Clinical trials: Vascular Inflammation
Atrial Fibrillation, Arrhythmia
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age.
- Trial name
- NCT04766814
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tulane University
Insulin Resistance, Atherosclerosis
Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CT
People with diabetes are at increased risk for atherosclerosis and have high CVD morbidity and mortality rates. Tools for detecting and quantifying atherosclerotic pro/regression in people with diabetes and other CVD risk factors…
- Conditions
- Insulin Resistance, Atherosclerosis, Cardiovascular Disease, HIV/AIDS
- Trial name
- NCT00958815
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04066283
- Testing
- No intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases, Hypertension
Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans
The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood.
- Conditions
- Cardiovascular Diseases, Hypertension, Diet, Healthy
- Trial name
- NCT05344287
- Testing
- Typical American Diet, Plant-Based Diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Subclinical Atherosclerotic Cardiovascular Disease, Neurocognitive Decline
MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling
The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.
- Trial name
- MISTIC (NCT07520643)
- Testing
- Peripheral Vascular Imaging, Coro-CT, Neurocognitive Assesment
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atherosclerosis, Obesity
Vascular Inflammation Stratified by Body Size Phenotype
Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque Recently…
- Conditions
- Atherosclerosis, Obesity, Metabolic Syndrome
- Trial name
- NCT01979068
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Korea University
Cognition
The Effect of Pistachio-Rich Breakfast Meals on Cognitive Function in Healthy Older Adults
This study aims to investigate the effect of a breakfast meal containing varying serving sizes (doses) of pistachio nuts on cognitive function throughout the course of the day in healthy ageing adults aged 65-80.
- Trial name
- PACVAN (NCT06900452)
- Testing
- 0.5 serving of pistachios, 1 serving of pistachios, 2 servings of pistachios
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Reading
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Obesity, Vascular Dysfunction
DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for…
- Trial name
- NCT03527420
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Morbid Obesity
Sleeve-gastrectomy Efficacy in Morbid Obese Patient With a Focus on the Role of Inflammation
Despite the wide range of studies concerning the positive effects of bariatric surgery on metabolic state of morbid obese patient, it is necessary to further investigate the specific role of the "sleeve-gastrectomy" intervention…
- Trial name
- NCT03559842
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Obesity, Hypertriglyceridemia
Effects of Omega-3 Fatty Acids on Markers of Inflammation
The major purpose of this study is to examine the effect of two sources of dietary omega-3 fatty acids, each given at two doses, on potential health benefits related to cardiovascular disease prevention.
- Conditions
- Obesity, Hypertriglyceridemia, Insulin Resistance, Hypertension
- Trial name
- NCT01129050
- Testing
- Fish Oil, Flaxseed Oil
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Stanford University
Genetic Predisposition to Disease, Inflammation
Gene Expression in Chronic Venous Leg Ulcers
Chronic Venous Disease (CVD) is a widespread clinical condition widely spread in the western countries that may negatively impact the quality of life (QoL) of affected patients.
- Conditions
- Genetic Predisposition to Disease, Inflammation, Venous Leg Ulcer
- Trial name
- GECVELUS (NCT05134597)
- Testing
- Genetic assessment
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Hypercholesterolemia, Postmenopause
Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women
Estrogen therapy has been associated with reduced risk of coronary heart disease events in observational studies of postmenopausal women.
- Trial name
- NCT00001752
- Testing
- L-arginine, Estrogen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma, Hypersensitivity
Assessment of Lung Inflammation in Patients With Atopic Asthma Using Positron Emission Tomography
Asthma is a chronic inflammatory disease. We propose to study inflammatory changes in the lungs of subjects with atopic asthma of different severity in vivo using positron emission tomography (PET) with…
- Conditions
- Asthma, Hypersensitivity, Lung Diseases, Wegener's Granulomatosis
- Trial name
- NCT00001759
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atherosclerosis
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature
Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e.
- Trial name
- DEVA (NCT04098536)
- Testing
- Diesel exhaust
- Where
- 2 sites in Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Athens
Fabry Disease
FASHION Fabry Disease Hypertrophic Cardiomyopathy and Infammation
In Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) systemic inflammation recently gained attention as a possible key pathophysiologic process involved in the development of cardiac hypertrophy and progression of the…
- Trial name
- FASHION (NCT05761834)
- Testing
- Sample blood and 2D-echocardiography with Doppler
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiovascular Health
Pilot Study of Lychee Fruit Extract to Promote Cardiovascular Health
The investigators hypothesize that acute and short term consumption of a lychee fruit extract, particularly rich in low molecular weight dietary flavanols, will improve vascular function and reduce platelet reactivity.
- Trial name
- NCT01162213
- Testing
- Lychee Fruit Extract
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Heart Failure, Sudden Cardiac Death
Marathon, Genetics, Inflammation and the Cardiovascular System: MAGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with genotype/polymorphisms.
- Trial name
- MAGIC (NCT00845286)
- Testing
- Munich Marathon
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Periodontal Diseases
Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome
Emerging research indicates a link between polycystic ovary syndrome (PCOS) and periodontal diseases, revealing the intricate relationship between oral health and systemic conditions.
- Trial name
- NCT06184412
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana