Clinical trials: Urothelial Cancer
Bladder Cancer, Urinary Tract Cancer
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue
Background: Urothelial cancer is cancer of the bladder, ureter, and urethra. Researchers want to better understand what changes in a person s cells and genes cause this cancer to form.
- Conditions
- Bladder Cancer, Urinary Tract Cancer, Urothelial Cancer, Healthy Volunteers
- Trial name
- NCT02379429
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Urothelial Carcinoma
Research on the Accurate Diagnosis of Urinary Tract Tumors and the Development of Kits
Bladder cancer is the second most prevalent urological malignancy worldwide, with a high incidence and poor patient prognosis. Achieving early diagnosis and intervention for bladder cancer is one of the most important ways to…
- Trial name
- NCT06193941
- Testing
- RT-qPCR
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Hematuria, Acute Cystitis With Hematuria
Women With isoLated acUte cyStitis and Macroscopic Hematuria. Is Further Investigation Needed?
This prospective multicenter observational study evaluates whether women ≥50 years with isolated acute hemorrhagic cystitis (AHC) and macroscopic hematuria require full malignancy workup.
- Conditions
- Hematuria, Acute Cystitis With Hematuria, Bladder Cancer, Urothelial Carcinoma
- Trial name
- BLUSH (NCT07037589)
- Testing
- investigation setting (cystoscopy + CTU + cytology), Cystoscopy - CTU - cytology (if needed)
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Bladder Cancer
Development of a Non-Invasive DNA Methylation-Based Assay System for the Risk Assessment of Urothelial Carcinoma
Bladder cancer ranks the ninth in worldwide cancer incidence. Approximate 90% of bladder cancer is the malignancy of urothelium tissues, the urothelial cancer (UC).
- Trial name
- NCT00867620
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Urothelial Carcinoma, Bladder Cancer
Diagnostic Evaluation of Urine DNA Methylation/Somatic Mutation Profiling for the Detection of Urothelial Carcinoma
Clinical trial to evaluate the performance characteristics(sensitivity and specificity) of AnchorDx's urine DNA methylation/somatic mutation profiling assay for detecting urothelial carcinoma compared to pathology in patients.
- Trial name
- NCT04314245
- Testing
- Active Comparator: Pathology, Active Comparator: Clinical Diagnosis, Genetic test: AnchorDx's urine DNA methylation/somatic mutation profiling assay
- Where
- China
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- AnchorDx Medical Co., Ltd.
Urothelial Carcinoma, Breast Cancer
Clinical Application of PET Imaging Targeting Nectin-4 in Malignant Tumors
This study is a diagnostic study. Patients and healthy volunteers with clinically suspected or confirmed urothelial carcinoma, breast cancer, lung carcinoma and other malignant tumors with high expression of Nectin-4 will be…
- Conditions
- Urothelial Carcinoma, Breast Cancer, Lung Carcinoma
- Trial name
- NCT06994078
- Testing
- 68Ga-NOTA-Nectin-4 antibody fragment
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Urothelial Cancer, Cancer
Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer
The purpose of this study is to determine if analysis of DNA and protein material found in urine will be useful in the detection of urothelial cancer of the bladder and kidney.
- Conditions
- Urothelial Cancer, Cancer, Bladder Neoplasms, Urinary Bladder Cancer
- Trial name
- NCT00872495
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lahey Clinic
Chromophobe Renal Cell Carcinoma, Clear Cell Papillary Renal Tumor
Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study
This study is being done to collect blood, tissue and urine samples to identify a novel high quality methylated DNA marker in patients with renal tumors.
- Conditions
- Chromophobe Renal Cell Carcinoma, Clear Cell Papillary Renal Tumor, Clear Cell Renal Cell Carcinoma, Kidney Oncocytoma
- Trial name
- NCT06339138
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 589 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Urothelial Carcinoma
Nectin-4 Specific LMW PET Probe Imaging in Urothelial Carcinoma
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with urothelial carcinoma, especially in patients with recurrent or advanced bladder cancer.
- Trial name
- NCT05321316
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Urothelial Carcinoma
DNA Methylation and Urothelial Carcinoma
Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than…
- Trial name
- NCT01378052
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Urothelial Cancer, Renal Pelvis Cancer
A Genotype-Phenotype Urothelial Cancer Registry
This study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer.
- Conditions
- Urothelial Cancer, Renal Pelvis Cancer, Ureter Cancer, Bladder Cancer
- Trial name
- NCT00902590
- Testing
- saliva sample and questionaire, saliva sample, questionaire
- Where
- 4 sites in United States
- Volunteers
- 3,519 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Upper Urinary Tract Urothelial Carcinoma, Bladder Cancer
Single-Dose Intravesical Chemotherapy After Diagnostic URS
Study design This study is a Phase III, randomized, open-label, multi-center, global study to determine the efficacy of a single immediate intravesical chemotherapy instillation (SI) in the prophylaxis of intravesical recurrence…
- Trial name
- MINERVA (NCT05810623)
- Testing
- Intravesical Solution
- Where
- 2 sites in Austria
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- David D'Andrea
Neoplasm, Ureter, Neoplasm, Bladder
Prophylactic Intravesical Chemotherapy After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Randomized Controlled Trial Between Single Postoperative Dose Versus Maintenance Therapy.
This clinical trial is designed to compare the effect of single postoperative intravesical chemotherapy instillation versus maintenance therapy on reducing bladder cancer recurrence after surgery for UTUC.
- Trial name
- NCT02438865
- Testing
- Immediate instillation of intravesical chemotherapy-Epirubicin-, Maintainance therapy of intravesical chemotherapy-Epirubicin-
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Invasive Bladder Cancer
HIPEC After Radical Cystectomy for High Risk Bladder Cancer
This is a non-randomized, non-blinded, pilot study administering hyperthermic intraperitoneal chemotherapy with Mitomycin-C in 10 men and women with muscle-invasive urothelial carcinoma of the bladder undergoing radical…
- Trial name
- NCT03514888
- Testing
- HIPEC
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Bladder Cancer, Biomarkers
Urinary Biomarkers in the Detection of Urothelial Carcinoma of the Bladder
To assess the persistence of bladder cancer-specific biomarkers in urine collected pre-operatively, in resected cancer tissue, and in urine collected post-operatively.
- Trial name
- NCT02745301
- Testing
- Collection of urine and bladder tumor specimens
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Kidney Cancer, Renal Cell Carcinoma
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different types of fuel to support tumor…
- Conditions
- Kidney Cancer, Renal Cell Carcinoma, Clear Cell Carcinoma, Urothelial Carcinoma
- Trial name
- NCT04623502
- Testing
- 13C-Glucose, 13C-Acetate, 13C-Lactate
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Urothelial Carcinoma
Phase I Study to Evaluate the Diagnostic Performance of 89Zirconium Girentuximab PET in Urothelial Cancer Patients
The aim of this study is to determine if it is practical to use 89Zr-TLX250 PET/CT in the staging and detection of localized and metastatic urothelial carcinoma or bladder cancer.
- Trial name
- ZiPUP (NCT05046665)
- Testing
- 89Zr-Girentuximab
- Where
- Australia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- South Metropolitan Health Service
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute