Clinical trials: Valve
Complete Heart Block, High Degree Second Degree Atrioventricular Block
Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
The purpose of the study is to investigate the superiority of chronic left bundle branch area pacing compared to traditional right ventricular (RV) septal pacing in patients with high-grade conduction disease after transcatheter…
- Conditions
- Complete Heart Block, High Degree Second Degree Atrioventricular Block, Pacemaker-Induced Cardiomyopathy, Aortic Valve Stenosis
- Trial name
- NCT05541679
- Testing
- Right ventricular septal pacing followed by left bundle branch area pacing, Left bundle branch area pacing followed by right ventricular septal pacing
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Main Line Health
Physiological Parameter, Wearable Devices
Predicting the Clinical Advantages of Speaking Valves Through Wearable Devices
The population included in this study consists of tracheostomy patients admitted to the pulmonary department of Beijing Rehabilitation Hospital, undergoing decannulation rehabilitation treatment.
- Conditions
- Physiological Parameter, Wearable Devices, Tracheostomy
- Trial name
- NCT07587762
- Testing
- Tracheostomy patients who are able to tolerate wearing a speaking valve for 30 minutes
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Bin Zhang
Symptomatic Aortic Stenosis
ACURATE TA™ Valve Implantation: SAVI Registry (Surveillance Plan #2011-02) (TA-SAVI)
Post-market registry on ACURATE TA™ Transapical Aortic Bioprosthesis and ACURATE TA™ Delivery System implantation in patients presenting severe symptomatic aortic stenosis to provide safety surveillance of the device.
- Trial name
- NCT03143686
- Testing
- ACURATE TA™ Transapical Aortic Bioprosthesis
- Where
- 17 sites in Argentina, Germany and 2 more
- Volunteers
- 250 people
- Sponsor
- Symetis SA
Heart; Decompensation, Right Ventricle, Echocardiography
The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal…
- Conditions
- Heart; Decompensation, Right Ventricle, Echocardiography, Hypercapnia
- Trial name
- NCT02757573
- Testing
- Hypercarbia
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Tampere University Hospital
Heart Valve Replacement
The German Plug - Registry
In approximately 10-15% of all patients after surgical or interventional heart valve replacement, flapping defects appear as complications in the long-term course, so-called paravalvular / paraprothetic leaks (PVL).
- Trial name
- PLUG (NCT03179969)
- Testing
- paravalvular leak
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Valvular Heart Disease
Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery
The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery.
- Trial name
- NCT01511991
- Testing
- Sevoflurane dosage titration
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Aortic Valve Stenosis
Impact of SAVR and TAVR on Patient's Activity and Mobility
This is an independent, investigator-initiated, prospective multicenter observational study with restricted grant provided by Edwards Lifesciences that aims to describe baseline (preoperative) physical function and to assess and…
- Trial name
- CAPABILITY (NCT03843320)
- Testing
- SAPIEN 3, SAPIEN XT, INSPIRIS RESILIA
- Where
- 2 sites in Italy
- Volunteers
- 340 people
- Sponsor
- University of Padova
Aortic Valve Disease
A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease
For this study, blood and tissue samples will be collected in order to perform genetic testing to help researchers gather information about this disease and how and why it affects some patients more than others.
- Trial name
- NCT01194362
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Baylor Research Institute
Pregnancy, Heart; Complications, Valve, Prosthesis
Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Pregnancy is associated with increased risk of thrombosis among women with mechanical prosthetic heart valves.However, the best anticoagulant treatment strategies for pregnant patients with prosthetic heart valves have been…
- Trial name
- NCT02240927
- Testing
- Low Molecular Weight Heparine : Enoxaparine, Enoxaparine and 2.5 mg Warfarin, Enoxaparine and 4mg Warfarin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Morality
Valvular Aortic Stenosis Prognosis Study
Aortic stenosis is the most common valvulopathy in Western countries. Cardiac EchoDoppler is the reference method for assessment of aortic stenosis and provides prognostic elements.
