Clinical trials: Vaginal Delivery
Labor Pain, Complications; Cesarean Section
Outcomes of Neuraxial Anesthetic Technique on the Trial of Labor After Cesarean (TOLAC)
To compare the effects of epidural versus combined spinal and epidural (CSE) anesthesia on the success of Trial of Labor After Cesarean (TOLAC).
- Conditions
- Labor Pain, Complications; Cesarean Section, Pregnancy
- Trial name
- NCT02105558
- Testing
- Epidural anesthesia, Combined spinal and epidural anesthesia
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cearean Section Rate, Maternal Adverse Outcomes
Twin Vaginal Breech Deliveries Before and After Starting Training Skills and Clinical Approach in Labor Ward
In January 2021 Dept of ObGyn of Santo Spirito Hospital Pescara Italy, and in July 2022 Dept of ObGyn of San Giovanni di Dio Hospital Florence Italy, started regular training in management of obstetric emergencies.
- Conditions
- Cearean Section Rate, Maternal Adverse Outcomes, Neonatal Adverse Outcomes
- Trial name
- TVBD (NCT06628843)
- Testing
- cesarean section rate
- Where
- 2 sites in Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
HIV Infections
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
A new approach to HIV prevention currently being studied includes the use of topical microbicides, substances that kill microbes.
- Trial name
- NCT00540605
- Testing
- Tenofovir 1% vaginal gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postpartum Hemorrhage
Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage
Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide.
- Trial name
- NCT05467462
- Testing
- I.V carbetocin administration, I.V Oxytocin administration, I.V carbetocin and tranexamic acid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Childbirth
McRoberts Manoeuvre Or Pushing Study (McMOPS)
We propose to conduct a randomised-controlled study to investigate whether adopting McRoberts' position, after 45 minutes of active pushing with no signs of progress, can increase the probability of vaginal delivery, preventing…
- Trial name
- NCT00116246
- Testing
- McRobert's manoeuvre
- Where
- Australia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Infertility, Female, Microbial Colonization
Whether Vaginal Microbiota Affects Pregnancy Outcomes After Embryo Transfer
The goal of this observational study is to learn about vaginal microbial characteristics in the patients under in vitro fertilization treatment.
- Trial name
- NCT06296615
- Where
- China
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Labor; Prolonged, Second Stage, Episiotomy Wound
The Impact of Different Skin Suture Methods in Episiotomy Repair on Healing and Pain
Episiotomy is the intentional incision of the perineum during vaginal birth in order to accelerate the active phase of labor. This study aimed to compare various skin closure techniques in episiotomy repair.
- Trial name
- NCT06379048
- Testing
- Mattress Suturing, Primary Suturing, Continuous Subcutaneous Suturing
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Vaginal Delivery
Postpartum Fatigue and Pain Versus Nutritional Status, With Epidural Analgesia
The objective of this preliminary observational study is to evaluate, in the patient, a correlation between a food habit and nutritional status score of the parturient and a postpartum fatigue (FSS) and pain (ENA) score on day 1…
- Trial name
- NCT05786911
- Testing
- nutritional score
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Charleroi
Vaginal Delivery, Surgical Site Infection
Skip Prep of Vaginal Delivery to Prevent Puerperal / Perinatal Infection in Vaginal Delivery
This is a multi-center, randomized, controlled trial study to find whether use of chlorhexidine-alcohol or povidone-iodine for pre-vaginal delivery skin prep is superior to reduce postpartum infection in pregnant women with…
- Trial name
- NCT05122169
- Testing
- Povidone-Iodine, Chlorhexidine
- Volunteers
- 4,140 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Labor Onset and Length Abnormalities
Engagement of Fetal Head as a Predictor of a Successful Vaginal Delivery in Primigravidas Presented in Early Labor.
In primigravida, Delayed engagement of fetal head has been theorized that it is more likely in women with a possible cephalo-pelvic disproportion, so far they are associated with higher risk of cervical dystocia, which led to…
- Trial name
- NCT05084326
- Testing
- Engagement of fetal head as a predictor of a successful vaginal delivery
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- mohamed abosena
HIV Infections
A Pharmacokinetic Study of Dapivirine Vaginal Rings in Belgium
IPM 018 is a double-blind, randomized, placebo-controlled study conducted at one site in Belgium among 24 healthy, HIV-negative women to evaluate dapivirine release for 28 days from matrix and reservoir intravaginal rings, each…
- Trial name
- NCT00469768
- Testing
- dapivirine reservoir intravaginal ring, dapivirine matrix intravaginal ring
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Metabolism, Drug
Comparison of Absorption of Vaginal Diazepam Using Different Delivery Systems
The purpose of this study is to determine which of three delivery systems of vaginal diazepam have the best systemic absorption, measured by serum diazepam levels.
- Trial name
- NCT01696825
- Testing
- Diazepam tablet, 5 mg, vaginal, Diazepam Suppository, 5 mg, vaginal, Diazepam Cream, 5 mg, Vaginal
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Jason Gilleran
Breastfeeding
Evaluation of Breastfeeding Success and Self-Efficacy in Mothers Giving Birth Via Vaginal Delivery or Cesarean Section
This cross-sectional observational study was conducted to compare breastfeeding success and breastfeeding self-efficacy levels of mothers who gave birth via vaginal delivery (spontaneous or via epidural analgesia) or cesarean…
- Trial name
- NCT05106634
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Nonpharmacological Method for Relief During Episiotomy Repair
The study was planned as a randomized controlled trial to evaluate the effect of reflexology on perceived perineal pain during episiotomy repair.
- Trial name
- NCT06484309
- Testing
- Reflexology Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Forceps Delivery Affecting Fetus or Newborn, Ventouse Extraction;Liveborn
Learning Curves of Different Devices for Vaginal Birth on Mannequin
Learning curves for residents and specialists for devices applied on operative vaginal birth on mannequin (Odòn, Kiwi, Simpson forceps)
- Conditions
- Forceps Delivery Affecting Fetus or Newborn, Ventouse Extraction;Liveborn, Birth; Forced
- Trial name
- NCT06923319
- Testing
- Odòn, Kiwi, Simpson skills
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Labor, Induced, Induced; Birth
Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone for Labor Induction
Acidification of vaginal pH has been proposed as a potential factor that could help increase the efficacy of vaginal prostaglandins in labor induction.
- Trial name
- NCT05100264
- Testing
- Vaginal washing with 5% acetic acid, Vaginal washing with 0.9% NS
- Where
- Greece
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
Breastfeeding
The Effect of Breastfeeding Training Given to Mothers With Vaginal Birth by Motivational Interview Technique
This study aimed to determine the effect of breastfeeding education given to mothers who gave birth vaginally using motivational interviewing technique on breastfeeding motivation, self-efficacy and attachment.
- Trial name
- NCT06313034
- Testing
- Breastfeeding education based on motivational interviewing technique
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Birth Disorder, Delivery Complication
Learning Skills in Young Specialists and Residents in Operative Vaginal Delivery Using Simulator Models
Evaluation of different learning programs on persistence of skills in operative vaginal delivery
- Trial name
- NCT05605626
- Testing
- the better retaining of skills
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University