Clinical trials: Vascular Conditions
Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome
The purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (RBC) transfusion strategy compared to a restrictive strategy (usual care)…
- Trial name
- SAHaRA Pilot (NCT02483351)
- Testing
- Liberal Red Blood Cell Transfusion Strategy, Restrictive Red Blood Cell Transfusion Strategy
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Ischemic Stroke, Atrial Fibrillation
Registration Study of Acute Ischemic Stroke/Transient Ischemic Attack (TIA) With Atrial Fibrillation
Patient Registration Study of Acute Ischemic Stroke/transient ischemic attack(TIA) With Atrial Fibrillation (AISWAF) is a single-center prospective, consecutively, observational study, was conducted in patients with acute…
- Trial name
- AISWAF (NCT04080830)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Melatonin, Myocardial Infarction
Plasma Melatonin AND Mortality After Acute Myocardial Infarction
Pre-clinical and clinical studies have demonstrated that melatonin has cardio-protection effects. Melatonin has anti-inflammatory, antioxidant, antihypertensive, antithrombotic and antilipaemic properties, which plays important…
- Trial name
- NCT03230630
- Testing
- plasma melatonin levels
- Volunteers
- 732 people
- Sponsor
- Chinese PLA General Hospital
Arterio-venous Fistula, Intracranial Arteriovenous Malformations
PHIL® Embolic System Pediatric IDE
The purpose of this study is to collect information about how the PHIL® Embolic System works in the treatment of intracranial dural arteriovenous fistulas.
- Trial name
- NCT03731000
- Testing
- PHIL® device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Alejandro Berenstein
Acute Coronary Syndrome, ST Elevated Myocardial Infarction
the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry
The global burden and threat of non-communicable diseases (NCDs) have become a major health challenge that undermines social and economic development throughout the world.
- Conditions
- Acute Coronary Syndrome, ST Elevated Myocardial Infarction, Non ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- PERFUSION (NCT04887571)
- Testing
- No Intervention - Observational Registry
- Where
- 4 sites in South Africa
- Volunteers
- 870 people
- Sponsor
- University of Cape Town
Traumatic Brain Injury, Subarachnoid Hemorrhage
Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients
Neurocritical ill patients are frequently transfused. Red blood cell transfusion (RBCT) in these patients has been associated with deleterious effects, including higher rates of nosocomial infections, multi-organ failure, and…
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT00566709
- Testing
- Red blood cells transfusion
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Intracerebral Hemorrhage, Targeted Temperature Management
Targeted Temperature Management Via Bladder Monitoring in ICH
The goal of this clinical trial is to learn whether a bladder temperature monitoring-guided targeted temperature management (TTM) strategy improves functional recovery in patients with severe intracerebral hemorrhage, compared to…
- Trial name
- BTTM-ICH (NCT07302009)
- Testing
- Bladder Temperature Monitoring, Standard Temperature Monitoring Group
- Where
- China
- Volunteers
- 318 people
- Sponsor
- Yanyan Gong
Angina Pectoris, Coronary Heart Disease
A Study to Assess the Safety, Tolerability, and Effects of MK-0974 (Telcagepant) on Exercise Tolerance in Patients With Stable Angina (MK-0974-014)
This study will assess the safety of telcagepant in coronary artery disease (CAD) participants with stable angina during exercise treadmill testing and evaluate whether calcitonin gene-related peptide (CGRP) receptor antagonism…
- Conditions
- Angina Pectoris, Coronary Heart Disease, Calcitonin Gene-related Peptide Receptor
- Trial name
- NCT01294709
- Testing
- telcagepant
- Volunteers
- 64 people
- Sponsor
- Merck Sharp & Dohme LLC
Stroke Ischemic
Paired Associative Stimulation (PAS) for Stroke Rehabilitation
Paired associative stimulation (PAS) delivered with multi-channel deep transcranial magnetic stimulation (dTMS) may enhance motor recovery in patients with first-ever ischemic stroke.
- Trial name
- PAS-Stroke (NCT07691099)
- Testing
- A multi-channel device with deep TMS coil (Brainsway Ltd., Jerusalem, Israel)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Obesity, Vitamin D3 Deficiency
Vitamins D and K Effects on Vascular Function in Obese Adults.
A prospective, randomized, placebo-controlled, double-blind study that aims to evaluate the effects of combined vitamin D3 and K2-MK7 supplementation on vascular function, sympathetic tone, metabolic biomarkers and inflammatory…
- Trial name
- NCT05689632
- Testing
- Vitamin D3 + K2-MK7, Vitamin D3
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Coronary Artery Disease, Congestive Heart Failure
A Collaborative Care Program to Improve Depression Treatment in Cardiac Patients
Depression in cardiac patients is common, persistent, and deadly. However, the vast majority of cardiac patients with depression go unrecognized and untreated, despite the existence of treatments that clearly improve depressive…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Arrhythmia, Depression
- Trial name
- NCT00847132
- Testing
- Collaborative Care Treatment, Usual Care Treatment
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Massachusetts General Hospital
Thromboembolism, Cardiac Event
Influence of Cardiac Implantable Electronic Devices on the Hemostatic System
The hemostasis system is one of the many biological systems of the human body, designed to preserve the liquid state of blood and prevent its loss during vascular injuries.
- Conditions
- Thromboembolism, Cardiac Event, Hemostatic Disorder
- Trial name
- NCT04499612
- Testing
- Cardiac implantable electronic device implantation., Cardiac implantable electronic device replace., Duplex ultrasound.
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Ryazan State Medical University
Unstable Angina
Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris
The purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite in patients who received ticagrelor followed with methoxyflurane versus ticagrelor followed…
- Trial name
- METHANE (NCT04442919)
- Testing
- Ticagrelor followed with Methoxyflurane, Ticagrelor followed with Morphine, Ticagrelor alone
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Cardiovascular Diseases, Coronary Disease
Coronary Artery Risk Development in Young Adults
To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Hypertension, Heart Diseases
- Trial name
- CARDIA (NCT00005130)
- Volunteers
- 5,115 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Leukemia
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cell transplant.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00716911
- Testing
- ganciclovir, polymerase chain reaction, flow cytometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Stroke, Stroke Sequelae
Functional Characterisation of Post-stroke Fatigue
Post-stroke fatigue is highly prevalent and disabling. However, its causes and consequences in the chronic phase are not fully understood.
- Trial name
- PSF-SAG (NCT04277234)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Relapsed or Refractory Multiple Myeloma, Patients With BRAFV600 E or BRAFV600K Mutation
BRAF/MEK Inhibition in Relapsed/Refractory Multiple Myeloma (BIRMA)
Trial for patients with refractory multiple myeloma after failure of at least two treatment regimens and with BRAFV600E/K Mutation to evaluate the efficacy of the kinase inhibitors Encorafenib (LGX818 in) combination with…
- Trial name
- GMMG-BIRMA (NCT02834364)
- Testing
- Encorafenib, Binimetinib
- Where
- 7 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University of Heidelberg Medical Center
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Myocardial Infarction
Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
The broad objective is to advance our understanding of both in vivo anatomical and functional changes that are present in the coronary arteries in women who have an acute coronary syndrome.
- Trial name
- NCT00587002
- Testing
- IVUS
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
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