Clinical trials: Vascular Disease Risk
Type2 Diabetes, Atherosclerosis
Coronary Artery Plaque Burden and Morphology in Type 2 Diabetes Mellitus.
Unstable plaque, the primary cause of myocardial infarction, is characterized by distinct a morphology including positive remodeling (PR), low attenuated plaque (LAP), napkin ring sign (NRS), and spotty calcifications (SC) The…
- Conditions
- Type2 Diabetes, Atherosclerosis, Plaque, Atherosclerotic, Plaque Vulnerability
- Trial name
- CARPEDIEM (NCT03016910)
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Svendborg Hospital
Stroke, Ischemic Attack, Transient
Platelet Reactivity in Acute Non-disabling Cerebrovascular Events
Ticagrelor is a reversible and direct-acting oral antagonist of the P2Y12 (Purinergic receptor P2Y, G-protein coupled, 12) receptor for adenosine diphosphate, which provides faster, greater, and more consistent P2Y12 inhibition…
- Trial name
- PRINCE (NCT02506140)
- Testing
- Ticagrelor and Acetylsalicylic acid, Clopidogrel and Acetylsalicylic acid
- Where
- 25 sites in China
- Volunteers
- 675 people
- Sponsor
- Beijing Tiantan Hospital
Hypertension
Real-World Validation for Less-Disturbing Ambulatory Blood Pressure Monitoring (ABPM) in Malaysia Using Huawei Wearables
Background: Ambulatory Blood Pressure Monitoring (ABPM) is the gold standard for diagnosing high blood pressure (hypertension) because it tracks blood pressure continuously across day and night.
- Trial name
- Huawei-SunU2 (NCT07790978)
- Where
- Malaysia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sunway University
Myocardial Injury
Prospective Trial: Acute Myocardial Injury After Radical Prostatectomy
This prospective observational study investigates the incidence of acute myocardial injury after radical prostatectomy for prostate cancer.
- Trial name
- NCT06273735
- Testing
- Pre- and postoperative determination of troponin as part of the study and 24-month FU survey
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Martini-Klinik am UKE GmbH
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Peripheral Artery Disease
REGistry of Long-term AnTithrombotic TherApy-1
To assess the rates of ischemic and hemorrhagic complications of long-term antithrombotic therapy in patients with chronic coronary syndromes
- Trial name
- REGATTA-1 (NCT04347200)
- Testing
- Antiplatelet Drug
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Vascular Thrombosis
Is Red Blood Cell Transfusion a Risk Factor for Vascular Pedicle Thrombosis? The Study Case of a Latin American Cohort
The present cohort was performed between January of 2014 and December of 2019. It included 302 free flaps conducted between January 2006 and December 2019 in the Hospital de San José and Hospital Infantil Universitario de San…
- Trial name
- RBCT (NCT04860544)
- Testing
- RED BLOOD CELLS TRANFUSION
- Volunteers
- 302 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Panic Disorder, Generalized Anxiety Disorder
Physical and Psychological Health Trajectories in the Context of Coronary Heart Disease
The primary aim of this study is to establish how frequently patients with coronary artery disease present or develop two anxiety disorders (panic disorder and generalized anxiety disorder) in the two years following a medical…
- Conditions
- Panic Disorder, Generalized Anxiety Disorder, Coronary Artery Disease, Anxiety Disorders
- Trial name
- NCT04433832
- Where
- Canada
- Volunteers
- 3,610 people
- Sponsor
- Laval University
Pulmonary Embolism
Prognostic Value of Heart-type Fatty Acid-Binding Protein (h-FABP) in Acute Pulmonary Embolism
The patients presenting with acute pulmonary embolism and right ventricular dysfunction are at high risk for life-threatening events and must be identified in the emergency department for adequate care and hospital admission.
- Trial name
- NCT01326507
- Testing
- Dosage de l'h-FABP
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Toulouse
Maternal Health, Infant Health
Stress Reactivity and Mother-Infant Cardiovascular Disease Risk
Prenatal Mindfulness training (MT) shows promise as a preventive intervention against hypertensive disorders of pregnancy (HDP) and may reduce risk for offspring cardiovascular disease (CVD).
