Clinical trials: Vascular Disease Risk
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
ANCA Associated Vasculitis (AAV)
PET Assessment of Disease Activity and Cardiovascular Disease Risk in ANCA-associated Vasculitis
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune condition characterised by inflammation of small blood vessels.
- Trial name
- PANDA-VASC (NCT07258524)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Acute Coagulopathy
Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
The purpose of this study is to compare rapid thrombelastography (r-TEG) with conventional coagulation testing for diagnosing and treating coagulation abnormalities in severely injured patients who are likely to require…
- Trial name
- NCT01536496
- Testing
- Blood product transfusion based on conventional coagulation tests., Blood product transfusion based on rapid thrombelastography (r-TEG) results.
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Denver Health and Hospital Authority
Hypertension in Pregnancy, Preeclampsia
Blood Pressure Monitoring in Postpartum Women at Risk of Hypertension
Cardiovascular disease and hypertensive disorders of pregnancy (HDP) are the leading causes of maternal morbidity and mortality in the United States.
- Conditions
- Hypertension in Pregnancy, Preeclampsia, Gestational Hypertension, Chronic Hypertension With Pre-Eclampsia
- Trial name
- NCT05457504
- Testing
- Remote blood pressure monitoring, Usual Care
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease (CAD)
Epicardial Delivery of XC001 Gene Therapy to Promote Angiogenesis in CAD Patients Undergoing Treatment With CABG
This is a 26-week (with a 26-week extension) multicenter, randomized, double-blind, placebo-controlled Phase 2 study of XC001 versus placebo.
- Trial name
- EXACT-CABG (NCT07118449)
- Testing
- XC001
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- XyloCor Therapeutics, Inc.
Ischemic Attack, Transient, Stroke
MIDNOR-TIA - a Study of 600 Patients With Transient Ischemic Attack
Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low…
- Trial name
- MIDNOR-TIA (NCT02038725)
- Where
- 8 sites in Norway
- Volunteers
- 584 people
- Sponsor
- Norwegian University of Science and Technology
Aortic Aneurysm
Evaluation of Aortic Aneurysms With Focus on Wall Stress and Wall Rupture Risk
Retrospective study to evaluate the impact of computational wall stress analysis based on computed tomography (CT) of ruptured and not-ruptured aortic aneurysms as an additional predictor for rupture with dedicated software.
- Trial name
- NCT02800876
- Testing
- CT-acquisition
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
High Bleeding Risk, Coronary Artery Disease (CAD)
Drug-eluting Balloon Versus Drug-eluting Stent for High Bleeding Risk Angioplasty
Randomized, single-blind, single-center, non-inferiority clinical trial to compare target lesion failure (TLF) at 12 months in high bleeding risk patients undergoing elective coronary percutaneous intervention comparing…
- Conditions
- High Bleeding Risk, Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI)
- Trial name
- DEBORA (NCT04885816)
- Testing
- Drug Eluting Balloon (DEB), Drug Eluting Stents (DES)
- Where
- Mexico
- Volunteers
- 5 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Pulmonary Embolism (PE)
Acostream Use in Patients With High Risk and Intermediate-risk Acute Pulmonary Embolism
The registry is to evaluate the safety and feasibility of catheter-directed aspiration for patients with high-risk and intermediate-high-risk pulmonary embolism using Acostream.
- Trial name
- NCT06946732
- Testing
- Acostream aspiration
- Where
- China
- Volunteers
- 127 people
- Sponsor
- RenJi Hospital
Depression
Depression and Cardiovascular Risk Markers: Effects of Rosuvastatin Therapy
The purpose of this study is to investigate whether rosuvastatin decreases measures of inflammation in depressive patients.
- Trial name
- DECAMERONE (NCT00951132)
- Testing
- rosuvastatin
- Where
- Norway
- Sponsor
- University Hospital, Akershus
Blood Pressure, Lifestyle Risk Reduction
Blood Pressure Control in ESH Excellence Centres
In the BP-CON-ESH study we are going to include and analyze treated hypertensive patients seen consecutively by the ESH Excellence Centres.
- Conditions
- Blood Pressure, Lifestyle Risk Reduction, White Coat Hypertension
- Trial name
- BP-CON (NCT04295434)
- Where
- 46 sites in Armenia, Austria and 20 more
- Volunteers
- 3,000 people
- Sponsor
- Clinical Hospital Centre Zagreb
Hypertension
Evaluation of the Effect of Telmisartan on Blood Pressure Control of High Risk Patients
The study is designed to evaluate the effect of treatment with Micardis/MicardisPlus on blood pressure and its ability to reduce different indicated cardiovascular risk scores.
- Trial name
- NCT01108809
- Testing
- Telmisartan or Telmisartan and Hydrochlorthiazide
- Where
- 49 sites in Romania
- Volunteers
- 295 people
- Sponsor
- Boehringer Ingelheim
Hypertension
A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
This is a randomized, double-blind, placebo-controlled study comparing the efficacy of nebivolol and atenolol at improving small artery elasticity and reducing cardiovascular disease risk in subjects with early vascular disease.
- Trial name
- EVIDENCE (NCT01522950)
- Testing
- Nebivolol, atenolol
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Minnesota
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Hypertrophic Cardiomyopathy Pilot Study
This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from…
- Trial name
- NCT02806479
- Testing
- Observational: Arrhythmogenic Substrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Hypertension
Potato Consumption and Risk of Hypertension
Government has popularized potatoes as a major staple food in China. Potato, a potassium-rich food with high glycemic responses after consumption, exhibits unclear effects on hypertension.
- Trial name
- NCT03431376
- Volunteers
- 11,763 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Craniopharyngioma, Apoplexy
Craniopharyngioma With Tumoral Hemorrhage
Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected.
- Trial name
- NCT04937335
- Testing
- intratumoral hemorrhage
- Volunteers
- 185 people
- Sponsor
- Tongji Hospital
Intracranial Arteriovenous Malformations
Multimodal Imaging Techniques in Assessing the Surgical Risk for Eloquent Arteriovenous Malformations
Microsurgical resection for eloquent arteriovenous malformations (AVMs) remains challenging. Currently, there are only two grading systems concerning pretreatment assessment of brain AVMs: the Spetzler-Martin grading system…
- Trial name
- MITASREAVM (NCT02868008)
- Testing
- Microsurgical resection of brain AVMs
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Excessive Supraventricular Ectopies or Short Atrial Runs (ESVEA)
Rivaroxaban Versus Standard of Care for Patients With Excessive Atrial Ectopy or Short Atrial Runs and High Embolism Risk
The primary objective of the Short Run AF study is to evaluate the efficacy and safety of long term anticoagulation with rivaroxaban against standard of care (SOC) in patients with ESVEA and CHA2DS2VASC score ≥3 on the incidence…
- Trial name
- SHORT RUN AF (NCT05487950)
- Testing
- Rivaroxaban group
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Embolism
Low Molecular Weight Heparin for 72 Hours Followed by Dabigatran for Acute Intermediate-Risk Pulmonary Embolism.
This prospective, multicenter, multinational, phase IV, interventional single-armed (management) trial will focus on the safety, efficacy and cost-effectiveness of a new oral anticoagulant in the treatment of patients with acute…
- Trial name
- PEITHO-2 (NCT02596555)
- Testing
- Dabigatran
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Prof. Stavros Konstantinides, MD
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