Clinical trials: Vascular Insufficiency
End Stage Renal Disease (ESRD)
Multi-Site STARgraft (10401) Trial
This is a multi-site, single-blind with parallel group, randomized controlled trial of Healionics STARgraft (10401) vascular graft for hemodialysis access compared with a market-leading commercially available ePTFE vascular graft…
- Trial name
- NCT07557862
- Testing
- STARgraft (10401), Gore Propaten
- Where
- 7 sites in Brazil, Colombia
- Volunteers
- 111 people
- Sponsor
- Healionics Corporation
Acute Renal Failure, Kidney Disease
Prevention of Serious Adverse Events Following Angiography
The purpose of this research study is to compare the effectiveness of intravenous isotonic sodium bicarbonate with intravenous isotonic sodium chloride and oral N-acetylcysteine (NAC) with oral placebo for the prevention of…
- Conditions
- Acute Renal Failure, Kidney Disease, Coronary Artery Disease
- Trial name
- PRESERVE (NCT01467466)
- Testing
- IV isotonic saline, IV isotonic bicarbonate, N-acetylcysteine
- Where
- 54 sites in United States, Australia and 2 more
- Volunteers
- 5,177 people
- Sponsor
- VA Office of Research and Development
Aortic Stenosis, Aortic Regurgitation
Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease
To compare changes in Left Ventricular Mass (LVM) depending on each blood pressure regulation between the intensive care group and the usual care group for patients with hypertension accompanied by aortic valve disease and…
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Hypertension, LVM
- Trial name
- NCT03666351
- Testing
- Amlodipine 5mg, Losartan, Losartan and Amlodipine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
High Blood Pressure, Kidney Disease, Chronic
Health Literacy 3D Kidney Model Patient Education Trial
High blood pressure has a different rate effect on many minoritized individuals. African Americans, as a result of high blood pressure, are six times more likely to go through kidney failure compared to white counterparts.
- Trial name
- NCT06683573
- Testing
- 3D Kidney model, Standard medical treatment
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hilary L Surratt, PhD
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyperparathyroidism, Arterial Stiffness
Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism
Active parathyroid glands among renal dialysis patients contribute to calcified and hardened blood vessels. Such damage to the blood vessels, in turn, takes a significant toll in terms of cardiovascular disease.
- Trial name
- NCT01143987
- Testing
- Cinacalcet
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- Chinese University of Hong Kong
End Stage Renal Disease, Hypertension, Renal
Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated With Elevated Serum Homocysteine in Hemodialysis Patients.
The aim of the study is to evaluate the efficacy of L-methylfolate in combination with methylcobalamine in reducing homocysteine blood levels in hypertensive end-stage renal disease patients on regular hemodialysis and its…
- Trial name
- NCT05807711
- Testing
- L-Methyl Folate and methylcobalamine
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Alexandria University
Peripheral Arterial Disease, Renal Insufficiency
Ultra Low Iodine Loaded Spectral CT Angiography (CTA)
The objectives of this study are: Evaluation of ultra-low iodine load CTA protocols of the aorta and lower extremities. To investigate whether dual-layer in combination with with virtual monoenergetic imaging (VMI) allows for…
- Trial name
- NCT05488899
- Testing
- Half iodine Spectral CT, Standard iodine conventional CT
- Where
- Norway
- Volunteers
- 216 people
- Sponsor
- University Hospital, Akershus
Acute Kidney Injury, Hypoperfusion
The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from…
- Conditions
- Acute Kidney Injury, Hypoperfusion, Fluid Overload
- Trial name
- NCT04198168
- Testing
- IV crystalloid fluid bolus
- Where
- Denmark
- Volunteers
- 2 people
- Sponsor
- Aarhus University Hospital
Chest Pain, Stroke Acute
Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).
Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day.
- Conditions
- Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)
- Trial name
- TrIAje Project (NCT07247669)
- Where
- Spain
- Volunteers
- 5,000,000 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
This study is a prospective, non-randomized, multicenter, single-arm, clinical study to evaluate the performance, safety and efficacy of the GORE® VIABAHN® FORTEGRA Venous Stent (formerly known as GORE® VIAFORT Vascular Stent)…
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT05489588
- Testing
- GORE® VIAFORT Vascular Stent
- Where
- 24 sites in United States
- Volunteers
- 165 people
- Sponsor
- W.L.Gore & Associates
End Stage Renal Disease (ESRD), Chronic Kidney Disease Requiring Hemodialysis
Ultrasound Prediction of Successful Balloon Assisted AVF Maturation
An arteriovenous fistula (AVF) is created to allow for cleaning of the blood in patients with severe kidney disease. An artery and a vein are surgically connected, typically in the arm.
- Trial name
- NCT06771973
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Kidney Disease, Peritoneal Dialysis
Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients
INTRODUCTION Peritoneal dialysis (PD) is a life-saving treatment for end-stage renal disease patients. However, cardiovascular disease remains the major cause of morbidity and mortality in PD patients.
- Trial name
- NCT02168283
- Testing
- treatment arm, Control arm
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Kidney Failure, Chronic
Arteriovenous Fistula Tissue Bank for Pre- and Post-Fistula Placement Specimens
This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.
- Trial name
- NCT00836862
- Testing
- Biologic specimens
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Nebraska
Venous Insufficiency
Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency
Clinical non-inferiority study between Diosmin 600 mg tablets and Diosmin 900 mg + Hesperidin 100 mg tablets in symptomatic chronic venous insufficiency after 6 months of treatment.
- Trial name
- NCT03471910
- Testing
- Diosmin, Diosmin / Hesperidin
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Fundação Educacional Serra dos Órgãos
Venous Insufficiency, Venous Reflux
Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers
This trial is a prospective, randomized, controlled, multi-center study of subjects presenting with chronic lower extremity venous ulcers.
- Conditions
- Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
- Trial name
- NCT01549860
- Testing
- MIST Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Celleration, Inc.
Cardiovascular Diseases, Hypertension
Uppsala Self-Screening of Cardiovascular Health
U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can…
- Conditions
- Cardiovascular Diseases, Hypertension, Dyslipidemias, Diabetes Mellitus
- Trial name
- U-SCREEN (NCT07614659)
- Testing
- Home-based multimodal cardiovascular screening
- Where
- Sweden
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Johan Sundström
Acute Kidney Injury Cardiac Surgery, Postoperative Complications
Vascular Aging and Acute Kidney Injury After Cardiac Surgery
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Conditions
- Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging
- Trial name
- NCT07727772
- Testing
- Multidimensional Vascular Aging Assessment
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Deep Venous Thrombosis, Post-thrombotic Syndrome
Novel PET/CT and Treatment Strategies to Reduce PTS Following DVT
The goal of this study is to develop strategies that will improve outcomes for patients with deep vein thrombosis (DVT), using in vivo FDG-PET inflammation imaging to better predict the development of the post-thrombotic syndrome…
- Trial name
- NCT03195777
- Testing
- PET/CT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Stasis Dermatitis
Study Evaluating Efficacy and Safety of Crisaborole in Adults With Stasis Dermatitis
This is a Phase 2a, randomized, double blind, vehicle controlled, parallel group, proof of concept study that will include participants with stasis dermatitis without active skin ulceration, who will receive crisaborole ointment…
- Trial name
- NCT04091087
- Testing
- crisaborole ointment, vehicle ointment
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- Pfizer
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