Clinical trials: Vascular Disease Risk
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease (ASCVD)
Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary Prevention
This study will evaluate the effectiveness and safety of combining two different types of PCSK9 inhibitors, inclisiran and alirocumab, in patients with high cardiovascular risk who are unable to tolerate statins.
- Trial name
- PCSK9-DUO (NCT07581808)
- Testing
- Inclisiran, Alirocumab
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Acute Ischemic Stroke
Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study
(1) The main purpose To explore the predictive value of human microbiome and its metabolome for adverse prognosis in patients with acute ischemic stroke (AIS). (2) Secondary purposes 1.
- Trial name
- NCT06240468
- Testing
- not have
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Coronary Heart Disease
Family Heart Health Program: Randomized, Controlled Trial
Background: Family members (spouses, siblings, offspring) of patients with coronary heart disease (CHD) may themselves be at increased risk for developing CHD for genetic, biochemical and/or behavioural reasons.
- Trial name
- FHHP-RCT (NCT00552591)
- Testing
- 12-week risk reduction program, managed by a Heart Health Educator
- Where
- Canada
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Diabetes Mellitus, Hypertension
Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care
The trial will examine whether a centralized Prevention Health \& Cardiovascular Risk Service (PHCVRS) run by clinical pharmacists at the University of Iowa can be implemented in primary care offices and whether it can improve…
- Conditions
- Diabetes Mellitus, Hypertension, Coronary Artery Disease, Atrial Fibrillation
- Trial name
- ICARE (NCT01983813)
- Testing
- PHCVRS Intervention, Personal Health Record
- Where
- 12 sites in United States
- Volunteers
- 302 people
- Sponsor
- Korey Kennelty
Pulmonary Embolism
Role of Echocardiography in Pulmonary Embolism
1. To analyze the diagnostic and prognostic value of echocardiographic parameters. 2. Prediction of APE-related 30-day mortality and adverse out comes. 3.
- Trial name
- NCT04020250
- Testing
- Echocardiography
- Volunteers
- 30 people
- Sponsor
- Assiut University
COVID, Hypertension
Drug Safety and the Occurrence of Complications During Hospitalization in Patients With COVID-19
Hospitalized patients with COVID-19 will be included in the study in centers around Poland. After the hospitalization, a short questionnaire will be completed, including pre-hospitalization diagnoses, pre-hospitalization…
- Conditions
- COVID, Hypertension, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- COR-CARDIO (NCT04374110)
- Testing
- Clinical data
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Thromboembolism
Evaluation of the Risk of VTE Among Patients Hospitalized in Non-surgical Departments
Patients hospitalized in internal wards are at risk for VTE. The current guidelines recommend the use of thromboprophylaxis for 7-10 days among patients who are at increased risk for VTE.
- Trial name
- NCT03073915
- Volunteers
- 4,000 people
- Sponsor
- Hadassah Medical Organization
Cardiovascular Diseases, Myocardial Infarction
Effect of Drug Therapy on Reinfarction Risk in Women
To evaluate the safety of calcium-channel blockers in the secondary prevention of myocardial infarction in women.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005389
- Sponsor
- University of Washington
High Risk of Significant Coronary Artery Disease
Cardiac GSI Feasibility Study
The recently introduced Computed tomography (CT) scanner, Discovery CT750 HD (GE Healthcare, Milwaukee), incorporates a battery of innovations aimed at improving diagnostic image quality, evaluating perfusion and assessing for…
- Trial name
- NCT01816750
- Testing
- Cardiac GSI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospital Plymouth NHS Trust
Immune Thrombocytopenia
Risk Factors for Thrombosis in Immune Thrombocytopenia
Immune thrombocytopenia (ITP) is a rare autoimmune disease (annual incidence: 3-4/105 inhabitants) leading to an increased risk of spontaneous bleeding.
