Clinical trials: Vascular Endothelial Function
Atherosclerosis, Cardiovascular Diseases
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
The INTENSITY-LOW study aims to answer if there are any limits to LDL reduction in relation to benefitting vascular health from a mechanistic viewpoint, and therefore potentially limitations to primary prevention in healthy…
- Trial name
- NCT03273972
- Testing
- Written Informed Consent, Inclusion/Exclusion check, Full Clinical Chemistry and Haematology Bloods
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Insulin Resistance
Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses.
- Trial name
- NCT00553995
- Testing
- salsalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston University
Coronary Arteriosclerosis, Endothelial Function
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
The purpose of this study is to determine the effect of orally given paracetamol on the vascular function and on 24-hour blood pressure in patients with coronary artery disease
- Trial name
- NCT00534651
- Testing
- Paracetamol
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea of Adult
Endothelial Function in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA), a condition that affects a quarter of the Western adults, triples the risk for cardiovascular diseases and increases all-cause mortality.
- Trial name
- NCT03122639
- Testing
- Atorvastatin 10mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Columbia University
Down Syndrome (Trisomy 21)
Vascular Function in Adults With Down Syndrome
Adults with Down syndrome (Ds) are often thought to have a lower risk of heart and blood vessel disease because they tend to have lower blood pressure (BP) and fewer heart attacks than people without Ds.
- Trial name
- VDS (NCT07630207)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Embolic Stroke of Undetermined Source, Endothelial Dysfunction
Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)
The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar…
- Trial name
- ESUS (NCT03609437)
- Where
- Greece
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Athens
Oxidative Stress, Endothelial Function
Uric Acid Effects on Endothelium and Oxydative Stress
Cardiovascular disease is the leading cause of mortality worldwide. Endothelial dysfunction (ED) is the main mechanism which leads to atherosclerosis, where the balance between pro and antioxidant factors results in a decreased…
- Conditions
- Oxidative Stress, Endothelial Function, Cardiovascular System, Hypertension
- Trial name
- NCT03395977
- Testing
- Febuxostat, Rasburicase
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Healthy
Differential Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Platelet, Endothelial and Vascular Function
The purpose of this study was to determine whether supplementation with oils enriched with long chain n-3 PUFA, either EPA or DHA, had a differential effect on platelet, endothelial and vascular function.
- Trial name
- NCT01735357
- Testing
- EPA-rich triacylglycerol oil, DHA-rich triacylglycerol oil
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- King's College London
Atherosclerosis
Vascular Effects of Ezetimibe/Simvastatin and Simvastatin on Atherosclerosis
Multiple clinical trials, using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), have shown benefit in the primary and secondary prevention of atherosclerotic complications.
- Trial name
- NCT00560170
- Testing
- Simvastatin (Zocor), 10mg/10mg of Ezetimibe/Simvastatin (Vytorin)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Vascular Formation
Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force
This study will evaluate the effects of NHLBI's employee exercise program, Keep the Beat, on blood vessel function. Damage to blood vessels can cause narrowing of the vessels, resulting in reduced blood flow to parts of the body…
- Trial name
- NCT00246883
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
NSTEMI
COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients
Colchicine has antiinflammatory properties. It has been shown to be effective in improving outcome in stable coronary disease. The exact mechanism is unclear.
- Trial name
- CODEN (NCT02095522)
- Testing
- Colchicine
- Where
- 2 sites in Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Artery Disease
Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as coronary artery disease (CAD) and cardiovascular high risk. 2.
- Trial name
- NCT02174939
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Aging, Endothelial Dysfunction
Fisetin to Improve Vascular Function in Older Adults
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults.
- Conditions
- Aging, Endothelial Dysfunction, Arterial Stiffness
- Trial name
- NCT06133634
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Endothelial Dysfunction
Endothelial Function in Human Arteries
Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to assess changes in endothelial…
- Trial name
- NCT00848302
- Testing
- L-arginine
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
ANCA Associated Vasculitis, Cardiovascular Diseases
ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)
ANCA-associated vasculitis is an autoimmune disease that causes damage to blood vessels. This leads to organ damage with the number of organs affected and the severity of damage varying significantly between patients.
- Conditions
- ANCA Associated Vasculitis, Cardiovascular Diseases, Kidney Diseases
- Trial name
- SPARVASC (NCT05630612)
- Testing
- Sparsentan
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Aging, Inflammation
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
- Trial name
- NCT03889158
- Testing
- Typhoid Vaccine, Ascorbic Acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University