad, Allopurinol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Polycystic Ovary Syndrome, Hyperandrogenism
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia
Polycystic ovary syndrome (PCOS) is a common disorder marked by hyperandrogenism, oligo-/anovulation, and subfertility. The precise causes of PCOS are unclear, but the pathophysiology involves complex genetic and environmental…
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Puberty
- Trial name
- DENND1A (NCT02611128)
- Testing
- Phenotype/genotype assessment
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chronic Kidney Diseases, Dialysis; Complications
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the…
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Sodium Retention
- Trial name
- NCT04848636
- Testing
- Cardiac Sodium and Proton MRI
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Urolithiasis, Nephrolithiasis
Does Treatment With Alfuzosin Increase Success Rates of (SWL) Shock Wave Lithotripsy
In latest literature more evidence is available about the positive effect of alpha blocker on stone expulsion from the ureter. Patients benefit from less pain and shortening time to stone expulsion.
- Conditions
- Urolithiasis, Nephrolithiasis, Ureterolithiasis
- Trial name
- NCT00409227
- Testing
- Alpha blocker-alfuzosin
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Overactive Bladder Syndrome
Prevalence And Risk Factors of Overactive Bladder Syndrome Among Egyptian Medical Students, and Their Impact On Health-Related Quality Of Life
Overactive bladder (OAB) is defined as sudden, urgent desire to urinate (urgency) accompanied by frequency and nocturia, with or without urgent urinary incontinence in the absence of urinary tract infection (UTI).
- Trial name
- NCT07044778
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Benign Prostatic Hypertrophy With Outflow Obstruction, Overactive Detrusor
Prognostic Value of the Urinary Nerve Growth Factor in the Patients With Benign Prostatic Hyperplasia
Persistent detrusor overactivity (DO) after transurethral prostatectomy results in symptomatic failure in more than one third of the patients.
- Trial name
- NCT01781117
- Testing
- Holmium Laser Enucleation of the Prostate (HoLEP), Holmium laser enucleation system and morcellator
- Where
- South Korea
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- KYU-SUNG LEE
Cancer, Renal Failure
Fernald Community Cohort -18 Year Observational Study
The Fernald Community Cohort consists of the 9782 persons who were enrolled in the Fernald Medical Monitoring Program (FMMP) (1990-2008).
- Conditions
- Cancer, Renal Failure, Diabetes, Cardiovascular Disease
- Trial name
- FCC (NCT02295085)
- Where
- United States
- Volunteers
- 9,782 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Acute Kidney Injury
Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury
The current international Continuous Renal Replacement Therapy (CRRT) replacement fluid doses of 35 ml/kg/h is better, but the result is according to white people, black people .
- Trial name
- NCT01560650
- Testing
- CRRT
- Where
- China
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Wei Shi
Gastrointestinal Diseases, Chronic Pain
Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine
The investigators are inviting people with fibromyalgia, IBS, interstitial cystitis, chronic pain, and other chronic and recurring conditions to sign up and participate in a year-long Internet-based survey to study the…
- Conditions
- Gastrointestinal Diseases, Chronic Pain, Stress, Anxiety
- Trial name
- PROCAIM (NCT00740233)
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Overactive Bladder, Caffeine
"The Effects of Caffeine on Overactive Bladder Symptoms and Mental Health in Postmenopausal Women"
The purpose of this study is to observe effects of caffeine on overactive bladder symptoms and wellbeing. This study looks at whether caffeine has bad effects on urinary symptoms or if lower doses of caffeine decrease the…
- Conditions
- Overactive Bladder, Caffeine, Menopause
- Trial name
- NCT02180048
- Testing
- 400 mg of caffeine/day (Two 200mg pills/day)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Urologic Diseases
Bioequivalence Study of the Second Generation Dutasteride and Tamsulosin HCl Combination Capsule in Fed State
The purpose of this study is to assess the bioequivalence of the second generation dutasteride and tamsulosin hydrochloride (HCL) combination capsule versus currently available commercial combination of dutasteride 0.5 milligrams…
- Trial name
- NCT02058576
- Testing
- Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg, Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intermittent Urethral Catheterization, Spinal Dysraphism
The Effect of Nursing Interventions for Clean Intermittent Catheterization Caregivers and Child
In neurogenic or non-neurogenic bladder disorders, the removal process after the catheter is inserted into the bladder and the urine has been drained is called Clean intermittent catheterization (CIC).
- Conditions
- Intermittent Urethral Catheterization, Spinal Dysraphism, Urinary Tract Infections
- Trial name
- NCT04763382
- Testing
- experimental group: Training of caregivers, Control gruop
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Diabetic Kidney Disease
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD
1. Evulate the diagnostic value of serum cathepsin S and chromogranin A for Diabetic kidney disease. 2. To correlate the levels of serum Cathepsin S and chromogranin A with HbA1c and eGFR in type 2 diabetic patients based on…
- Trial name
- NCT06069076
- Testing
- cathepsin S and chromogranin A
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Assiut University
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