Clinical trials: Vascular Disease Risk
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
Patients with a non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are currently transported and admitted to the nearest emergency department (ED) for risk stratification, diagnostic workup, and treatment.
- Trial name
- NCT06051110
- Testing
- Combined risk score, Usual care, point-of-care troponin
- Where
- Netherlands
- Volunteers
- 5,239 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Essential Hypertension, Metabolic Cardiovascular Syndrome
Technological Innovation in the Virtual Assistance of Patients With Uncontrolled Arterial Hypertension - Hyper 2
The purpose of this study is to evaluate the effectiveness of the use of artificial intelligence in home monitoring in patients with uncontrolled arterial hypertension.
- Conditions
- Essential Hypertension, Metabolic Cardiovascular Syndrome, Heart Disease Risk Factors
- Trial name
- Hyper2 (NCT05843682)
- Testing
- Using the Avatr App
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Pre-Hypertension
Study of Hispanics to Assess Risk Prevention in Prehypertension
The purpose of this study is to assess the efficacy of lifestyle modification in reducing blood pressure values in Hispanics at risk for hypertension.
- Trial name
- SHARPP (NCT01025323)
- Testing
- Lifestyle modification
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Florida Heart Research Institute
Type 2 Diabetes Mellitus, Hypertension
Vitamin D and Omega-3 Inhibit Metabolic Syndrome
The study will test the hypothesis that supplementing the diet of subjects with Metabolic Syndrome with 2000 IU vitamin D and 1.8 g omega-3 fatty acids (EPA + DHA) per day, will facilitate weight loss, improve body composition…
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, Obesity
- Trial name
- NCT01326442
- Testing
- low glycemic diet, vitamin D omega-3
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Guelph
Cardiovascular Diseases, Coronary Disease
Genetic Markers of CHD Risk in Men and Women
To investigate the association of selected genetic markers of inflammation and endothelial activation with the occurrence of non-fatal acute myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00090454
- Sponsor
- State University of New York at Buffalo
Healthy Older Adults
Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults
The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease.
- Trial name
- NCT07649005
- Testing
- low sodium/low potassium diet, high sodium/low potassium diet, high sodium/high potassium diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Atherosclerotic Disease
Telomeres and Arterial Aging
The prevailing view in telomere epidemiology is that leukocyte telomere length (LTL) is associated with atherosclerosis and accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative…
- Trial name
- TELARTA (NCT02176941)
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Risk Factor, Cardiovascular Diseases
Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Dietary Approaches to Stop Hypertension (DASH) diet, a dietary pattern that emphasizes fruits and…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Coronary Heart Disease, Stroke
- Trial name
- NCT03542370
- Testing
- DASH dietary pattern
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Multiple Myeloma, High Risk Smoldering Multiple Myeloma
Ixazomib (MLN9708) and Dexamethasone in High Risk Smoldering Multiple Myeloma: A Clinical and Correlative Pilot Study
The purpose of this study is to see what effects, good and/or bad, the combination of ixazomib and dexamethasone has on the patient and the smoldering multiple myeloma.
- Trial name
- NCT02697383
- Testing
- Ixazomib (MLN9708), Dexamethasone
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
African Americans With Hypertension.
Metro Atlanta Heart Disease Study - II (MAHDS II)
A 12-week treatment/control trial was implemented to assess the effects of a multi component lifestyle program on improvements in body mass index, weight, perceived stress and blood pressure in African American men and women who…
- Trial name
- NCT01235702
- Testing
- 12-week lifestyle modification
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Morehouse School of Medicine
Preterm Birth, Coagulation Protein Disorders
Stratifying Risk for Intracerebral Haemorrhage
This study aims to investigates the role of gestational age on the prevalence of coagulation factors and components of the complement system in preterm- (≤32+0 weeks) and term neonates (≥37+0 weeks) and their role for the…
- Conditions
- Preterm Birth, Coagulation Protein Disorders, Coagulation Disorder Neonatal
- Trial name
- NEW_STRATEGI (NCT04140812)
- Testing
- mass spectrometry (LC-MS/MS)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension
A Pilot Study of Changing Medication Adherence In Hypertensive African-American Patients
We will conduct an empirical test of the two intervention approaches under study. Specifically, we seek to determine the potential differential impact of positive affect induction and self affirmation.
