Clinical trials: Variability
Cardiovascular Diseases, Hypertension
The Galway Sea Swimmers Study
Cardiovascular disease (CVD) is the leading cause of death worldwide. Hypertension is a well-established risk factor for the development of CVD.
- Trial name
- GS3 (NCT04290637)
- Testing
- Cold-water sea swimming, No cold-water sea swimming
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Healthy
Exploring the Cortical Hemodynamic Variability of Four Weeks iTBS on a Healthy Participant: a Case Study
This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. The investigators will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20…
- Trial name
- NCT05427565
- Testing
- caffeine, Experimental time
- Where
- Hong Kong
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Low Back Pain
Heart Rate Variability Modulation Following a Manipulation in Pain Free Patients Versus Patients in Pain
Background The purpose of this study was to examine the heart rate variability (HRV) in the presence or the absence of pain in the lower back (L5), while receiving chiropractic care.
- Trial name
- NCT00740558
- Testing
- Activator methods technique, Traditional chiropractic adjustment
- Where
- 2 sites in Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Gut Microbiome, Buffer
PRObing The Efficacy of Commercial Stage Storage Buffers and Evaluating Gut Metaproteome Variability Between Individuals
The study aims to assess the effectiveness of various commercial and non-hazardous buffers for the storage of human gut fecal samples over time.
- Conditions
- Gut Microbiome, Buffer, Methodology Study, Fecal Microbiota
- Trial name
- PROTEGI (NCT06423508)
- Where
- Austria
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Physiology of Manipulation / Mobilization in Healthy Adults
A Study of the Effects of Mid-Thoracic Spinal Manipulation and Spinal Mobilization on Heart Rate Variability
Spinal mobilization and spinal manipulation are common techniques utilized in the field of physical therapy. Despite their common utility, little is known about the physiological mechanisms underlying the changes experienced…
- Trial name
- NCT02380599
- Testing
- Spinal Manipulation, Spinal Mobilization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mount St. Mary's College, Los Angeles, CA
Healthy Volunteers
Heart Rate Variability During Auricular Acupressure at Zero Point on the Left Ear in Healthy Volunteers
Heart rate variability (HRV) is used to noninvasively assess the activity of the autonomic nervous system, in particular, its parts help to evaluate the cardiac sympathetic and parasympathetic activities.
- Trial name
- NCT05586698
- Testing
- Auricular acupressure
- Where
- Vietnam
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Bui Pham Minh Man
Hypertension
L-citrulline Supplementation & Cold Exposure
Cardiovascular disease (CVD) is considered the primary cause of death in the developed world. Large scale epidemiological studies indicate that prevalence of hypertension along with adverse cardiovascular events peak during the…
- Trial name
- NCT01462591
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Stress (Psychology), Anxiety
HRVB for Stress and Anxiety During Dentistry Students' Clinical Transition
The goal of this clinical trial is to learn if Heart Rate Variability Biofeedback (HRVB) can reduce stress and anxiety in dentistry students during the transition from pre-clinical training to clinical practice.
- Conditions
- Stress (Psychology), Anxiety, Psychological Distress
- Trial name
- HRVB-MIMD (NCT07415915)
- Testing
- Heart Rate Variability Biofeedback (HRVB) Training
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Chronic Obstructive Pulmonary Disease (COPD)
Force Control in Chronic Obstructive Pulmonary Disease
Maximal muscle strength is one of the most commonly assessed neuromuscular parameters in people with COPD due to its accessibility and relevance for prescribing an appropriate workload for resistance training.
- Trial name
- NEUROTIGUE F (NCT06871670)
- Testing
- Submaximal isometric contractions of knee extensors
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
HIV
Dose-Proportionality and Intra-Individual Variability of Intracellular TFV-DP and FTC-TP in Healthy Volunteers
Describe the dose-proportionality and intra-individual variability of tenofovir diphosphate (TFV-DP) and emtricitabine triphosphate (FTC-TP) at steady-state in healthy human participants taking Truvada® (FTC 200mg/TDF 300 mg)…
- Trial name
- HPTN066 (NCT01276600)
- Testing
- Emtricitabine/tenofovir
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
Alzheimer Disease
Draw-10: A Weekly Blood Draw Study to Understand the Biological Variability of Plasma pTau-217
This is an observational study that will serially collect 10 plasma samples over the course of 9 weeks from the same individuals to assess fluctuations in blood biomarker results.
- Trial name
- Draw-10 (NCT06742944)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Banner Health
HIV
Concentrations of Raltegravir in the Semen of HIV-Infected Men
The objective of this study is to determine if concentrations of raltegravir in semen exceed the 50% and 95% inhibitory concentrations of HIV during the dose interval.
- Trial name
- NCT01045265
- Testing
- Seminal plasma pharmacokinetics
- Where
- 2 sites in Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Canadian Immunodeficiency Research Collaborative
Vestibular Schwannoma, Inner Ear Disease
Vestibular Precision: Physiology & Pathophysiology
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors.
- Conditions
- Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2
- Trial name
- NCT04890132
- Testing
- VOR precision training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Healthy
Effects of a Novel Supplement on Glycemic Variability Measured by Continuous Glucose Monitoring
This is a two-cohort, crossover pilot study to determine interstitial glucose levels coincident with the consumption of a novel carbohydrate blocking supplement.
- Trial name
- NCT05832463
- Testing
- Carbohydrate blocking supplement (CBS)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Depressive Disorder, Major
Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?
The purpose of this study is to investigate the effects of a multispecies probiotic on the function of the vagal nerve in patients with major depression and healthy participants in a single-center, randomized, placebo-controlled…
- Trial name
- ProBIO-HRV (NCT04772664)
- Testing
- Multispecies-Probiotic
- Where
- Austria
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Healthy
Effects of Dual-task Exercises on Gait Parameters and Cognitive Function in Elderly Women: A Randomized Controlled Trial
The training of a secondary task while walking, whether it is reasoning activities, memory or motor tasks, may enhance automation, walking performance, and postural control and, thus, minimize the risk of falls influenced by the…
- Trial name
- NCT02185157
- Testing
- dual -task exercises, Aerobic training
- Where
- Brazil
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy Subjects
A Study to Examine the Absorption of GSK561679 in Healthy Male Volunteers
This study will be conducted in healthy volunteers to investigate the absorption of GSK561679 using Gamma Scintigraphy, PillCam™ SB capsule and the acoustic vest.
- Trial name
- NCT00539136
- Testing
- GSK561679 tablet or solution
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes
The Impact of Glucotoxicity on Gastric Emptying in Chinese Patients With Newly Diagnosed Type 2 Diabetes
Gastric emptying is now recognized as a major determinant of the blood glucose response to carbohydrate in both health and type 2 diabetes (T2D).
- Trial name
- NCT05284344
- Testing
- Anti-Diabetics
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Chronic Instability of Joint
The Influence of Dual Task and Gait Speed on Gait Variability in Patients With Chronic Ankle Instability
Case-control study to evaluate gait parameters during different conditions between patients who suffer from chronic ankle instability and healthy individuals.
- Trial name
- NCT02745834
- Testing
- Gait analysis
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force