- Trial name
- RiFT-ITP (NCT03820960)
- Where
- France
- Volunteers
- 10,039 people
- Sponsor
- University Hospital, Toulouse
Neoplasms, Deep Vein Thrombosis
Outpatient Treatment Of Deep Venous Thrombosis Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
Study Plan: Adult cancer patients who have a low risk profile and present with DVT will receive dalteparin 200 IU/kg subcutaneously daily (based on actual body weight with a maximum dose of 18,000 IU).
- Trial name
- NCT00041782
- Testing
- Dalteparin (Fragmin)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation, Stroke
Computerized Decision Support to Prevent Stroke in Atrial Fibrillation
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for…
- Trial name
- AF-ALERT3 (NCT06355986)
- Testing
- Alert-based computerized decision support
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Brigham and Women's Hospital
Symptomatic Haemorrhoidal Disease Requiring Surgical Management
Randomized Controlled Trial Comparing Transanal Doppler-guided Arterial Ligation With Mucopexy and Stapled Haemorrhoidopexy
This multicentre RCT aims to compare two surgical treatments of haemorrhoidal disease: doppler-guided arterial ligation with mucopexy (DGALM) and stapled haemorrhoidopexy according to Longo (SH).
- Trial name
- LIGALONGO (NCT01240772)
- Testing
- doppler-guided arterial ligation with mucopexy, stapled haemorrhoidopexy according to Longo
- Where
- 22 sites in France
- Volunteers
- 407 people
- Sponsor
- Nantes University Hospital
Coronary Artery Disease With Myocardial Infarction
Pragmatic Trial Comparing Symptom-Oriented Versus Routine Stress Testing in High-Risk Patients Undergoing Percutaneous Coronary Intervention
The primary objective of the POST-PCI trial is to compare the clinical outcomes of a post-percutaneous coronary intervention(PCI) aggressive management strategy of routine noninvasive functional testing to a usual-care strategy…
- Trial name
- POST PCI (NCT03217877)
- Testing
- routine stress testing, No Routine stress testing
- Where
- 11 sites in South Korea
- Volunteers
- 1,700 people
- Sponsor
- Seung-Jung Park
Venous Thromboembolism
the Effectiveness of Different Risk Scales In Predicting VTE in Respiratory Inpatients
To compare the predictive effectiveness of the Caprini risk assessment model, the Padua risk assessment model and the VTE risk assessment in medical patients mentioned in the 2018 edition of the Guidelines for the diagnosis…
- Trial name
- NCT04963374
- Testing
- risk evolution scale
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Treated Hypertension
Pilot Study: Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Prevention
The primary aim of the pilot study is to provide data that can be used to better determine sample size for the design of a larger clinical trial.
- Trial name
- NCT01780974
- Testing
- Lipoic Acid plus Omega-3 Fatty Acids
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Oregon Health and Science University
Ischemic Heart Disease Chronic, Diabetes Mellitus, Type 2
Lifestyle Intervention in Chronic Ischemic Heart Disease and Diabetes
Chronic ischemic heart disease and diabetes mellitus type II have one of the highest morbidity and mortality rates. Especially in the presence of both diseases, these risks increase exponentially.
- Trial name
- LeIKD (NCT03835923)
- Testing
- lifestyle intervention, usual care
- Where
- 10 sites in Germany
- Volunteers
- 502 people
- Sponsor
- Techniker Krankenkasse
Cerebral Small Vessel Disease
Biomarkers, Risk Assessment, Imaging, and Neurodegeneration in Cerebral Small Vessel Disease (BRAIN-CSVD)
The BRAIN-CSVD study is a single-center prospective cohort study focusing on cerebral small vessel disease (CSVD).Patients enrolled in this research will undergo assessments for vascular risk factors, cognitive and other…
- Trial name
- BRAIN-CSVD (NCT07093515)
- Testing
- No intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhejiang Hospital
Blood Pressure, Hypertension
PACESETTER: Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor
Program to Avoid Cerebrovascular Events through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor (PACESETTER) aims to assess the incorporation of its stroke intervention into 2 safety net/academic health…
- Conditions
- Blood Pressure, Hypertension, Mhealth
- Trial name
- NCT03401489
- Testing
- PACESETTER
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Northern California Institute of Research and Education
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