- Trial name
- EPRAoV (NCT03628313)
- Testing
- Transthoracic ultrasound
- Where
- France
- Volunteers
- 3,450 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Aortic Valve Stenosis
Outcome, Recuperation and Hemodynamics in Aortic Stenosis
Indication for aortic valve replacement (AVR) in aortic stenosis (AS) is currently based on the classical triad of clinical AS symptoms, estimation of AS severity, and cardiac repercussion at rest.
- Trial name
- PROCARE-AS (NCT05272020)
- Testing
- CPET, 6MWT, QOL assessment
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Jessa Hospital
Aortic Valve Disease, Aortic Stenosis
Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement
Prospective, randomized, stratified non blinded multi-center, international, post market trial assessed in a non-inferiority study. The trial has a flexible sample size that will be determined adaptively.
- Trial name
- PERSIST-AVR (NCT02673697)
- Testing
- Perceval valve, other stented biological valve
- Where
- 47 sites in United States, Austria and 10 more
- Volunteers
- 914 people
- Sponsor
- Corcym S.r.l
Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
- Trial name
- HiRO-HCM (NCT05100420)
- Where
- 17 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Montreal Heart Institute
Velocardiofacial Syndrome, Williams Syndrome
The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
The purpose of this study is to investigate the Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to…
- Conditions
- Velocardiofacial Syndrome, Williams Syndrome, Fragile X Syndrome
- Trial name
- VCFS (NCT00768820)
- Testing
- methylphenidate, fluoxetin, risperidone
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- The Chaim Sheba Medical Center
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk
Prosthetic Valve Endocarditis
Prosthetic Valve Sweing Ring Injection by Antiboitics Can Affect the Rate of Postoperative Infective Endocarditis?
Follow-up of patients undergoing cardiac valve replacements with prosthetic valve after injection of sewing ring of prosthetic valve with aminoglycoside for prevention of infective endocarditis.
- Trial name
- NCT05455788
- Testing
- Aminoglycoside
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Block, Valve Heart Disease
Efficacy and Safety of the Sync-AV II Temporary Cardiac Pacing Catheter
This is a prospective, single-center, non-randomized open label study. The objective of this study is to evaluate the efficacy and safety of the Sync-AV II Temporary Cardiac Pacing Catheter in subjects whose elective surgical or…
- Trial name
- NCT06261788
- Testing
- Temporary pacing
- Where
- Paraguay
- Volunteers
- 30 people
- Sponsor
- Swift Sync, Inc.
Mitral Valve Insufficiency, Coronary Artery Disease
Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation
Coronary artery bypass grafting (CABG) is a procedure that people with coronary artery disease (CAD) may undergo to increase blood flow to the heart.
- Trial name
- NCT00806988
- Testing
- Mitral Valve Repair, CABG
- Where
- 27 sites in United States, Canada and 1 more
- Volunteers
- 301 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myocardial Protection, Minimally Invasive Surgery
Myocardial Protection in Minimally Invasive Mitral Valve Surgery
Perfusion strategies and aortic clamping techniques for right mini-thoracotomy mitral valve (MV) surgery have evolved over time and remarkable short- and long-term results have been re-ported.
- Conditions
- Myocardial Protection, Minimally Invasive Surgery, Mitral Valve Prolapse
- Trial name
- NCT04231903
- Testing
- Aortic clamp
- Volunteers
- 116 people
- Sponsor
- University of Turin, Italy
Minimally Invasive Mitral Valve Surgery
Minimally Invasive Mitral Valve Replacement Versus Conventional Approach: Comparison of Early Postoperative Outcomes.
The term minimally invasive mitral valve surgery has been reported (MIMVS) by American Heart Association and referred to a collection of new techniques.
- Trial name
- NCT05504109
- Testing
- mitral valve replacement through full sternotomy approach., mitral valve replacement through right mini thoracotomy approach.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
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