- Trial name
- NCT00248937
- Testing
- Positive affect and self-affect induction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Myocardial Infarction, Autonomic Dysfunction
The Usefulness of Assessing Heart Rate Variability in Patients With Acute Myocardial Infarction
Aims heart rate variability (HRV) assessment in patients with acute myocardial infarction who undergo primary percutaneous coronary intervention (PCI); measurement of HRV using a device approved for medical use in Europe…
- Trial name
- HeaRt-V-AMI (NCT05098977)
- Testing
- Heart rate variability measurement, Percutaneous coronary intervention
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Diabetic Retinopathy, Diabetic Blindness
Patient Navigator Intervention for Diabetic Retinopathy
This is a pilot study of a patient navigator intervention for people living with diabetes and at high risk of diabetic blindness.
- Trial name
- SEEN (NCT05188703)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University
Venous Thromboembolism, Deep Vein Thrombosis
Detecting the Impact of Statin Therapy On Lowering Risk of Venous Thrombo-Embolic Events (DISOLVE)
Patients with cancer have a high risk of developing venous blood clots or thromboembolism (VTE). In an effort to target patients at highest risk of VTE for thromboprophylaxis (protective treatment for blood clots), numerous…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Neoplasms
- Trial name
- DISOLVE (NCT01524653)
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Vermont
Hypercholesterolemia, Cardiovascular Risk Factor
Effect of Totum-070 on Lipid Metabolism in Moderate Hypercholesterolemic Subjects
This clinical study aims to assess the efficacy of TOTUM-070, a mix of 5 plant extracts, on lipid metabolism in moderate hypercholesterolemic subjects.
- Conditions
- Hypercholesterolemia, Cardiovascular Risk Factor, Dyslipidemias, Overweight and Obesity
- Trial name
- HEART (NCT04760951)
- Testing
- TOTUM-070
- Where
- 4 sites in France, Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Vascular Diseases, Leukoaraiosis
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
The primary aim of the current research project is to answer the question, whether plasma trimethylamine N-oxide (TMAO) level may be used as a marker of ischemic changes in the brain.
- Conditions
- Vascular Diseases, Leukoaraiosis, Ischemia, Cerebral
- Trial name
- NCT03903601
- Testing
- Magnetic Resonance Imaging (MRI), Blood samples collection, Neuropsychological tests
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Myocardial Infarction
Previous Cardiovascular Disease, Cardiovascular Risk Factors and Chest Pain in First Myocardial Infarction
Some myocardial infarctions (MI) occur as the first manifestation of atherosclerotic disease. Such MIs are important because of the high likelihood of missed opportunities for prevention.
- Trial name
- NCT01379131
- Where
- United Kingdom
- Volunteers
- 9,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Liver Dysfunction, Thyroid
DEscripitive Patient Analysis to Enable Risk-based Quality Improvement Measures in a lArge iNternal mediCIne grouP Practice
Background: Clinical trials often include patients from large hospitals or university clinics. Information on patients cared for at offices from statutory health insurance-accredited physicians represent evidence gaps.
- Conditions
- Liver Dysfunction, Thyroid, Atherosclerosis, Heart Failure
- Trial name
- EMANCIPATE (NCT06178302)
- Volunteers
- 1,000 people
- Sponsor
- Imed19
Hypertension, Cardiovascular Risk Factor
Text Message Intervention for Prevention of Cardiovascular Disease in Primary Care Patients With Hypertension
The primary objective of the study is to examine the impact of lifestyle advices, administered through regularly sent SMS, on hypertension in a primary health care setting.
- Trial name
- PUSH-ME (NCT03442257)
- Testing
- SMS
- Where
- 3 sites in Sweden
- Volunteers
- 59 people
- Sponsor
- Lund University
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