Clinical trials: Variability
Depression
Binaural Beat Music Combined With Rhythmic Photic Stimulation on Depression
Background: Previous studies have suggested that non-pharmacological treatments, such as binaural beat music (BBM) and rhythmic photic stimulation (RPS), may help improve depressive symptoms and enhance quality of life.
- Trial name
- NCT06540157
- Testing
- Binaural Beat Music (BBM) Combined with Rhythmic Photic Stimulation (RPS)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Type I Diabetes
Epigenetic Modifications of Diabetes Mellitus Type I
This research is being done to find out if significant changes in blood glucose cause bad outcomes in patients with diabetes.
- Trial name
- NCT01623388
- Testing
- Oral glucose tolerance test for Phase I
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Mitochondrial Oxygenation Measurement, Measurement Error
Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study)
To determine the between- and within-subject variability of the mitochondrial oxygenation measurement with the COMET device over time in healthy subjects and in hemodynamically stable subjects admitted to the intensive care unit.
- Conditions
- Mitochondrial Oxygenation Measurement, Measurement Error, Healthy
- Trial name
- NCT04626661
- Testing
- COMET measurement system
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Developmental Disability, Chronic Disease
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder…
- Conditions
- Developmental Disability, Chronic Disease, Down Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03602378
- Testing
- salivary cortisol, Holter Medilog AR12 Plus, Polar V800
- Where
- 2 sites in Croatia
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Emotional Well-being, Psychological Stress
Feasibility of a Mind-Body Intervention for Optimism
This pilot study tests whether three brief mind-body activities can be delivered remotely to midlife adults, and whether they show early signs of improving cardiovascular health, emotional well-being, and stress.
- Conditions
- Emotional Well-being, Psychological Stress, Cardiovascular Risk
- Trial name
- NCT07862478
- Testing
- Emotional Well-Being Writing, Chair-Assisted Squats, Slow-Paced Breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Penn State University
Inflammation
Anti-inflammatory Actions of Osteopathic Manipulative Treatment
This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions through activation of the…
- Trial name
- OMT_taVNS (NCT04177264)
- Testing
- Occipito-Atlantal Decompression (OA DC), Splenic Lymphatic Pump Technique (SpLPT), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Burrell College of Health Sciences
Major Depressive Disorder
Heart Rate Variability in Depression
The purpose of this study is to understand if there is a relationship between the way that emotions are regulated by the brain and the way that heart rate is regulated by the brain.
- Trial name
- NCT02525978
- Testing
- Video Task, Imaginal Task
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University
Treatment Resistant Schizophrenia, Clozapine Adverse Reaction
Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.
Clozapine is the only drug approved for Treatment Resistant Schizophrenia. However, it has been associated with many adverse drug reactions including agranulocytosis, myocarditis, sialorrhea, constipation, orthostasis…
- Conditions
- Treatment Resistant Schizophrenia, Clozapine Adverse Reaction, Heart Rate Variability, Tachycardia
- Trial name
- NCT06505668
- Testing
- Atenolol 25 mg, Ivabradine 10mg
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Depression, Couples (Persons)
Social Interaction and Compassion in Depression
The purpose of this study is to determine how a CBCT® (Cognitively Based Compassion-Training) for couples affect aspects of health and especially social interactions in depressed female patients and their romantic partners.
- Trial name
- SIDE (NCT03080025)
- Testing
- CBCT® (Cognitively Based Compassion-Training)
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Pharmacologic Action
Genetic Variability in CYP2D6 in U.S Active Duty Population
The investigator proposes to 2D6 (Cytochrome P-450 Isoenzyme 2D6) genotype and phenotype a group of active duty service members and assess the effects on primaquine metabolism.
- Trial name
- NCT02960568
- Testing
- Primaquine
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Pranayama Effect on Autonomic Nervous System, Respiration Variability Effect on Nervous System
Pranayama Practice on the Autonomic Nervous System
The proposed study design will be a randomized, cross-over trial testing different pranayama breathing interventions. Participants (N=40) will perform each of the following five interventions in a randomly assigned order: (1)…
- Trial name
- PYAMA (NCT03280589)
- Testing
- Sheetali/Sheekari Pranayama, Sitting Quietly, Deep breathing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Warm Footbath, Cardiovascular System
Temperature-dependent Changes in Cardiovascular Parameters During Warm Water Footbaths in Healthy Women
A study to explore whether different temperatures of warm water footbaths have different effects on the cardiovascular system, the autonomic nervous system and the general well-being of healthy women.
- Conditions
- Warm Footbath, Cardiovascular System, Autonomic Nervous System
- Trial name
- NCT04579497
- Testing
- 38°C warm water footbath, 40°C warm water footbath, 42°C warm water footbath
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Behavior, Social, Autonomic Imbalance
Coping Strategies and Responsiveness to a Brief Online Intervention During COVID-19 Pandemic
The present study investigates the efficacy of a brief and cost-effective video-intervention that combines bottom-up elements of deep breathing and third-wave cognitive behavioral therapy techniques (i.e., mindfulness and…
- Trial name
- NCT04382560
- Testing
- Deep Breathing training, Compassion focused intervention
- Where
- Italy
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Parma
Fluid Overload Without Edema
Fluid Administered According to PVI Versus Fluid Management in Laparoscopic Trendelenburg Surgeries
Investigating the ideal fluid management in Trendelenburg positions during lower abdominal laparoscopic surgeries in gynecological oncology and surgical oncology patients
- Trial name
- NCT06633510
- Testing
- massimo group, standart group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Cardiovascular Diseases, Prevention
Acute Effects of Beet Extract on Autonomic and Cardiovascular Recovery After Exercise
Dietary NO3 is found in high concentrations in green leafy vegetables and beets. Studies weighing the action of NO3 for ergogenic purposes have found metabolic improvement in skeletal muscle during exercise in hypoxia, lowering…
- Trial name
- NCT04094233
- Testing
- Beetroot extract
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 4 of 7)
NOTE: This is the fourth of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02919228
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Stress, Psychological Resilience
Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress
The goal of this clinical trial is to learn if diaphragmatic breathing and box breathing work to enhance resilience and manage stress in physical therapy students.
- Conditions
- Stress, Psychological Resilience, Healthy Students
- Trial name
- HRV DB BB PSS (NCT07698652)
- Testing
- Diaphramatic Breathing Training, Box Breathing Training
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Laparoscopic Surgery Simulation, Mental Workload
Impact of Preferred Music on Laparoscopic Task Performance and Mental Workload in Novice Surgeons
This single-blinded, three-arm randomized controlled trial evaluated the effects of different auditory environments on laparoscopic task performance and mental workload among novice surgeons in a simulated setting.
- Conditions
- Laparoscopic Surgery Simulation, Mental Workload, Stress, Psychomotor Performance
- Trial name
- NCT07738848
- Testing
- Behavioral: Preferred Music, White Noise, SIlent Control
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Universiti Sains Malaysia
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo