Clinical trials: Vaccine Response Impaired, active
Influenza, Human, SARS-CoV-2 Infection
Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection
The objectives of this study are to understand the long-term consequences of repeated annual influenza vaccination among healthcare workers (HCWs) and to use statistical and mathematical modelling to elucidate the immunological…
- Trial name
- NCT05110911
- Testing
- Influenza vaccination: Fluarix Tetra, Vaxigrip Tetra, Fluquadri, Fluad Quad, Afluia Quad, Flucelvax Quad, SARS-CoV-2 vaccination: Comirnaty or Vaxzevria
- Where
- 6 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Vaccine Response Impaired, Respiratory Syncytial Virus Infections
RSV Vaccine in Transplant Recipients
Adjuvant, non-live RSV vaccine will be administered to adult lung and allogeneic hematopoietic stem cell transplant recipients. The safety and immunogenicity of this intervention will be studied.
- Conditions
- Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression
- Trial name
- RSVax (NCT06593210)
- Testing
- Adjuvant, non-live RSV vaccine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
COVID-19, Immunosuppression
Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients
Immunocompromised individuals, such as solid organ transplant (SOT) recipients are at high risk of COVID-19 associated complications and mortality.
- Conditions
- COVID-19, Immunosuppression, Vaccine Response Impaired
- Trial name
- ADIVKT (NCT05060991)
- Testing
- Reduction in antimetabolite immunosuppression
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, Davis
Vaccination Failure, Vaccine Response Impaired
Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?
The current recommendation for a full course of measles-mumps-rubella-(varicella) vaccine (MMR(V)) is two doses. The problem is, many individuals within the vaccinated cohort show antibody levels that are below the level…
- Trial name
- NCT05923970
- Testing
- Serology for antibody levels - Baseline, Serology to assess cell mediated immune (CMI) response - Baseline, Serology for antibody levels - Post third dose of MMR vaccine
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Immunosuppression, Vaccine Response Impaired
Safety and Immunogenicity of Recombinant Zoster Vaccine for Transplant Recipients
The goal of this clinical trial is to compare responses to Varicella Zoster vaccination between transplant patients on different medication regimens, and their healthy co-habitants. The main questions it aims to answer are: 1.
- Trial name
- SIR ZOSTER (NCT06262776)
- Testing
- Recombinant zoster vaccine adjuvanted (SHINGRIX)
- Where
- Australia
- Volunteers
- 160 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Vaccine Response Impaired
Antibiotics and Vaccine Immune Responses Study
The goal of this clinical trial is to examine immune responses to the BCG vaccine in healthy adults who have, or who have not, taken antibiotics to deplete their gut bacteria prior to vaccination.
- Trial name
- AVIRS (NCT06148025)
- Testing
- BCG vaccine, Yellow Fever vaccine, Vancomycin Oral Capsule
- Where
- Australia
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- South Australian Health and Medical Research Institute