Clinical trials: Vascular Ischemia
Acute Coronary Syndrome
Soluble Receptors for Advanced Glycation End-Products and PCI
It is hypothesized that patients with low pre-PCI serum levels of sRAGE should receive DES implantation and/ or procedures taken to increase serum levels of sRAGE and/ or decrease the serum levels of AGE.
- Trial name
- NCT01867034
- Testing
- Drug Eluting Stent, Bare Metal Stent
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Saskatchewan
Ischemic Stroke
Clopidogrel Versus Cilostazol in Ischemic Stroke
Along with the current clinical trial, the efficacy and safety of a 300 mg loading dose of clopidogrel administered within 24 hours of the first-ever moderate to severe ischemic stroke compared to 200 mg cilostazol were assessed…
- Trial name
- NCT06242132
- Testing
- Clopidogrel tablet, Cilostazol 100 MG
- Where
- Egypt
- Volunteers
- 870 people
- Sponsor
- Kafrelsheikh University
Coronary Disease
Impact of Mobile Health in Improving Lifestyle and Therapeutic Adherence in Coronary Heart Disease
Cardiovascular diseases are the leading cause of death worldwide. In high-income countries, approximately seventy percent of cardiovascular diseases cases are attributable to modifiable risk factors, with metabolic risk factors…
- Trial name
- eMOTIVA (NCT05247606)
- Testing
- Mobile application
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- University of Cadiz
Ischemic Stroke, Embolic Stroke of Undetermined Source
SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation
Patent foramen ovale (PFO) is an important mechanism of embolic stroke of undetermined source (ESUS). Current guidelines recommend PFO closure for high-risk PFO in patients younger than 60 years, and a recent retrospective cohort…
- Conditions
- Ischemic Stroke, Embolic Stroke of Undetermined Source, Patent Foramen Ovale (PFO), Elderly
- Trial name
- SENIOR (NCT07479147)
- Testing
- PFO closure, Medication
- Where
- 3 sites in Taiwan
- Volunteers
- 400 people
- Sponsor
- Taichung Veterans General Hospital
Coronary Artery Disease
PITT PCI Xience Registry
Stents are devices utilized to treat cholesterol blockages of the coronary (heart) arteries. The introduction of drug-eluting (coated) stents into clinical practice is regarded as a revolutionary breaktrhough, as it has reduced…
- Trial name
- NCT01299207
- Where
- United States
- Volunteers
- 2,506 people
- Sponsor
- University of Pittsburgh
Coronary Arteriosclerosis, Cardiovascular Diseases
Pooling of Cohort Studies on Diet & Coronary Disease
To quantify the role of dietary factors in the etiology of coronary heart disease by pooling data from 10 major prospective studies on diet and coronary heart disease.
- Conditions
- Coronary Arteriosclerosis, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00006309
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Heart Disease
Evaluation of Integrated Cardiac Imaging in Ischemic Heart Disease
Main purpose of the study: To comparatively assess the diagnostic performance of non invasive anatomical and functional imaging modalities to detect significant obstructive coronary artery disease as demonstrated at invasive…
- Trial name
- EVINCI (NCT00979199)
- Testing
- Non invasive cardiac imaging
- Where
- 16 sites in Finland, France and 7 more
- Volunteers
- 697 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Stroke, Ischemic Stroke
Dietary Intervention With the Modified Atkins Diet in Stroke Rehabilitation
This phase 1 study tests whether use of the Modified Atkins Diet (MAD) can improve motor impairment after stroke. It is based on the hypothesis that after stroke, the brain's utilization of glucose, it's primary source of energy…
- Trial name
- NCT01820663
- Testing
- Modified Atkins Diet, Control diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Burke Rehabilitation Hospital
Myocardial Infarction
Firibastat or Ramipril After Acute Myocardial Infarction for Prevention of Left Ventricular Dysfunction
This is a multicenter, randomized, double-blind, active-controlled, dose-titrating phase 2 study to evaluate the safety and efficacy of firibastat administered orally BID (2 daily doses) versus ramipril administered orally BID…
- Trial name
- QUORUM (NCT03715998)
- Testing
- Ramipril, Firibastat
- Where
- 7 sites in France, Germany and 5 more
- Volunteers
- 295 people
- Sponsor
- Quantum Genomics SA
Coronary Chronic Total Occlusions, Ischemic Heart Disease
Acolyte CTO-PCI Study: Imaging and Catheter System to Treat Patients With Coronary Chronic Total Occlusion, Who Have Persistent Symptoms Following Medical Therapy and Are Undergoing Percutaneous Coronary Interventional Procedures
