Clinical trials: Validation Studies
Head and Neck Squamous Cell Carcinoma, Non Small Cell Lung Cancer
Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma
Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Non Small Cell Lung Cancer, Melanoma
- Trial name
- NCT04490564
- Testing
- PD-L1 Kit
- Where
- 6 sites in Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Pharmassist Ltd
Liver Diseases
Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)
The purpose of this study is to see how effective the investigators' optimized magnetic resonance spectroscopy (MRS) sequence in quantifying hepatic triglyceride content (HTGC) to enhance MRS as a diagnostic tool in non-alcohol…
- Trial name
- NAFLD (NCT00940537)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Skin Diseases
A Human In-vivo Model for the Detection of Inflammatory and Nociceptive Biomarkers
This study aims to establish a novel approach assisting the rational development of analgesic and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether proteins mediating inflammation and pain…
- Trial name
- NCT00186563
- Testing
- Micro-plasmapheresis
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Martin Angst
Reliability of National Quality Indicator Data
Data Quality of National Quality Indicators in Long-term Care Facilities: a Validation and Evaluation Study
This multiple-methods study with two data collection points (T0 and T1) aims to: 1. assess inter-rater reliability of the six national quality indicators in long-term care facilities (LTCFs) for older people in Switzerland (T0)…
- Trial name
- NIP-Q-UPGRADE (NCT06160024)
- Testing
- Program to improve data quality of national quality indicators
- Where
- 3 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Basel
Hemodynamics
Design Validation Hemodynamic Study of New Kendall SCD SmartFlow Compression System
This study is being conducted to evaluate the hemodynamic performance (i.e. flow of blood) in the legs using the new Kendall SCD SmartFlow™ compression system with Cardinal Health Element compression sleeves.
- Trial name
- NCT05945186
- Testing
- Intermittent Pneumatic Compression (IPC)(Kendall SCD SmartFlow™ compression system with Cardinal Health Element compression sleeves)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Cardinal Health
SARS-CoV
Validation of a Rapid, Non-invasive Point-of-care IVD Test for Diagnosis of SARS-COV-2 (COVID-19) Infection
A prospective non-interventional study to evaluate the performance of EASYCOV IVD as point-of-care (POC) test by comparing SARS-CoV-2 positive patients with SARS-CoV-2 negative controls on paired specimens (nasopharyngeal swabs…
- Trial name
- EasyCov (NCT04583319)
- Testing
- EasyCov POC
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Firalis SA
Early Knee Osteoarthritis
Validity and Reliability Study of the Turkish Version of the Early Osteoarthritis Questionnaire
The symptoms of early osteoarthritis (OA) are quite similar to established knee OA, they differ, particularly in frequency, intensity, and severity.
- Trial name
- NCT06388811
- Testing
- Early Osteoarthritis Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Normal and Ocular Pathology
Clinical Validation Study for iVue
To demonstrate clinical substantial equivalence of iVue as comparable to commercially available RTVue.
- Trial name
- NCT01242553
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Optovue
Body Constitution
Epidemiological Study on Body Constitution Classified by Traditional Chinese Medicine Theory
Background: Different people are classified into different physiological constitution types in the Traditional Chinese Medicine (TCM) theory.
- Trial name
- NCT03335306
- Where
- China
- Volunteers
- 6,400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Oral Cancer
Validation of DNA Methylation Biomarkers for Oral Cancer Detection-Follow up Study
This is a follow up study which aims to evaluate the correlation between several methylated genes (potential biomarkers) and oral cancers.
- Trial name
- NCT02902406
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cystic Fibrosis (CF), CFTR-related Disorders
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
Sometimes it is very difficult to tell if someone has cystic fibrosis (CF), especially when they have rare CF genes. Without this certainty, they are unlikely to get the correct treatment so their health may be affected.
- Trial name
- ADVANCE-CFTR (NCT07402434)
- Testing
- Rectal Biopsy, Rectal biopsy taken opportunistically during endoscopy procedure for other reasons., Blood test for CFTR Genotyping
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Eating Disorders, Eating Habit
Turkish Validity and Reliability Study of Reward-Based Eating Drive (RED) Scale
This research; The Turkish validity and reliability study of the "Reward-Based Eating Impulse Scale-13" developed by Ashley E. Mason was conducted to provide a new measurement tool for our country.
- Conditions
- Eating Disorders, Eating Habit, Obesity
- Trial name
- NCT05554250
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Pancreatic Cancer Stage I, Pancreatic Cancer Stage II
Clinical Validation of Immunovia Next-Generation Blood Biomarker Test to Detect Early-Stage Pancreatic Cancer
This is a case-control study to clinically validate the performance of a protein biomarker test to differentiate Stage I and Stage II pancreatic ductal adenocarcinoma (PDAC) patient samples from samples acquired from control…
- Conditions
- Pancreatic Cancer Stage I, Pancreatic Cancer Stage II, Cancer Diagnosis, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- CLARITI (NCT06947382)
- Where
- 15 sites in United States, Canada and 2 more
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Immunovia, Inc.
Hypoxia
Hypoxia Blood Validation in Multiple Pulse Oximeters
The purpose of this study is to evaluate the SpO2 accuracy and performance of multiple pulse oximeters during non-motion conditions over the range of 70-100% SaO2 as compared to arterial blood samples assessed by CO-Oximetry for…
- Trial name
- NCT00881829
- Testing
- Pulse Oximeter, Blood Pressure, Respiratory Rate, Respiratory Gasses, Temperature
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Clinimark, LLC
Reproducibility of Results, Safety Issues
Non-Invasive Blood Test Cross-Validation Study
The study considers a cross-validation approach to determine the effectiveness of a non-invasive comprehensive metabolic panel (NICMP), relative to the venipuncture method.
- Trial name
- NCT03991637
- Testing
- Non-Invasive Comprehensive Metabolic Panel
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Joseph Allen Jr.
Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD)
Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders
The World Health Organization Composite International Diagnostic Interview (CIDI) is a fully structured diagnostic tool designed for lay interviewers to assess the prevalence of mental and substance use disorders.
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Posttraumatic Stress Disorder (PTSD)
- Trial name
- NCT07604753
- Testing
- CIDI-5
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Malignant Tumor of Digestive Tract, Risk Factors
Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors
Gastrointestinal tumors (esophageal cancer, gastric cancer, colorectal cancer) seriously threaten human health, with a high incidence rate and cancer related hope mortality.
- Trial name
- NCT06118437
- Where
- China
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Androgenetic Alopecia
Harnessing Artificial Intelligence for Diagnosing Androgenetic Alopecia: A Training and Validation Study
The aim of this study is to develop and validate deep learning models in diagnosis of male and female pattern hair loss, and assessment of its severity based on clinical and trichoscopic image by handheld dermoscopy and…
- Trial name
- NCT07294313
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heart Failure, Congestive
Evaluation of MRI Measures of Lung Water With Posture Changes in Healthy Volunteers and in Patients With Cardiac Failure
The aim of this study is to establish a model for the evaluation of drug targets using postural measures to induce changes in lung water concentration as assessed by MRI.
- Trial name
- NCT01277679
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Validity and Safety
Monitor Orthopaedic Footwear Questionnaire (MOS) Validity and Reliability Study
The aim of the study is to adapt the MOS questionnaire into Turkish and to investigate the validity and reliability of the questionnaire.
- Trial name
- MOS (NCT07033390)
- Testing
- survey
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medipol University