Clinical trials: Vascular Disease Risk
Preterm Birth, Periventricular Leukomalacia
Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth
Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational…
- Conditions
- Preterm Birth, Periventricular Leukomalacia, Brain Ischemia, Intracranial Hemorrhages
- Trial name
- NCT00120588
- Testing
- magnesium
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Rouen
Chronic Kidney Diseases, Hypertension
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an…
- Conditions
- Chronic Kidney Diseases, Hypertension, Diabetes Mellitus, Hyperuricemia
- Trial name
- NCT05476627
- Testing
- Biomarkers
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Arrhythmia, Acute Kidney Injuries
This is an Observational Study That Aims to Demonstrate Postoperative Risk Factors in Pediatric Cardiac Surgery
This retrospective observational study aims to identify risk factors for postoperative complications in children undergoing cardiac surgery at a tertiary hospital in Brazil.
- Conditions
- Arrhythmia, Acute Kidney Injuries, Sepsis, Pneumopathy
- Trial name
- PEDS-CARE (NCT06985082)
- Testing
- THERE IS NOT A INTERVENTION
- Volunteers
- 310 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypertension in Pregnancy
Prenatal Mindfulness & Hypertension Study
Hypertensive disorders of pregnancy are one of the greatest causes of death to mothers and babies. These disorders affect 1 out of every 10 pregnancies, the rate is increasing in the United States, and rate of recurrence is as…
- Trial name
- HTN (NCT03679117)
- Testing
- Mindfulness Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lifespan
Cardiovascular Risk Factor, Insulin Resistance
Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology
This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects…
- Conditions
- Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes
- Trial name
- HealthPals (NCT03167996)
- Testing
- Use of HealthPals (Telemedicine supported by digital health platform)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypertension, Dyslypidaemia
Reducing the Overall Risk Level in Patients Suffering From Metabolic Syndrome
This study will evaluate the efficacy of a multi factorial preventive scheme of action (including fluvastatin and valsartan) to reduce the overall risk level in patients with metabolic syndrome.
- Trial name
- LesScore (NCT00821574)
- Testing
- Fluvastatin, Valsartan, Hydrochlorothiazide
- Volunteers
- 144 people
- Sponsor
- Novartis
Myocardial Infarction
EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)
This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart…
- Trial name
- NCT04509674
- Testing
- Empagliflozin
- Where
- 439 sites in United States, Argentina and 20 more
- Volunteers
- 6,522 people
- Sponsor
- Boehringer Ingelheim
Acute Kidney Injury (Nontraumatic), Coronary Artery Disease
Contrast RISK (Reducing Injury Sustained by Kidneys)
Diagnostic and therapeutic cardiac catheterization procedures are important interventions to reduce the risk of death, avoid future cardiovascular events, and improve quality of life of people with heart disease.
- Trial name
- Contrast RISK (NCT03453996)
- Testing
- Intervention, Control
- Where
- 3 sites in Canada
- Volunteers
- 7,280 people
- Sponsor
- University of Calgary
Portal Vein Thrombosis, Local Cause
Risk Factors for Recurrence of Thrombosis or Thrombotic Extension, in the Event of Acute Non-cirrhotic Portal Vein Thrombosis Secondary to a Local Cause.
In case of acute portal vein thrombosis (PVT) prothrombotic factors are identified in about 60% of cases, while a local condition is present in 30% of cases.
- Trial name
- LOCAPORT (NCT05360641)
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Caen
Pre-hypertension
Different Dosages of Bioactive Wheat Peptides and Blood Pressure Level and CVD Risk Biomarkers in Healthy Subjects
In this study we will assess the effects of bioactive peptide rich wheat products on blood pressure and estimated cardiovascular disease risk.
- Trial name
- NCT02197910
- Testing
- Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence Low->High), Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence High->Low)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Myocardial Ischaemia
Comparison of the Effect of Two Anaesthesia Methods in Preventing Perioperative Myocardial Infarcation in Patients With Cardiac Risk Undergoing Total Knee Arthroplasty
Comparison of the effect of two anaesthesia methods in preventing perioperative myocardial infarction in patients with cardiac risk undergoing total knee arthroplasty
- Trial name
- NCT05340946
- Testing
- general anaesthesia, spinal anaesthesia
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Hypertrophic Cardiomyopathy Pilot Study
This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from…
- Trial name
- NCT02806479
- Testing
- Observational: Arrhythmogenic Substrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Contraception, Female Contraception
A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control
The purpose of the study is to use data from a health care information database to assess the risk of venous thromboembolism (blood clots), myocardial infarction (heart attacks), and stroke among women using a transdermal…
- Trial name
- NCT00377988
- Testing
- Transdermal Contraceptive System, Norgestimate-containing oral contraceptives with EE
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Abdominal Aortic Aneurysms, Thoracoabdominal Aneurysms
Physician-Modified Endografts for Complex Aortic Aneurysms and Thoracoabdominal Aneurysm Repair in High-Risk Patients
This single-arm FDA-monitored protocol intends to broaden endovascular device applicability using physician-modifications in patients who A) Have anatomical conditions not amenable to endovascular repair using currently marketed…
- Conditions
- Abdominal Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aortic Aneurysm
- Trial name
- PMEG (NCT07224230)
- Testing
- Physician Modified Endograft
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Steven Maximus
Atherosclerosis
Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis
The study hypothesis (or theory) is that monthly loss of iron before menopause may reduce women's risk of hardening of the arteries, or atherosclerosis.
- Trial name
- NCT00921011
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Ohio State University
Chronic Kidney Disease, Diabetes
Improving Chronic Disease Management With Pieces
ICD-Pieces (Parkland Intelligent e-Coordination and Evaluation System) trial is a National Institutes of Health (NIH) Healthcare Systems(HCS) Collaboratory demonstration project to improve management of patients with a triad of…
- Conditions
- Chronic Kidney Disease, Diabetes, Hypertension, High BP
- Trial name
- ICD-Pieces (NCT02587936)
- Testing
- Collaborative Model of Primary care and Subspecialty care
- Where
- 4 sites in United States
- Volunteers
- 18,268 people
- Sponsor
- University of Texas Southwestern Medical Center
Mood Disorders, Hypertension
Association of Mood With Risk for Atherosclerosis
The investigators will aim to determine the association of mood disorders (MDO) with preclinical and clinical cardiovascular (CVD) risk factors among children.
- Conditions
- Mood Disorders, Hypertension, Overweight and Obesity, Vascular Stiffness
- Trial name
- AuRA (NCT04298944)
- Testing
- Cardiovascular Assessments, Actigraphy, Laboratory assessments
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Johns Hopkins University
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