Clinical trials: Uterine Cervical Disease
Cervical Cancer, Ovarian Cancer
Etoposide in Treating Patients With Advanced Ovarian or Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients who have refractory…
- Trial name
- NCT00002478
- Testing
- etoposide
- Where
- 47 sites in United States
- Sponsor
- Gynecologic Oncology Group
Locally Advanced Cervical Carcinoma
Decision Aid for Chemotherapy in Cisplatin-Intolerant Patients With Locally Advanced Cervical Cancer
The goal of this clinical trial is to investigate the utility and effectiveness of a decision aid in cisplatin-intolerant patients with locally advanced cervical cancer. The main questions it aims to answer are: 1.
- Trial name
- CECIL (NCT05701735)
- Testing
- CECIL Patient Decision Aid
- Where
- 3 sites in Philippines
- Volunteers
- 45 people
- Sponsor
- University of Santo Tomas Hospital, Philippines
Cervical Cancer
Study of ZG005 in Combination With Gecacitinib in Participants With Advanced Cervical Cancer
This is a multicenter, open-label phase I/II study in patients with advanced cervical cancer designed to evaluate the safety, tolerability, and preliminary efficacy of ZG005 in combination with Gecacitinib ± bevacizumab.
- Trial name
- NCT07080216
- Testing
- ZG005, Gecacitinib, Bevacizumab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Precancerous Lesions, Conization
A Cohort Study for the Following up of Conization
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
- Conditions
- Precancerous Lesions, Conization, High Grade Intraepithelial Neoplasia, Uterine Cervical Cancer
- Trial name
- NCT03961178
- Testing
- High-risk HPV, TCT
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Cervical Dysplasia
Correlation Between Colposcopist Findings and Digital Cervicography Employing Gynescope System
Correlation between colposcopist findings and digital cervicography employing Gynescope system
- Trial name
- NCT03840187
- Testing
- Digital cervicography
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Barzilai Medical Center
Cervical Cancer, Cervical Intraepithelial Neoplasia (CIN)
Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs
The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia (CIN), Risk Factors, Conservative Management
- Trial name
- NCT06967740
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Nikola Janovska
Recurrent or Metastatic Cervical Cancer
A Study of TQB2450 Injection in Subjects With PD-L1 Positive Recurrent or Metastatic Cervical Cancer
This is a study to evaluate the efficacy and safety of TQB2450 injection in the treatment of PD-L1 positive recurrent or metastatic cervical cancer.
- Trial name
- NCT04623333
- Testing
- TQB2450
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Uterine Cervical Neoplasms
Role of Bladder Training During Post-operative Hospital Stay After Radical Hysterectomy in Patients
The objective of the study is to evaluate the impact and the outcome of bladder training during post-operative hospital stay after radical hysterectomy, mainly after neoadjuvant concurrent chemo-radiation therapy for locally…
- Trial name
- NCT01907646
- Testing
- bladder training, No bladder training
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- Catholic University of the Sacred Heart
Cervical Cancer, Cancer
The Association Between Cervical Cancer Screening and Cancer Occurrence
To investigate the protective effect of cervical cancer incidence and mortality by screening attending frequency or screening pattern, and to evaluate the possible risk of developing malignancies among women with cervical…
- Trial name
- NCT01015079
- Where
- Taiwan
- Volunteers
- 6,000,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cervical Cancer, Neoadjuvant Chemoimmunotherapy
Neoadjuvant Chemotherapy Plus Camrelizumab for FIGO Stage IB1 Cervical Cancer
This multicenter, prospective clinical trial is designed to enroll PD-L1 expression-positive patients with stage IB1 cervical cancer who desire fertility preservation to undergo neoadjuvant chemotherapy in combination with a PD-1…
- Conditions
- Cervical Cancer, Neoadjuvant Chemoimmunotherapy, Fertility Preservation
- Trial name
- NCT06289062
- Testing
- Camrelizumab, Cisplatin, Nab paclitaxel
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Intraepithelial Neoplasia, Cervical Cancer
NWRD09 for HPV-16 Positive and HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer Patients.
This is a single-arm, open label, two cohorts, multi-center clinical study to evaluate the safety and efficacy of HPV-16 targeted mRNA vaccine (NWRD09) in HPV-16 positive and HPV-16 related cervical, vaginal, and vulvar…
- Trial name
- NCT06741150
- Testing
- NWRD09 administered by intramuscular injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Newish Technology (Beijing) Co., Ltd.
Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16
HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3
Randomized, 2-arm observational study. The 2 arms (randomized at the level of health care provider) will be: 1. usual practice; 2.
- Conditions
- Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6
- Trial name
- NCT02558803
- Testing
- Simple Reminder
- Where
- 5 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- Regenstrief Institute, Inc.
Uterine Cervical Neoplasms
Exploratory Study on NIRFI Technology Combined with ICG Guided Cervical Cancer Lymph Node Metastasis
The goal of this exploratory study is to exploring the lymph node metastasis, tumor margin, blood vessels, ureters, and nerve imaging in cervical cancer surgery using near-infrared fluorescence imaging technology combined with…
- Trial name
- NCT06840418
- Testing
- Indocyanine green (ICG) injection for intraoperative lymph node imaging
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Cervical Cancer
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body.
- Trial name
- NCT07216703
- Testing
- Pembrolizumab, Sacituzumab Tirumotecan, Bevacizumab
- Where
- 191 sites in United States, Argentina and 27 more
- Volunteers
- 1,023 people
- Sponsor
- Merck Sharp & Dohme LLC
Cervical Cancer Stage IIIB, Treatment Outcome
Feasibility Study Of A Telephonic Questionnaire For Follow-Up Of Locally Advanced Cervical Cancer Patients
Cross-sectional Feasibility study on all consecutive patients of locally advanced cancer of the cervix or vault treated entirely at Tata Memorial Centre with curative intent radiation or chemoradiation.
- Conditions
- Cervical Cancer Stage IIIB, Treatment Outcome, Follow up, QUESTIONNAIRE
- Trial name
- NCT03477240
- Volunteers
- 300 people
- Sponsor
- Tata Memorial Hospital
Cancer Prevention
Accelerating the Implementation of a Breast and Cervical Cancer Screening and HPV Vaccination Intervention
The proposed study will develop and test an implementation strategy called Salud en Mis Manos-Dissemination and Implementation Assistance (SEMM-DIA) which is an internet-accessible cross-platform that includes additional…
- Trial name
- NCT05524480
- Testing
- Salud en Mis Manos - Dissemination and Implementation Assistance, Salud en Mis Manos- Usual Implementation Practice
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cervical Cancer Screening, HIV
Impact of a Single Versus Multiple Visits on the Cervical Cancer Screening Completeness, Feasibility and Acceptability Among Women Living With HIV in Cameroon
Context. Cervical cancer (CC) is a leading cause of death among women living with HIV (WLHIV) in resource-limited settings. Yet, effective methods for screening and preventing CC are available.
- Trial name
- OptiTri_GC (NCT07177170)
- Testing
- Differentiated screening delivery, Single visit
- Where
- Cameroon
- Volunteers
- 1,422 people
- Sponsor
- Institut de Recherche pour le Developpement
Cervical Dysplasia, Cervical Disease
iMproving thE DIagnostics And Treatment Of ceRvical Precancer
Cervical cancer screening is important as it enables identification of women at increased risk of the disease, but high-quality diagnostics of screen-positive women and effective treatment of those with precancer are critical in…
- Conditions
- Cervical Dysplasia, Cervical Disease, Cervical Lesion, Cervical Cancer
- Trial name
- MEDIATOR (NCT05870787)
- Testing
- Swede score colposcopy
- Where
- 7 sites in Denmark
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lymphoma, Nasopharyngeal Cancer
Applying PET/MR in Oncology - a Prospective Project
Cancer is a global health issue. According to the World Health Organization, Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018.
- Conditions
- Lymphoma, Nasopharyngeal Cancer, Esophageal Cancer, Cervical Cancer
- Trial name
- NCT04158414
- Testing
- PET/MR scan
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Uterine Cervical Dysplasia
Forced Versus Spray Coagulation in Women Undergoing LLETZ-conization for Cervical Dysplasia: a Randomized Trial
In a randomized clinical trial of 120 women undergoing large loop excision of the transformation zone (LLETZ)-conization for cervical dysplasia, two coagulation modes, spray versus forced coagulation, will be compared.
- Trial name
- CONE-1 (NCT02330471)
- Testing
- Spray, Forced
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Ruhr University of Bochum
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