Clinical trials: Variability
Healthy Volunteer
A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers
This is a multiple part, multiple cohort study evaluating single and multiple ascending doses, relative bioavailability, food effect, and drug-drug interaction of NX-5948 in healthy volunteers.
- Trial name
- NCT06717269
- Testing
- NX-5948, Esomeprazole, Famotidine
- Where
- 2 sites in United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Nurix Therapeutics, Inc.
Endothelial Dysfunction
Effect of Different Methodologies on Variability of Brachial Artery Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery has been widely used as a non-invasive measure of endothelial function. FMD independently predicts future cardiovascular events and can be readily influenced by pharmacological…
- Trial name
- NCT01899937
- Where
- 4 sites in Italy, Netherlands
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers
A Open-label, Three-period, Partial-replicate Design Study to Evaluate the Inter- and Intrasubject Variability of the Avatrombopag To-be-marketed Formulation Administered as Single Doses of 40 mg to Healthy Subjects Receiving a Low-fat Meal
A Randomized, Open-label, Three-period, Partial-replicate Design Study to Evaluate the Inter- and Intrasubject variability of the Avatrombopag To-be-marketed Formulation Administered as Single Doses of 40 mg (all doses are…
- Trial name
- NCT01759394
- Testing
- Avatrombopag maleate 40 mg
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Acquired Brain Injury
The Effect of Auditory Stimuli on Heart Rate Variability (HRV) Among Patients With Acquired Brain Injury (ABI)
Heart Rate Variability (HRV) reflects the responsiveness of the autonomic system to an external stimuli. The aim of this system is to maintain homeostasis.The variability implies on the interaction between the sympathetic and the…
- Trial name
- NCT01454557
- Testing
- Auditory Stimuli
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Digestive System
Personal Protein Digestion Variability
This study aims to quantify the variation in postprandial AA profiles between (and within) individuals after consumption of a poorly digestible plant protein source (Lucerne) and to compare the variation in postprandial AA…
- Trial name
- DiVa (NCT05118412)
- Testing
- Lucerne protein concentrate shake, Whey protein concentrate shake
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Iodine Deficiency
Variability of Daily Iodine Intake: The Effects of Intra- and Inter-individual Variability in Iodine Nutrition Studies
Iodine status in populations is assessed using urinary iodine concentration (UIC) measured in spot urine samples. The iodine intake is classified as deficient, sufficient, or excessive iodine based on the median UIC (mUIC).
- Trial name
- VIOLET (NCT03731312)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Stress, Physiological, Stress, Psychological
Daoist Zhanzhuang and Human Flourishing
This project investigates the impact of Daoist Zhanzhuang (sometimes spelled as Chan Chuang) on human flourishing, and explores the physiological, psychological, and spiritual mechanisms.
- Conditions
- Stress, Physiological, Stress, Psychological, Inflammatory Response, Well-Being, Psychological
- Trial name
- Z-Flo (NCT06573034)
- Testing
- Daoist Zhanzhuang
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Charlotte
Healthy
Influence of Manual and Electrical Vagal Stimulation on Autonomic Activity and Other Dysautonomous Symptoms in a Healthy Population.
The objective of this clinical, longitudinal, prospective, randomised (randomised) unmasked study is to analyse whether electrical and manual vagal stimulation produces changes in heart rate variability in a healthy population…
- Trial name
- NCT07660744
- Testing
- Electrical stimulation of the vagus nerve, Manual stimulation of vagus nerve
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Escoles Universitaries Gimbernat
Stress
Psychophysiological Stress Response in Medical Students During Simulation-Based Communication Training -Study Protocol
In this study, researchers will examine key predictors of stress reactions in medical students participating in simulation-based communication training.
- Trial name
- SIMU2025 (NCT06906614)
- Testing
- Simulation-Based Communication Training
- Where
- Czechia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Healthy
Exploring the Cortical Hemodynamic Variability of Prefrontal iTBS: a Concurrent TBS/fNIRS Study
An increasing number of studies have used the intermittent theta-burst stimulation (iTBS) protocol to investigate neural plasticity non-invasively in the prefontal cortex in healthy humans and in patients with psychiatric…
- Trial name
- NCT06104462
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Gastroparesis, Functional Dyspepsia
Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at…
- Conditions
- Gastroparesis, Functional Dyspepsia, Healthy, Digestive System Disease
- Trial name
- AVNS (NCT05405842)
- Testing
- Transauricular Vagal Nerve Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Low Back Pain
The Neural Basis of Lumbosacral Proprioceptive Impairment in Recurrent Low Back Pain
Low back pain (LBP) is a well known health problem in Western society that is significantly responsible for socio-economic problems like absenteeism and disability.
- Trial name
- NCT01540617
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Subluxation
Simulated vs Genuine Manual Chiropractic Adjustments
Our primary aim with this trial is to measure participant blinding following two simulated/sham or genuine/real high velocity, low amplitude (HVLA) manual chiropractic adjustments to assess if participants are able to identify…
- Trial name
- SHA (NCT06931600)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Life University
Heart Rate Variability
Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance
The ability of smart phones, aided by wearable devices (e.g. smart watches), to collect a variety of data, including physical activity, heart rate, and other exercise metrics, may provide a unique opportunity to understand…
- Trial name
- NCT06964100
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Aging, Mobility Disability
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
- Trial name
- BRIO (NCT06940037)
- Testing
- Progressive Resistance Training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hemophilia A
Evaluation of a Standardized Protocol for Thrombin Generation Assay
This study is aims at determining the inter laboratory variation when using the thrombin generation assay calibrated automated thrombogram (TGA CAT). It is thus, not a clinical trial in its usual meaning.
- Trial name
- NCT03313531
- Testing
- Thrombin Generation Assay, Treatment with recombinant coagulation factor
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Lund University
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight , Obesity
Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study
This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or…
- Trial name
- NCT07849439
- Testing
- Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Heavy Drinking, Harmful; Use, Alcohol
A PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults
Heavy alcohol use among young adults is a significant public health problem. Advances in technology may offer an innovative solution.
- Trial name
- NCT05090995
- Testing
- Behavioral Self-Management and Feedback, Behavioral Self-Management
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Heart Failure, Autonomic Nervous System Imbalance
Evaluation of the Six Minute Walk Test and Other Instruments in Heart Failure
The purpose of this study is to assess functional capacity, quality of life and functioning of the autonomic nervous system in heart failure patients on beta-blocker treatment.
- Conditions
- Heart Failure, Autonomic Nervous System Imbalance, Heart Rate and Rhythm Disorders, Quality of Life
- Trial name
- NCT01736137
- Testing
- Six minute walk test
- Where
- Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia