Clinical trials: Vascular Aging
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Persistent COVID Condition
Predictors of Long-Term Evolution in Long COVID; 4-Year Follow-Up. (BioICOPER Follow-up Study)
Long COVID (persistent COVID) represents a major global health challenge due to its high prevalence (approximately 7%), significant impact on quality of life, and socioeconomic burden.
- Trial name
- NCT07295483
- Testing
- BioICOPER Long COVID Cohort
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Estrogen, Premenopause
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
- Trial name
- V-RISES (NCT06745466)
- Testing
- ganirelix acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Stroke, Aging Problems
Innovative Models in the Rehabilitation of the Elderly With Stroke Through Technological Innovation
The final goal of the present study is to propose a new approach and an innovative therapeutic plan in the post-stroke rehabilitation of elderly patients, focused on the use of robotic device, in order to obtain the beneficial…
- Conditions
- Stroke, Aging Problems, Innovative Rehabilitation Treatment Based on Robotics
- Trial name
- NCT04087083
- Testing
- Technological intervention arm, Control arm
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Healthy Aging, Aging
An Evaluation of Folic Acid to Improve Endothelial Sensitivity to Shear Stress in Seniors
The purpose of this study is to evaluate if folic acid improves endothelial sensitivity to shear stress in post-menopausal women.
- Conditions
- Healthy Aging, Aging, Menopause
- Trial name
- NCT04016090
- Testing
- Folic Acid
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Vascular Risk, Aging Disorder
Aging of the Vascular Wall
Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs.
- Trial name
- VITAL (NCT07122427)
- Testing
- Graft collection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Multiple Myeloma, Amyloidosis
Cancer and Aging Resilience Evaluation in Older Adults With Hematologic Malignancies: The CARE-Heme Registry
The primary purpose of this protocol is to create a registry of older (≥50 years old) patients with Hematologic Malignancies. Our main objectives include: To understand the prevalence of frailty and geriatric impairments among…
- Conditions
- Multiple Myeloma, Amyloidosis, Plasma Cell Leukemia
- Trial name
- CARE-Heme (NCT05556928)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy Aging, Healthy
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Foods rich in certain (poly)phenols, particularly flavonoids, such as berries and cocoa, have been shown to improve measures of vascular function as well as cognitive performance in human intervention studies.
- Trial name
- BluFlow (NCT04084457)
- Testing
- Wild Blueberry powder
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- King's College London
MCI, Alzheimer Disease
Cognitive Impairment in Ageing People
Mild cognitive impairment (MCI) and neurocognitive disorder such as Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly.
- Conditions
- MCI, Alzheimer Disease, VAD - Vascular Dementia, Cognitive Impairment
- Trial name
- NCT04360200
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yamei Tang
Stroke
Manual Dexterity Control After Cerebellar Stimulation
This study will assess the putative advantages of cerebellar stimulation on motor learning abilities of stroke patients. In order to have a control group to refer to, the effect of cerebellar stimulation on healthy young and old…
- Trial name
- MADECCS (NCT03092570)
- Testing
- With stimulation, No stimulation
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Vascular Endothelium, Microvascular Circulation
Healthy Age-dependent Reference Values for Microvascular Structure and Function
The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes.
- Conditions
- Vascular Endothelium, Microvascular Circulation, Arterial Stiffness, Healthy Ageing
- Trial name
- NCT04897191
- Testing
- Age
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Dementia, Mixed, Dementia, Vascular
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
- Conditions
- Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline
- Trial name
- STAREE-Mind (NCT05586750)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 2 sites in Australia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Monash University
Aphasia, Stroke
ReadMap: Reading in Stroke Alexia and Typical Aging
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for…
- Conditions
- Aphasia, Stroke, Alexia
- Trial name
- ReadMap (NCT06700005)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Aging, Menopause
Gonadal Hormone, Gonadotropin and Cardiovascular Events
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated.
- Trial name
- NCT02810821
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Intermittent Fasting, Aging
The Effect of Intermittent Fasting on Brain Health
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT06019195
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Stroke
Power Exercise for Stroke Recovery: The POWER Pilot Trial (POWER-P)
Weakness is one of the most common consequences of stroke. For the over 750,000 Canadians living with stroke, many daily activities like standing from a chair, walking and balance not only require strength but often efforts in…
- Trial name
- POWER-P (NCT06780995)
- Testing
- Power Exercise for Stroke Recovery (POWER), Strength Training Engaging Guidelines to Enhance Total Health (STRENGTH)
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Glucose Intolerance, Aortic Stiffness
Healthy Aging Through Functional Food
The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.
- Conditions
- Glucose Intolerance, Aortic Stiffness, Vasodilation
- Trial name
- HATFF (NCT02095873)
- Testing
- Glyoxalase 1 (Glo1) inducer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Physical Inactivity, Aging
The Effects of 8 Weeks Post Exercise Hot Water Immersion on Vascular and Cardiometabolic Health in Physically Inactive Middle-aged Adults
This research project aims to determine whether post exercise hot water immersion can improve vascular and cardiometabolic health to a greater extent than post exercise thermoneutral water immersion in healthy middle-aged adults.
- Trial name
- NCT05409404
- Testing
- Aerobic exercise + hot water immersion, Aerobic exercise + thermoneutral water immersion
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Coventry University