Clinical trials: Urinary Tract Disease
Overactive Bladder, Urinary Urgency
Group Medical Visits for Latina Women With Urgency Urinary Incontinence
This is a mixed methods study to compare group medical visits (GMVs) to usual care for Spanish speaking Latina women with urgency urinary incontinence. Patients will be randomized to GMVs and to usual care.
- Conditions
- Overactive Bladder, Urinary Urgency, Urge Incontinence
- Trial name
- NCT03687164
- Testing
- Group Medical Visits
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Southern California
Kidney Cancer
Sunitinib Before or After Surgery in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00626509
- Testing
- sunitinib malate, adjuvant therapy, neoadjuvant therapy
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Gruppo Italiano Carcinoma Renale
Pediatric Renal Failure
Intraperitoneal Pressure Measurements Survey in Pediatric Centers
Intraperitoneal pressure (IPP) is an objective measurement used to assess tolerance to fluid volume. IPP has been shown to be strongly correlated with intraperitoneal dialysate volume as well as anthropometric parameters.
- Trial name
- IPP (NCT07339709)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Neoplasms
A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin.
- Trial name
- NCT00264433
- Testing
- ADH -1 (Exherin™)
- Where
- 11 sites in United States, Canada
- Sponsor
- Adherex Technologies, Inc.
Urinary Incontinence, Quality of Life
Pelvic Floor Symptoms and Quality of Life in Elderly Women - a Population-based Pilot Study
To assess pelvic floor symptoms and quality of life in elderly women.
- Trial name
- NCT02338726
- Testing
- Gynecological examination
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
IgA Nephropathy, Immunoglobulin A Nephropathy
Atrasentan in Patients With IgA Nephropathy
The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA nephropathy (IgAN) at risk of progressive loss of renal function.
- Trial name
- ALIGN (NCT04573478)
- Testing
- Atrasentan, Zigakibart
- Where
- 135 sites in United States, Argentina and 18 more
- Volunteers
- 404 people
- Sponsor
- Novartis Pharmaceuticals
Urinary Tract Infections, Proteinuria
Scanadu Urine Device Validation Study Protocol
This study will test Scanadu Urine Device for clinical performance and usability.
- Conditions
- Urinary Tract Infections, Proteinuria, Ketone Urine, Hematuria
- Trial name
- NCT02973178
- Testing
- Scanadu Urine Device
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Scanadu, Inc.
Carcinoma, Renal Cell
Sunitinib in Metastatic Renal Cancer
Sunitinib is the registered treatment for first-line therapy of metastatic clear-cell carcinoma of the kidney.Data from the Expanded Access Study have shown activity also in non-clear cell renal cancer (NCCRC).
- Trial name
- NCT01034878
- Testing
- Sunitinib
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Renal Cell Cancer
Bortezomib and Bevacizumab ("BB-mib-mab") in Patients With Advanced or Recurrent Renal Cell Cancer (RCC)
This research study is for subjects with cancer of the kidney (also known as renal cell carcinoma) that cannot be treated with surgery.
- Trial name
- NCT00184015
- Testing
- Bevacizumab and Bortezomib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Renal Insufficiency, Healthy
A Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Volunteers With Varying Degrees of Kidney Function
The purpose of this study is to assess the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie, how the drug affects the body) of canagliflozin (JNJ-28431754) after administration of a single dose to…
- Trial name
- NCT01759576
- Testing
- Canagliflozin (JNJ-28431754)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Prostate Cancer, Urinary Incontinence
Effect of Beta-alanine and Pelvic Floor Muscle Training on Urinary Incontinence After Radical Prostatectomy (BELA)
The purpose of this study is to evaluate the effectiveness of beta-alanine in combination with pelvic floor muscle training (PFMT) compared to PFMT plus placebo in men undergoing radical prostatectomy.
- Conditions
- Prostate Cancer, Urinary Incontinence, Beta-Alanine, Pelvic Floor Muscle Training
- Trial name
- BELA (NCT04862533)
- Testing
- Beta-Alanine, Pelvic floor muscle training (PFMT)
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Olomouc
Type 2 Diabetes, Hypertension
Effect of Pioglitazone on Cardiovascular Outcome on Higashi-Saitama Trial in Patients With Type 2 Diabetes
We want to investigate the effects of pioglitazone on cardiovascular events in Japanese patients with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Hypertension, Dyslipidemia, Diabetic Nephropathy
- Trial name
- NCT00419484
- Testing
- pioglitazone
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Dokkyo Medical University
Autoimmune Membranous Nephropathy
Peptide GAM Immunoadsorption Therapy in Autoimmune Membranous Nephropathy
Autoimmune Membranous Nephropathy is now understood to be a condition caused by the immune system although the exact mechanism is not completely known.
- Trial name
- PRISM (NCT03255447)
- Testing
- Immunoadsorption
- Where
- 3 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Kidney Disease
Behavioral Intervention and Adherence in Dialysis
The aim of the proposed work is to conduct a randomized controlled trial (RCT) evaluation of a behavior change intervention designed to enhance fluid-intake adherence (compliance) among hemodialysis patients.
- Trial name
- NCT01066949
- Testing
- Behavioral self mangement, Support and discussion
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of Iowa
Urinary Catheters, Bladder Pain and Discomfort
FLUME Catheter Comfort Study
The Flume catheter is a commercially available (FDA 510(k) cleared) urethral catheter with an innovative catheter design. The traditional Foley catheter design includes a protruding tip with drainage holes.
- Conditions
- Urinary Catheters, Bladder Pain and Discomfort, Urine Leakage, Bladder Spasm
- Trial name
- NCT05785858
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- The Flume Catheter Company Ltd
Fecal Incontinence, Anal; Sphincter, Incontinence
Severity of Fecal Incontinence and Manometric Values Using the Anopress® Device in Women
The purpose of this study is to stablish a correlation between fecal incontinence severity scales (Wexner \& St. Mark's) and manometric values obtained using the Anopress® portable manometry and values obtained using endoanal…
- Conditions
- Fecal Incontinence, Anal; Sphincter, Incontinence, Incontinence, Urge
- Trial name
- MANOPRESS (NCT05058326)
- Testing
- Portable endoanal manometry, Endoanal ultrasound, Incontinence severity scale questionaires
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Bladder Cancer
PTC-guided Neoadjuvant Therapy For Muscle-invasive Bladder Cancer
This study evaluates Patient-derived Tumor-like Cell Clusters (PTC)-guided individualized neoadjuvant therapy in patients with muscle-invasive bladder cancer who are candidates for radical cystectomy.
- Trial name
- NCT07690878
- Testing
- PTC guided individualized neoadjuvant therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Chronic Kidney Failure, Chronic Kidney Diseases
Physical Impairments in Children With Chronic Renal Failure
When the literature is examined, it is seen that the extent to which cough strength, grip strength, physical activity level and quality of life levels are affected in children with chronic kidney failure compared to healthy…
- Trial name
- NCT06981585
- Testing
- Physical Evaluations of Patients with Chronic Kidney Failure, Physical Evaluations of Healthy Children
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Renal Cancer
Multiparametric MRI for Diagnosing Small Renal Tumors
Renal cell carcinoma represents annually 3-5% of all new cancer diagnoses. To date, the standard of care for small renal masses is partial nephrectomy.
- Trial name
- IRMK01 (NCT03470285)
- Testing
- Multiparametric MR imaging (mpMRI)
- Where
- 18 sites in France
- Volunteers
- 387 people
- Sponsor
- University Hospital, Bordeaux
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
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