Clinical trials: Vascular Disease Risk
Coronary Heart Disease
A Study of RO4607381 in Patients With Coronary Heart Disease (CHD) or a CHD Risk Equivalent.
This 2 arm study will investigate the efficacy and safety of RO4607381 in patients with coronary heart disease, or CHD risk equivalent.
- Trial name
- NCT00353522
- Testing
- dalcetrapib
- Where
- 17 sites in United States, Germany
- Volunteers
- 135 people
- Sponsor
- Hoffmann-La Roche
Heart Failure, Cardiomyopathies
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure
The purpose of this study is to determine whether galectin-3 binding protein plasma levels can predict adverse cardiovascular events in patients with coronary artery disease and/or heart failure.
- Conditions
- Heart Failure, Cardiomyopathies, Coronary Artery Disease
- Trial name
- GALACTIC (NCT01210157)
- Where
- Germany
- Volunteers
- 373 people
- Sponsor
- Heidelberg University
Diabetic Retinopathy
Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients
The investigator study evaluate the effect of different lipid lowering agents on the progression of diabetic retinopathy and other reduction of cardiovascular risk of diabetic patients
- Trial name
- NCT04140201
- Testing
- Simvastatin 40mg, Fenofibrate 200mg, Omega 3 fatty acid
- Volunteers
- 80 people
- Sponsor
- Alaa Hassan ElBaz
Coronary Artery Disease
Coronary Atherosclerosis Disease Early Identification and Risk Stratification by Noninvasive Imaging
The investigator prospectively enroll 30,000 outpatients who were suspected of coronary artery disease (CAD) and underwent cardiac computed tomography angiography (CTA).
- Trial name
- Creation (NCT03518437)
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II
As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT05050877
- Where
- China
- Volunteers
- 184,855 people
- Sponsor
- Guangdong Provincial People's Hospital
Multiple Myeloma
Isa-VRdlite for of Frail and/or Much Older Patients With High Risk Newly Diagnosed Multiple Myeloma Base on Circulating Plasma Cells
To evaluate the overall response rate, safety, and the 12-cycle clearance rate of circulating plasma cells (CPCs) in patients with newly diagnosed transplant-ineligible multiple myeloma stratified as high-risk based on…
- Trial name
- NCT07732712
- Testing
- Isatuximab, VRD
- Volunteers
- 15 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies
The purpose of this study is to determine the maximum tolerated dose (MTD) of TAK-901 in subjects with advanced hematological malignancies, and to further assess the safety and tolerability of TAK-901 at or below the MTD in an…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT00807677
- Testing
- TAK-901
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
High Bleeding Risk, Coronary Artery Disease
Zotarolimus vs Sirolimus Eluting Stent in High Bleeding Risk
Randomized, single-blind, single-center, non-inferiority clinical trial to compare target lesion failure (TLF) at 12 months in high bleeding risk patients who underwent elective coronary percutaneous intervention with a…
- Conditions
- High Bleeding Risk, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- ZEVS-HBR (NCT05240781)
- Testing
- Zotarolimus eluting stent, Sirolimus eluting stent
- Where
- Mexico
- Volunteers
- 280 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Coronary Syndrome, Chest Pain
High-Sensitivity Cardiac Troponin T to OPtimize Chest Pain Risk Stratification
This is a prospective observational cohort study of ED patients with acute chest pain or other symptoms suggestive of ACS. Blood samples will be collected from study participants for High-Sensitivity Cardiac Troponin T (hs-cTnT)…
- Trial name
- STOP CP (NCT02984436)
- Testing
- Blood Sample, HEART Score
- Where
- 6 sites in United States
- Volunteers
- 1,572 people
- Sponsor
- University of Florida
Aortic Valve Disease, Stroke
Swedish Study on STroke After TAVR
This study aims at studying the frequency of late stroke after transcatheter aortic valve replacement/implantation
- Trial name
- SWESTAT (NCT04086836)
- Testing
- TAVR
- Where
- Sweden
- Volunteers
- 4,600 people
- Sponsor
- Region Skane
Stroke, Osteoporosis
Assessment and Comparison of Osteoporosis Risk Factors After Stroke
The aim of this study is to evaluate the effects of stroke and associated clinical, functional, nutritional, and muscular factors, including handgrip strength, on bone mineral density and osteoporosis by comparing patients with…
- Trial name
- NCT07228611
- Testing
- Bone Mineral Density
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Neolifes Heart - Pulmonary Hypertension in Preterm Children
NeoLifeS is a cohort follow up study that prospectively collects data of regular care of children born preterm in the University Medical Center Groningen (UMCG) and aims to improve the quality of care for these children.