- Conditions
- Maternal Health, Infant Health, Hypertension, Behavioral Medicine
- Trial name
- NCT06805799
- Testing
- Follow up to Mindfulness RCT using a Still Face Paradigm
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lifespan
Coronary Heart Disease, Cardiovascular Risk Factor
Individual Variability of Coronary Heart Disease Risk Markers and Sleep Responses to Exercise
The aim of this study is to examine the reproducibility of postprandial coronary heart disease (CHD) risk marker and sleep responses to acute exercise bouts and to quantify the magnitude of individual variability in responses…
- Conditions
- Coronary Heart Disease, Cardiovascular Risk Factor, Arterial Stiffness, Blood Pressure
- Trial name
- NCT05022498
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Chest Pain, Angina
Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain
The purpose of this study is to determine whether stress echocardiography or computed tomography (CT) of the heart is better at diagnosing emergency room chest pain patients to select appropriate candidates for hospitalization…
- Conditions
- Chest Pain, Angina, Angina Pectoris, Coronary Artery Disease
- Trial name
- NCT01384448
- Testing
- Stress Echocardiography, Coronary CT Angiography
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Hypertension
Renal Denervation for Resistant Hypertension
This is a study investigating the effectiveness of renal denervation in lowering blood pressure in people whose blood pressure is not adequately controlled despite treatment with 3 or more blood pressure lowering drugs.
- Trial name
- RDNP-2012-01 (NCT01865240)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Baker Heart and Diabetes Institute
Diabetes, Hypertension
Combined Behavioral and Pharmacological Intervention for Cardiovascular Risk Reduction in Diabetic Patients
The purpose of this research is to study whether a multidisciplinary education in Diabetes and intervention for cardiac risk reduction in a group setting to modify patient behavior and adjust medications can achieve diabetes…
- Conditions
- Diabetes, Hypertension, Dyslipidemia, Coronary Arteriosclerosis
- Trial name
- NCT00357955
- Testing
- Behavioral counseling and peer support, Interactive Education, Role modeling
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Providence VA Medical Center
Diabetes Mellitus, Type 2, Diabetes Complications
Arterial Stiffness and Complication Risk in Type 2 Diabetes
Background The prevalence and incidence of type 2 diabetes is increasing globally. A common complication of diabetes is the disease of the blood vessels, vascular diseases, which can cause disorders like myocardial infarction…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Complications, Diabetic Angiopathies, Diabetic Nephropathies
- Trial name
- NCT02001532
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease
Non-contrast Cardiac CT as a Risk Stratification Tool in Patients With Non-cardiac Chest Pain
Background: Only around 20% of all patients seen in hospital with suspected Acute Coronary Syndrome will have Acute Myocardial Infarction.
- Trial name
- NCT02422316
- Testing
- Non-contrast Cardiac CT scan
- Where
- Denmark
- Volunteers
- 248 people
- Sponsor
- University of Southern Denmark
Acute Stroke, Transient Ischemic Attack
Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis
Large-artery stenosis plays an important role in the occurrence of ischemic stroke. The primary purpose of this study is to evaluate the efficacy and safety of intensive antiplatelet therapy versus standard antiplatelet therapy…
- Trial name
- INSPIRES (NCT03635749)
- Testing
- Intensive antiplatelet, Standard antiplatelet, Immediate high-intensity statin
- Where
- 113 sites in China
- Volunteers
- 6,100 people
- Sponsor
- Beijing Tiantan Hospital
Heart Diseases
Identifying Genes That May Increase the Risk for Heart Disease in African Americans
Heart disease and stroke disproportionately affect African Americans in the United States. These conditions are likely caused by both environmental and genetic factors.
- Trial name
- NCT00344136
- Where
- United States
- Volunteers
- 5,302 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vascular Diseases
Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis
The purpose of the study is to determine whether a p38 kinase inhibitor reduces inflammation in atherosclerotic plaque
- Trial name
- NCT00570752
- Testing
- BMS-582949, Atorvastatin, Statin
- Where
- 17 sites in United States
- Volunteers
- 72 people
- Sponsor
- Bristol-Myers Squibb
Cerebral Small Vessel Diseases, Stroke
Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease
Cerebral small Vessel Disease (cSVD), characterized by an alteration of the structure and function of small penetrating brain arteries, is highly prevalent in older persons from the general population and represents a leading…
- Conditions
- Cerebral Small Vessel Diseases, Stroke, Dementia
- Trial name
- SHIVA (NCT05306834)
- Testing
- Retinal Imaging, Blood sample, Evaluation of cardiovascular risks
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease, Percutaneous Coronary Intervention
Evaluation of Novel Risk Factors and Clinical Outcomes of Acute Myocardial Infarction
The aim of this study is to investigate the potential novel risk factors for acute myocardial infarction. Predictors of poor outcomes will be also evaluated.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Myocardial Infarction
- Trial name
- NCT02641184
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Zhejiang Provincial People's Hospital
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