Clinical trials: Vagal Nerve Stimulation
Cognition, Healthy Volunteers
Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognition, Dual-Task Performance, and Interoceptive Accuracy
This study aims to determine the simultaneous effects of transcutaneous auricular vagus nerve stimulation (taVNS) at two frequencies (30 Hz and 100 Hz) compared to sham stimulation on cognitive functions, dual-task performance…
- Trial name
- NCT07897175
- Testing
- taVNS 30 Hz, taVNS 100 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Toros University
Class I Obesity
Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study
This single-center randomized comparative study is designed to compare the effectiveness of tirzepatide and transcutaneous low-frequency auricular vagus nerve stimulation in adults with class I obesity and without chronic…
- Trial name
- TIFFANY (NCT07866183)
- Testing
- Tirzepatide, Transcutaneous auricular vagus nerve stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Migraine
Vagus Nerve Stimulation and Stress Reduction Training for Migraine
This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to…
- Trial name
- NCT03592329
- Testing
- Stress Reduction Training A, active tVNS, Stress Reduction Training B
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Healthy Volunteers
The Combined Effect of TENS and TaVNS on Pressure and Heat Pain Thresholds in Pain-Free Subjects
Transcutaneous electrical nerve stimulation (TENS) is a non-invasive modality that utilizes electrical currents to modulate pain in populations with acute and chronic pain.
- Trial name
- NCT06361381
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Hartford
Obesity, Craving
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Background: Obesity is one of the most important diseases around the globe; with a continuous increase and public health concern. Current treatments present some limitations.
- Trial name
- taVNS (NCT03217929)
- Testing
- Active-taVNS
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Chronic Diabetic Foot Ulcers
Pilot Study on Auricular Vagus Nerve Stimulation Effects in Chronic Diabetic Wounds
The purpose of this pilot study is to evaluate the effect of auricular autonomous nervous system stimulation on vital parameters of wound healing in diabetics.
- Trial name
- NCT02098447
- Testing
- PrimeStim
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cognitive Function
The Effect of Transcutaneous Vagus Nerve Stimulation on Cognitive Function
Cognitive health is generally considered a key component of quality of life. Current evidence indicates that a large number of individuals are at a high risk for cognitive impairment from many causes as they age.
- Trial name
- NCT04070547
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Czechia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
Traumatic Brain Injury, Hearing Loss
Improving Speech in Noise Using Noninvasive Stimulation
Traumatic brain injury, a common injury in military service personnel, often leads to poor processing of speech in noisy environments.
- Trial name
- NCT07176936
- Testing
- Cymba Conchae stimulation, Earlobe stimulation
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Florida
Major Depressive Disorder (MDD)
tVNS, Motivation, and Insulin Sensitivity
Disturbances in energy metabolism significantly increase the risk of developing major depressive disorder (MDD), especially in individuals with type 2 diabetes.
- Trial name
- NCT07198100
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Oral glucose tolerance test (oGTT)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Refractory Epilepsy
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response.
- Trial name
- BLUELIGHTVNS (NCT06304389)
- Testing
- electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration, transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Presbycusis
Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss
Hearing loss, especially for speech perception in the presence of noise, may lead older individuals to withdraw from social situations.
- Trial name
- NCT07192757
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Florida
No Condition Salivary Alpha Amylase
Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation
The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
- Trial name
- NCT03854539
- Testing
- Transdermal Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Arkansas Tech University
Rheumatoid Arthritis
Vagus Nerve Stimulation in Rheumatoid Arthritis
The purpose of this study is to examine the short-term effects of vagus nerve stimulation (VNS) by auricular stimulation (stimulation of the auricular branch of the vagus nerve which innervates the ear) in rheumatoid arthritis…
- Trial name
- NCT00859859
- Testing
- Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy Adult Participants
Exploring the Role of taVNS in Nausea Management
This single-center randomized controlled trial aims to investigate the efficacy of transcutaneous auricular vagus nerve stimulation in alleviating nausea in healthy adults.
- Trial name
- NCT07632456
- Testing
- Vagal Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Daniel Keszthelyi
Adult
LasaiON is an Evidence-informed, Multimodal Self-regulation Program Designed to Reduce Emotional Distress and Strengthen Stress-regulation Skills by Combining Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Breathing Supported by Heart-rate Variability Biofeedback (HRV-B; emWave).
The goal of this clinical trial is to evaluate whether the LasaiON program, which combines transcutaneous auricular vagus nerve stimulation (taVNS) with breathing supported by heart rate variability biofeedback (HRV-B; emWave)…
- Trial name
- LasaiON (NCT07498881)
- Testing
- LasaiON
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Vagus Nerve Stimulation, Insulin Sensitivity
Effect of Breathing Maneuvers on Peripheral Glucose Metabolism
Two important mechanisms play a major role in the pathogenesis of type 2 diabetes: insulin resistance of the target tissues and the impaired insulin secretion from pancreatic β-cells.
- Conditions
- Vagus Nerve Stimulation, Insulin Sensitivity, Deep Breathing Maneuver
- Trial name
- RESPI01 (NCT04150627)
- Testing
- deep breathing
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Sympathetic; Imbalance
Comparison of Heart Rate Variability Measurement on the Arm and Chest in Vagus Nerve Stimulation
Healthy participants will be included in this study by invitation and randomised into three groups. Participants in each group will receive bilateral transcutaneous vagus nerve stimulation with the same frequency, current transit…
- Trial name
- NCT07000175
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Vagus Nerve Stimulations, Spirometry
Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial
This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults.
- Conditions
- Vagus Nerve Stimulations, Spirometry, Autonomic Nervous System (ANS) Functioning and Mood State, Blood Pressure Monitoring
- Trial name
- taVNS-SPIRO (NCT07482930)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Vagus Nerve Stimulations
Comparison of the Acute Effects of Auricular Vagus Nerve Stimulation and Deep Breathing Exercise
The goal of this clinical trial is to investigate whether vagus stimulation and breathing exercises are more effective in healthy adults.
- Trial name
- NCT06740032
- Testing
- Transcutaneous vagus nerve stimulation, Deep breath exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University