- Trial name
- NCT02729844
- Where
- Netherlands
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Intracranial Aneurysm
Risk Factors for Intracranial Aneurysm Recanalization After Endovascular Treatment.
Endovascular treatment is now the first line treatment for the management of intracranial aneurysms. However aneurysm recanalization is an important limitation to this treatment.
- Trial name
- ARETA (NCT01942512)
- Testing
- Endovascular treatment of intracranial aneurysm
- Where
- 22 sites in France
- Volunteers
- 1,275 people
- Sponsor
- CHU de Reims
Pulmonary Embolism
Catheter-Directed Pulmonary Reperfusion in Treatment of Pulmonary Embolism Patients
Primary objective: to evaluate the success and mortality rates of catheter-directed reperfusion therapy in comparison to traditional use of systemic intravenous fibrinolytic therapy, will focus at safety of such management…
- Trial name
- NCT04911192
- Testing
- mechanical fragmentation, In Situ thrombolysis
- Volunteers
- 60 people
- Sponsor
- Assiut University
Diabetic Foot Ulcers, Diabetes Mellitus
Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers (DFUs)
Diabetes mellitus is a chronic disease that occurs either when pancreas does not produce enough insulin or when the body can't use it effectively.
- Trial name
- DFUs (NCT07193992)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Coagulopathy
Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
The purpose of this study is to compare rapid thrombelastography (r-TEG) with conventional coagulation testing for diagnosing and treating coagulation abnormalities in severely injured patients who are likely to require…
- Trial name
- NCT01536496
- Testing
- Blood product transfusion based on conventional coagulation tests., Blood product transfusion based on rapid thrombelastography (r-TEG) results.
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Denver Health and Hospital Authority
Restless Legs Syndrome, Stroke
Restless Legs Syndrome in Stroke Patients
Our study aimed to examine a possible association between Restless legs syndrome and cerebrovascular disease, by examining patients during hospitalization for acute stroke or transient ischemic attack, in a matched case-control…
- Conditions
- Restless Legs Syndrome, Stroke, Transient Ischemic Attack
- Trial name
- NCT01967303
- Volunteers
- 447 people
- Sponsor
- Rambam Health Care Campus
Post Thrombotic Syndrome, Venous Thromboembolism
Long Term Assessment of Post Thrombotic Syndrome : OPTIMEV Study ( SPOT )
Post-thrombotic syndrome (PTS) is a frequent and burdensome complication of deep-vein thrombosis (DVT). In the absence of curative treatment of established PTS, its management is based on the prevention of its occurrence thanks…
- Conditions
- Post Thrombotic Syndrome, Venous Thromboembolism, Cardiovascular Diseases
- Trial name
- SPOT (NCT03054727)
- Testing
- Villalta phone score > or = to 5, Villalta phone score < 5
- Where
- France
- Volunteers
- 2,475 people
- Sponsor
- Association des Médecins Vasculaires Hospitaliers
Transient Ischemic Attack (TIA)
Canadian TIA Score Versus ABCD2 Score in Risk Stratification of Transient Ischemic Attack (TIA)
This study aims to evaluate the superiority of a clinical score (Canadian TIA score) compared to the currently more widely used score in clinical practice (ABCD2 score) in stratifying the risk of stroke or carotid…
- Trial name
- NCT06718075
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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