Clinical trials: Varicose Vein Disease
Chronic Venous Leg Ulcers
Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers
The primary objective is to evaluate the clinical benefit of CureXcell® as adjunct to Standard of Care in the treatment of Chronic Venous Leg Ulcers.
- Trial name
- NCT02130310
- Testing
- CureXcell®
- Where
- 28 sites in United States
- Volunteers
- 252 people
- Sponsor
- Macrocure Ltd.
Venous Leg Ulcer
Differential Effects of Bacteria Colonising Venous Leg Ulcers on Pain and Healing Rates
This Study aims to identify whether venous leg ulcers which are colonised by Pseudomonas Aeruginosa cause more pain than those which are not and if this bacteria affects healing time.
- Trial name
- NCT04249661
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- University Hospital of Limerick
Varicose Veins, Venous Reflux
Pelvic Embolisation to Reduce Recurrent Varicose Veins - Primary
The aim of this study is to identify whether the treatment of pelvic venous reflux (pelvic coil embolisaton) in females with leg varicose veins, who have a proven contribution to their leg varicose veins from pelvic reflux, have…
- Trial name
- NCT01901731
- Testing
- transjugular coil embolisation of pelvic veins, endovenous treatment of leg varicose veins
- Where
- 2 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- The Whiteley Clinic
Vascular Disease，Peripheral, Venous Insufficiency of Leg
Observation of Pain During the Treatment of Great Saphenous Vein Using Microwave Ablation， and Analysis of Related Factors
Objective: This study is a single-center prospective observational research that recorded patients' pain scores at four time points during surgery (puncture and catheter insertion, swelling fluid injection, microwave generator…
- Conditions
- Vascular Disease，Peripheral, Venous Insufficiency of Leg, Varicose Veins of Lower Limb
- Trial name
- NCT06693245
- Testing
- VAS scores of the puncture
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Varicose Veins
Hypnoanalgesia in Surgical and Endovenous Treatment of Varicosis
Endoveinous treatment of saphenous varicoses and phlebectomia of tributary veins are commonly performed under local anesthesia. Hypnoanalgesia might reduce perinterventional pain.
- Trial name
- NCT03601572
- Testing
- No intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Varicose Veins, Venous Reflux
High Intensity Focused Ultrasound in PAtients With Varicose Veins in Singapore
The aim of the study is to evaluate the efficacy of non-invasive echotherapy for the treatment of varicose veins, within local population, using the Sonovein® device.
- Conditions
- Varicose Veins, Venous Reflux, Chronic Venous Insufficiency
- Trial name
- VESPA (NCT04339088)
- Testing
- Questionnaires
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- Singapore General Hospital
Venous Hypertension Ulcers, Venous Stasis Ulcer
Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
The goal of this study is to test MUSTCOOL, a home-based self-monitoring and self-management ulcer prevention intervention for patients with newly healed chronic venous leg and diabetic foot ulcers.
- Conditions
- Venous Hypertension Ulcers, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
- Trial name
- MUSTCOOL (NCT02626156)
- Testing
- Cooling gel pack, Cooling cotton pack
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Venous Stasis Ulcers
Provant Therapy of Venous Stasis Ulcer Trial
This pilot study hypothesizes that use of the Regenesis Provant Wound Therapy System (a radiofrequency device) twice daily over venous stasis ulcers (wounds thought to occur due to improper functioning of valves in the veins…
- Trial name
- NCT01050023
- Testing
- Provant Device (Wound Therapy System), Provant Device - Inactive
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Southern California Institute for Research and Education
Compensated Advanced Chronic Liver Disease, Variceal Hemorrhage
Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004)
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices, esophagogastroduodenoscopy (EGD) should be performed.
- Trial name
- NCT04546360
- Testing
- Esophagogasrtoduodendoscopy, spleen stiffness measurement and liver stiffness measurement.
- Where
- 6 sites in China
- Volunteers
- 381 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral)
Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation
Endothermal heat-induced thrombosis (EHIT) is a thrombotic complication specific to endovenous thermal ablation of the great saphenous vein (GSV), for which no prophylactic regimen is standardized.
- Conditions
- Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
- Trial name
- NCT07699796
- Testing
- Apixaban, Rivaroxaban
- Where
- United States
- Volunteers
- 564 people
- Sponsor
- Heart, Artery, and Vein Center of Fresno
Wound Care, Pressure Ulcer
Direct Application of Integra Bilayer Matrices on Bare Calvarium Without Preliminary Burring
This study is to determine if large, full thickness scalp wounds with exposed calvarium resulting from acutely created extirpative defects can be reliably and durably resurfaced with IDRT without burring or fenestration as a…
- Conditions
- Wound Care, Pressure Ulcer, Venous Ulcer, Surgical Wound
- Trial name
- NCT05311124
- Testing
- Integra Dermal Regeneration template (IDRT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Joshua Choo
Venous Leg Ulcer
Impact of Venotrain UlcerteC Venous Compression Device in the Treatment of Venous Ulcers in Daily Practice
The cornerstone of the management of venous leg or predominantly venous leg ulcers with IPS> 0.8 is venous compression as recommended by the HAS in June 2006.
- Trial name
- INVICTUS (NCT03736941)
- Testing
- Patients with venous leg
- Where
- 2 sites in France
- Volunteers
- 129 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Wounds, Wound of Skin
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up.
- Conditions
- Wounds, Wound of Skin, Wound Leg, Wound; Foot
- Trial name
- NCT05588583
- Testing
- Mepilex Up
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Molnlycke Health Care AB
VARICOSE VEINS
Safety And Efficacy Study Of Topic Mucopolysaccharide Polysulfate Cream In The Superficial Varicose Veins Treatment
Evaluate the safety, tolerability and effectiveness of mucopolysaccharide polysulfate cream in the treatment of superficial varicose veins
- Trial name
- NCT01426035
- Testing
- TOPIC MUCOPOLYSACCHARIDE POLYSULFATE CREAM 5MG/G
- Where
- Brazil
- Sponsor
- EMS
Venous Leg Ulcer (VLU), Venous Hypertension Ulcers
Effect of Photobiomodulation on Healing of Venous Leg Ulcers
Venous leg ulcers are a significant public health problem because of their prolonged duration, high recurrence rates, and economic, social, and quality-of-life effects.
- Conditions
- Venous Leg Ulcer (VLU), Venous Hypertension Ulcers, Chronic Venous Insufficiency, Chronic Venous Disease
- Trial name
- NCT07123285
- Testing
- Photobiomodulation Therapy, Compression Therapy
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- University of Nove de Julho
Varicose Vein, Postoperative Pain
Propofol Versus Volatile Anesthesia in Post Operative Pain Management
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.
- Trial name
- NCT00712517
- Testing
- propofol, sevoflurane
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Patient Empowerment, Venous Leg Ulcer
The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction
Background and rationale: Venous leg ulcers (VLU) are slow healing wounds with a recurrence rate of 70% and a 60% risk of becoming chronic. The estimated VLU prevalence in the general population is 3%.
- Conditions
- Patient Empowerment, Venous Leg Ulcer, Interdisciplinary Communication
- Trial name
- vened (NCT04019340)
- Testing
- Education
- Where
- 3 sites in Switzerland
- Volunteers
- 87 people
- Sponsor
- School of Health Sciences Geneva
Venous Leg Ulcers
A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers
Assess the influence of HP802-247 on biochemical and cellular markers of inflammation in chronic venous leg ulcers
- Trial name
- MOA 034 (NCT02154087)
- Testing
- HP802-247
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Healthpoint
Diabetic Foot Ulcer, Venous Leg Ulcer
PLASOMA Ultimate Safety & Efficacy Study
The purpose of the PULSE study are the followingL A.To perform post market clinical follow up (PMCF) on safety and efficacy: 1. Safety: To confirm transient short-terms side effects and verify long-term/outstanding risks. 2.
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer, Burn Wound
- Trial name
- PULSE (NCT04828304)
- Testing
- PLASOMA
- Where
- 6 sites in Netherlands
- Volunteers
- 101 people
- Sponsor
- Plasmacure
Venous Leg Ulcers
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Venous Leg Ulcers
To assess the efficacy of the PRP Concepts Fibrin Bio-Matrix and compare its performance with usual and customary practice for the treatment of chronic non-healing venous leg ulcers (VLU).
- Trial name
- NCT02312518
- Testing
- PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- PRP Concepts, LLC