Clinical trials: Vascular Function
Peripheral Arterial Disease
Maximal Exercise Capacity, Physical Activity and Respiratory Muscle Strength in Peripheral Artery Disease
The primary aim of the study is to evaluate the maximal and submaximal exercise capacity in patients with peripheral artery disease (PAD).
- Trial name
- NCT03458754
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cardiooncology, Myeloma
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs).
- Conditions
- Cardiooncology, Myeloma, Endothelial Dysfunction
- Trial name
- NCT03776331
- Testing
- Flow mediated dilation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Sleep Apnea, Insufficient Sleep Syndrome
Improving Outcomes for Patients With SDB and Insufficient Sleep
The purpose of this study is to look at how sleep disordered breathing (SDB) and not getting enough sleep each night contribute to daytime sleepiness.
- Conditions
- Sleep Apnea, Insufficient Sleep Syndrome, Sleep, Hypertension
- Trial name
- RESTORE (NCT04279834)
- Testing
- PAP Treatment, Sleep Education I
- Where
- United States
- Volunteers
- 561 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Aortic Dissection
Functional Study of Metabolites in Patients With Aortic Dissection
Research on metabolites in patients with aortic dissection, with a view to finding products with high or low metabolism in patients with aortic dissection, looking for metabolic factors related to the onset of aortic dissection…
- Trial name
- NCT04450433
- Testing
- aortic dissection and healthy people
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
COPD, Tetrahydrobiopterin Deficiency
O2 Transport and Utilization in Health and Lung Disease
Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood.
- Conditions
- COPD, Tetrahydrobiopterin Deficiency, Oxidative Stress
- Trial name
- NCT04014712
- Testing
- Tetrahydrobiopterin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Cardiovascular Risk Factor
Enhanced Vascular Function Following Intake of Feruloyl Esterase-processed High Fibre Bread.
This study evaluates the impact of a high phenolic acid intake from wholegrain wheat bread on human vascular function and plasma phenolic acid concentrations in healthy adults.
- Trial name
- NCT03946293
- Testing
- White Bread, Wholegrain bread, Wholegrain Enzyme
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Reading
Stroke, Hemiplegia
Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction
Upper limb paralysis following stroke is a very common problem. Only 30% of stroke patients who suffer from upper limb paresis experience a full recovery of function.
- Trial name
- VibMirror (NCT01010607)
- Testing
- Vibration and Mirror, Mirror therapy
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Functional Disability, Dementia
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is a post-treatment, longitudinal observational follow-up study of ASPREE participants. Although the ASPREE trial medication was ceased, the study activity was not stopped and ASPREE participants are continuing with…
- Conditions
- Functional Disability, Dementia, Heart Disease, Stroke
- Trial name
- NCT07224347
- Where
- 36 sites in United States, Australia
- Volunteers
- 19,114 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Cystic Fibrosis
Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Perhaps one of the most disturbing aspects of Cystic Fibrosis (CF) is the associated premature death. Oxidative stress has been observed in patients with CF and exercise intolerance has been shown to predict mortality in patients…
- Trial name
- NCT01772758
- Testing
- BH4 5mg, BH4 20mg, Antioxidant Cocktail
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Augusta University
Aging
The Effect of Bikram Yoga on Arterial Stiffness and Endothelial Function in Middle-Aged Adults
Arterial stiffening and endothelial dysfunction are correlates of advancing age contributing to the decline in cardioprotection with age.
- Trial name
- NCT02488148
- Testing
- Hot yoga, Non-heated yoga
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Edema, Varices; Cord
Effect of Intraoperative Taping on the Control of Edema Resulting From Stripping
The aim of the study is to evaluate the effects of the Contensive Taping technique on the control of edema of patients submitted to Phleboextraction Surgery including Saphenectomy.
- Trial name
- NCT05534308
- Testing
- Transoperative taping, No trasoperative taping
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Stroke
Transcranial Direct Current Stimulation and Functional Electrical Stimulation for Upper-limb Rehabilitation After Stroke
The aim of this study is to verify the effectiveness of tDCS combined with FES on upper limb rehabilitation of post-stroke subjects with moderate and severe compromise.
- Trial name
- NCT02818608
- Testing
- Functional Electrical Stimulation (FES), Combination of Transcranial direct brain stimulation (tDCS) and FES
- Where
- Brazil
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypertension, Elevated Blood Pressure
The Effects of Hot Yoga on Vascular Function
This study will examine the effects of a 12 week hot yoga intervention on vascular health in adults between the ages of 20 and 65.
- Trial name
- NCT03993184
- Testing
- Hot Yoga
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas State University
Intracranial Aneurysms
Intracranial Aneurysms and Cognitive Function
The prevalence rate of intracranial aneurysms in the adult population is close to 5%. Rupture risk of such aneurysms causing subarachnoid hemorrhage (SAH) can be substantial.Most patients suffering from an aneurysmal SAH are in…
- Trial name
- NCT01320306
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Atherosclerosis, Hypercholesterolemia
The Effect of Fasudil on Vascular Function in Humans
The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.
- Trial name
- NCT00120718
- Testing
- fasudil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vascular Diseases, Hypercholesterolemia
The Effect of Plant Sterols on Vascular Function
The main aim of the study is to investigate, in humans, the effect of plant sterols on vascular function by measuring flow-mediated dilation (FMD).
- Trial name
- NCT01803178
- Testing
- Plant Sterols
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Peripheral Arterial Disease
Functional MRI of the Lower Extremities
In this project, the investigators propose to use high-resolution magnetic resonance imaging (MRI) to measure blood perfusion in different groups of calf muscle.
- Trial name
- NCT03423316
- Testing
- Supervised exercise therapy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital