Clinical trials: Vascular Disease Risk
Non ST Segment Elevation Myocardial Infarction, Unstable Angina
Patients With High-risk Acute Coronary Syndrome Without ST-segment Elevation
This non-inferiority study aims at comparing Versa® to the reference enoxaparin (Clexane®, Sanofi-Aventis) in patients with high-risk unstable angina and NSTEMI.
- Trial name
- VECOR (NCT01356992)
- Testing
- Enoxaparin
- Where
- 5 sites in Brazil
- Volunteers
- 62 people
- Sponsor
- Eurofarma Laboratorios S.A.
Metabolic Diseases, Endocrine System Diseases
Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
The overall objective of LUCHAR Specific Aims 4.1 and 4.2 is to assess the additional contribution of cardiovascular disease (CVD) risk markers to traditional biomedical risk factors in the prediction of pre-clinical CVD.
- Conditions
- Metabolic Diseases, Endocrine System Diseases, Heart Disease, Vascular Diseases
- Trial name
- NCT00935766
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Denver Health and Hospital Authority
Pre-Eclampsia, Pregnancy
Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia
Preeclampsia is associated with significant maternal and fetal morbidity and mortality. Early identification and subsequent management of patients at risk of developing preeclampsia presents an ongoing challenge in prenatal care.
- Conditions
- Pre-Eclampsia, Pregnancy, Hypertension
- Trial name
- NCT01351428
- Testing
- Nifedipine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Stroke
A Study to Assess Stroke Risk Among Users of Typical Versus Atypical Antipsychotics Stratified by Broad Age Group
The purpose of this study is to extend the recent Food and Drug Administration (FDA) Sentinel tabulations regarding stroke risk among new users of typical and atypical antipsychotics to participants who were aged 18-64 years and…
- Trial name
- NCT04002700
- Testing
- Haloperidol, Typical Antipsychotics, Atypical Antipsychotics
- Where
- United States
- Volunteers
- 1,234,412 people
- Sponsor
- Janssen Research & Development, LLC
Hypertension
Impact of Ramadan on Achieving Joint National Committee (JNC) 7 Treatment Goals in CV Risk Patients
This is an out-patient based prospective, multi-centre, observational post-marketing surveillance study amongst internists and cardiologists.
- Trial name
- NCT01853839
- Where
- 132 sites in Algeria, Egypt and 3 more
- Volunteers
- 1,674 people
- Sponsor
- Boehringer Ingelheim
Atherosclerosis
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
The study was designed to test whether short-term treatment with a very low-dose combination of fluvastatin and valsartan could induce improvement of endothelial function, arterial stiffness, vascular inflammation, oxidative…
- Trial name
- AGE-ZT (NCT03393377)
- Testing
- fluvastatin 10 mg and valsartan 20 mg
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Atherosclerotic Cardiovascular Disease, Type 2 Diabetes
High-intensity Rosuvastatin vs. Moderate-intensity Rosuvastatin/Ezetimibe in High Atherosclerotic Cardiovascular Disease Risk Patients With Type 2 Diabetes
To assess the efficacy and safety of moderate-intensity rosuvastatin/ezetimibe compared to high-intensity rosuvastatin in high atherosclerotic cardiovascular disease risk patients with type 2 diabetes
- Trial name
- NCT03403556
- Testing
- Rosuvamibe, Monorova
- Where
- 6 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Yuhan Corporation
Diabetic Retinopathy
Extension Study of the Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy
This multicenter, open-label extension study will evaluate the long-term tolerability and safety for patients completing study CSMS995 0802.
- Trial name
- NCT00248157
- Testing
- Octreotide acetate in microspheres
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
Carotid Artery Stenosis
Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis
A prospective, multicenter, single-arm, open label clinical study to evaluate the safety and effectiveness of MicroVention, Inc.
- Trial name
- NCT02657707
- Testing
- Roadsaver™ Carotid Artery Stent Device, Nanoparasol® Embolic Protection System
- Where
- 37 sites in United States
- Volunteers
- 295 people
- Sponsor
- Microvention-Terumo, Inc.
