Clinical trials: Vascular Endothelium
Periodontitis, Periodontitis (Stage 3)
Evaluation of Albumin Platelet-Rich Fibrin Following SRP in Patients With Periodontitis
The study aims to investigate whether application of albumin platelet-rich fibrin (Alb-PRF) into the gum pockets after scaling and root planing (SRP) can improve healing in patients with Stage III Grade B periodontitis.
- Trial name
- NCT07363135
- Testing
- Albumin platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetic Macular Edema
Anterior and Posterior Segment Vascular Changes Following Laser and Anti-Vascular Endothelial Growth Factor (VEGF) Treatment of Diabetic Retinopathy
The study will investigate changes in the structure and function of blood vessels in the front and back of the eye following laser and anti-VEGF treatments for sight-threatening diabetic eye disease.
- Trial name
- VEGF (NCT01196325)
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Macular Edema
Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Alone Versus Ozurdex Given Every 3 Months for Treatment of Persistent Diabetic Macular Edema
To determine if there is visual benefit with Ozurdex treatment every three months compared to monthly anti-VEGF alone, in subjects with persistent diabetic macular edema.
- Trial name
- NCT02036424
- Testing
- Ozurdex, Bevacizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Raj K. Maturi, MD
Diabetic Retinopathy, GLP-1
Assessment of Retinal-Angio Findings In Patients With Diabetes Type II Treated With Novel Antidiabetic Therapies
ARIADNE is a prospective observational cohort study of patients with type 2 diabetes mellitus (T2DM) treated with daily metformin and scheduled to initiate treatment with newer antidiabetic agents, such as sodium-glucose…
- Conditions
- Diabetic Retinopathy, GLP-1, SGLT 2 Inhibitors, Endothelial Dysfunction
- Trial name
- ARIADNE (NCT07602348)
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Athens
Inflammatory Lung Diseases, Hemoptysis
The Expression of Serum Angiogenesis Marker in Patients Presenting With Hemoptysis
Vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) are major mediators of angiogenesis and are induced by tissue inflammation and hypoxia.
- Trial name
- NCT01171768
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Samsung Medical Center
Vascular Diseases
Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS
Aging is inevitable and is the primary risk factor for developing cardiovascular disease. The molecular mechanisms that drive vascular dysfunction in the context of aging are incompletely understood.
- Trial name
- NCT04200560
- Testing
- Rhythmic Handgrip Exercise, Chronic Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
End Stage Renal Disease, Cardiovascular Diseases
Comparison of MCO HD on Markers of Vascular Health Compared With On-Line Haemodiafiltration
The aim of this study is to evaluate haemodialysis treatment using a medium cut-off dialysis membrane (Theranova) compared with on-line haemodiafiltration treatment with respect to markers of endothelial health (plasma…
- Conditions
- End Stage Renal Disease, Cardiovascular Diseases, Inflammation
- Trial name
- MoDal (NCT03510520)
- Testing
- Medium Cut-Off Haemodialysis, On-Line Haemodiafiltration
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Manchester University NHS Foundation Trust
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Rheumatoid Arthritis, Sedentary Behavior
Breaking up Sedentary Time in Rheumatoid Arthritis
This study will verify the effects of breaking up sitting time with short bouts of light intensity walking on vascular function in women with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Sedentary Behavior, Endothelial Dysfunction
- Trial name
- NCT05284110
- Testing
- Physical activity
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Liverpool John Moores University
Cognitive Impairment, Executive Dysfunction
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and…
- Conditions
- Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT02122198
- Testing
- Leuprolide acetate, Estradiol, Medroxyprogesterone
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Coronary Syndrome
Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase I
The purpose of this randomized, multi-site, clinical trial is to determine whether intensive therapy consisting of cholesterol-lowering statin drugs plus apheresis to cleanse the blood of low-density lipoprotein (LDL) cholesterol…
- Trial name
- PREMIER (NCT01004406)
- Testing
- intensive LDL-lowering therapy, standard statin monotherapy
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Previous Myocardial Infarction
Effect of Omega 3 Fatty Acids on Vascular Function
The mechanisms through which omega-3 fatty acids reduce adverse cardiac events remain uncertain. The aim of the study was to investigate the effect of omega-3 fatty acid supplementation on endothelial vasomotor function…
- Trial name
- NCT01888211
- Testing
- Omega 3 fatty acid supplementation, Olive Oil
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Vascular Diseases
Sevelamer, Fetuin-A and Endothelial Dysfunction in CKD
Vascular calcification and endothelial dysfunction (ED) contribute to the development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD).
- Trial name
- NCT00486772
- Testing
- Sevelamer (Renagel), calcium acetate (Phos-ex)
- Sponsor
- Gulhane School of Medicine
Diabetic Peripheral Vascular Disease
Measurement of Endothelial Function With Peripheral Arterial Tonometry in Patients Undergoing Hyperbaric Oxygen Therapy
The purpose of this clinical study is to test whether or not patients treated with HBOT for diabetic foot ulcers will demonstrate measurable changes of the blood vessel function during the course of HBOT treatments. , i.e.
- Trial name
- NCT02221466
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Ole Hyldegaard
Myocardial Infarction
Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention
Intracoronary abciximab administration during primary percutaneous coronary intervention (pPCI) could offer clinical advantages over the intravenous route.
- Trial name
- NCT01757457
- Testing
- Intracoronary administration of an abciximab bolus during primary PCI, Intravenous administration of an abciximab bolus during primary PCI
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Endothelial Dysfunction
Effects of Carbon Monoxide Breathing on Blood Vessel Function
In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah…
- Trial name
- NCT03067701
- Testing
- Carbon Monoxide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Hypertension
Black Garlic Nutraceuticals and Blood Pressure Control
Black garlic contains a series of allyl-sulfur compounds with the ability to modulate nitric oxide synthetase, angiotensin-converting enzyme system, and endothelial activation, which together could help better control blood…
- Trial name
- ENDOGARLIC (NCT04915053)
- Testing
- ABG+ Black Garlin, Crystalline Cellulose
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universitat de Lleida
Myocardial Infarction
Reducing Micro Vascular Dysfunction in Acute Myocardial Infarction by Ticagrelor
The current trial will compare the protective effect of ticagrelor and prasugrel on microvascular dysfunction in patients with revascularized ST elevation myocardial infarction.
- Trial name
- REDUCE-MVI (NCT02422888)
- Testing
- Ticagrelor, Prasugrel
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Amsterdam UMC, location VUmc
Choroidal Neovascularization (CNV)
Assess the Efficacy/Safety of Intravitreal Ranibizumab in Patients With Vision Loss Due to Choroidal Neovascularization.
This study was conducted to evaluate the efficacy and safety of 0.5 mg ranibizumab in adult and adolescent patients with visual impairment due to choridal neovascularization (CNV).
- Trial name
- NCT01840410
- Testing
- Ranibizumab
- Where
- 59 sites in Australia, Canada and 19 more
- Volunteers
- 183 people
- Sponsor
- Novartis Pharmaceuticals
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