Intermittent Claudication
The Effects of Fish Oil Supplements During Supervised Exercise Therapy in Patients With Intermittent Claudication
Intermittent claudication (IC) is caused by peripheral arterial disease and has a high morbidity and mortality. Etiologic factors are similar to those of cardiovascular disease.
- Trial name
- FISHTIC (NCT02152930)
- Testing
- Omega-3 fatty acids
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Medical Center Alkmaar
Atrial Fibrillation, Cardiovascular Diseases
Atrial Fibrillation Incidence, Risk Factors and Genetics
To assess the risk of incident atrial fibrillation after stopping anti-hypertensive medication including beta-blockers and ACE inhibitors.
- Conditions
- Atrial Fibrillation, Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00021905
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Brain and Central Nervous System Tumors
Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma
RATIONALE: Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor, such as…
- Trial name
- NCT00895622
- Testing
- 54 Gy radiotherapy, 60 Gy radiotherapy
- Where
- 78 sites in United States, Canada
- Volunteers
- 244 people
- Sponsor
- Radiation Therapy Oncology Group
Acute Myocardial Infarction, Cardiogenic Shock
Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock
In the present study, we aim to investigate the effects of dobutamine infusion and/or a single intravenous (IV) dose of the IL-6 antagonist Tocilizumab administered after percutaneous coronary intervention (PCI) to patients with…
- Trial name
- DOBERMANN (NCT05350592)
- Testing
- Tocilizumab, Dobutamine, NaCl 0.9%
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Systemic Sclerosis, Preeclampsia
Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis?
Background: Pre-eclampsia, defined by the association of an arterial hypertension and significant proteinuria after 20 weeks of gestation, complicates 1 to 2% of pregnancies in France.
- Conditions
- Systemic Sclerosis, Preeclampsia, Vascular Complications
- Trial name
- PREVASCLERO (NCT04363021)
- Where
- 10 sites in France
- Volunteers
- 378 people
- Sponsor
- University Hospital, Brest
Subarachnoid Hemorrhage, Aneurysmal
Risk Factors for Aneurysm Rebleeding
The purpose of this study is to examine the risk factors for aneurysm rebleeding.
- Trial name
- NCT01567449
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fujian Medical University
Cognitive Impairment, Stroke
Effect of a fNIRS-based Personalized Multi-domain Intervention on Cognitive in Elderly Population With High Risk of Stroke
This functional near-infrared spectroscopy-based personalized multidomain intervention study aims to prevent cognitive impairment and reduce dementia and cerebrovascular events in 45-74 years old persons with high risk of stroke…
- Conditions
- Cognitive Impairment, Stroke, Dementia
- Trial name
- NCT05930249
- Testing
- Personalized multidomain intervention
- Where
- China
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asymptomatic Carotid Artery Stenosis
" Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke "
The purpose of this study is to determine whether carotid surgery combined with optimal medical therapy improves long-term survival free of ipsilateral stroke in patients with asymptomatic carotid stenosis at higher-than-average…
- Trial name
- ACTRIS (NCT02841098)
- Testing
- Carotid endarterectomy (CEA) combined with optimal medical therapy (OMT), Optimal medical therapy alone
- Where
- 23 sites in France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier St Anne
Obesity, Atherosclerosis
Effect of Pyramidal Training on Selected Risk Factors of Atherosclerosis
The study will be conducted on fifty women with central obesity. Their ages will be from 30-40 years old. They will be selected from Al Hayat specialized Hospital in Cairo, Egypt and The participants will be randomly assigned…
- Trial name
- NCT06077552
- Testing
- pyramidal training by treadmill
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypertension
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
The purpose of this study is to compare the impact of two blood pressure lowering treatments (high dose quinapril versus low dose quinapril plus amlodipine) on variations in heart rate over 24 hours.
- Trial name
- NCT00313547
- Testing
- Quinapril 40 mg, Quinapril 10 mg and amlodipine 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Multiple Myeloma, Shortness of Breath
Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib
This study will explore why some multiple myeloma patients who receive carfilzomib (an anti-cancer medication) experience shortness of breath while others do not.
- Conditions
- Multiple Myeloma, Shortness of Breath, Dyspnea, Cardiotoxicity
- Trial name
- NCT04827563
- Testing
- EndoPAT, Blood Pressure Cuff, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
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