This is a study to evaluate the safety and effectiveness of the Acolyte Catheter System used in CTO-PCI procedures. The system will be used for the placement and positioning of guidewires and catheters in the coronary vasculature…
- Conditions
- Coronary Chronic Total Occlusions, Ischemic Heart Disease, Ischemic Heart Disease (IHD), Ischemic Heart Disease Chronic
- Trial name
- NCT06795763
- Testing
- CTO-PCI Procedure with Acolyte Catheter System
- Where
- 5 sites in United States
- Volunteers
- 115 people
- Sponsor
- Elumn8 Medical
Ischemic Stroke, Transient Ischemic Attack
Ticagrelor Based De-Escalation of Dual Antiplatelet Therapy in Ischemic Stroke
This is a randomized, controlled, outcome assessor blind, parallel group design pilot study on 100 patient with diagnosis of ischemic stroke admitted in Bou-Ali Sina Hospital, Sari,Iran.The aim of study is to compare the efficacy…
- Trial name
- DEDAPT-TICA (NCT06653348)
- Testing
- Ticagrelor 60 + Aspirin, Ticagrelor 90 + aspirin
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mazandaran University of Medical Sciences
Coronary Disease
Reduced Manipulation of the Aorta and Neurobehavioral Outcome Trial
The purpose of this trial is to determine whether aortic manipulation in patients undergoing coronary bypass graft surgery leads to increased incidence of microemboli and subsequent impairment of neurobehavioral function.
- Trial name
- NCT00059319
- Testing
- single aorta clamp with retrograde cardioplegia, multiple aorta clamps with antegrade cardioplegia
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Evaluation of Tissue Perfusion in Peripheral Arterial Disease (EVTI-PAD)
In this prospective single-center observational study, arterial perfusion in patients with lower limb peripheral arterial disease will be assessed with standard diagnostic tools (toe pressure, trans-cutaneous oxygen pressure…
- Conditions
- Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Critical Limb Ischemia
- Trial name
- EVTI-PAD (NCT05570019)
- Testing
- Revascularization
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University Innsbruck
Coronary Artery Disease
Efficacy of Automated Distal Vascular Anastomosis in Coronary Surgery: Phase II
This evaluation is designed to evaluate the feasibility of using an automated distal coronary anastomotic to facilitate grafting of the left internal mammary artery to the left anterio descending coronary artery during myocardial…
- Trial name
- NCT00292500
- Testing
- Automated distal anastomotic device
- Where
- Germany
- Volunteers
- 170 people
- Sponsor
- Cardica, Inc
Carotid Artery Diseases, Coronary Artery Disease
Outcome of LA Versus GA for Staged CEA Prior To CABG
A retrospective analysis of all patients that underwent carotid endarterectomy (CEA) for stenotic disease - diagnosed at pre-operative investigation - prior to CABG as staged operation within 6- months.
- Conditions
- Carotid Artery Diseases, Coronary Artery Disease, Stroke
- Trial name
- NCT04901000
- Testing
- Carotid endarterectomy
- Volunteers
- 44 people
- Sponsor
- Thomas Aherne
Cardiovascular Diseases, Heart Diseases
Race and the Use of Cardiovascular Surgical Procedures
To study the causes of persistent differences in Black-white access to tertiary care cardiovascular surgical services (TCCS).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005507
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Disease
BVS-OCT Imaging Study
The single center retrospective study evaluates the acute and long term outcomes of bioabsorbable drug-eluting scaffolds (BVS) implantation in 50 consecutive coronary artery disease (CAD) patients using optical coherence…
- Trial name
- NCT03194711
- Testing
- BVS implantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack
Comparison of Eversion and Conventional Techniques in Carotid Endarterectomy
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent…
- Conditions
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- Trial name
- NCT07288164
- Testing
- Carotid endarterectomy, conventional, Carotid endarterectomy, eversion
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Kastamonu University
Ischemic Stroke
Improving Neuroprotective Strategy for Ischemic Stroke With Poor Recanalization After Thrombectomy by Intra-arterial TNK (INSIST-TNK)
In 2015, five randomized trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischemic stroke caused by occlusion of arteries of the proximal anterior circulation.
- Trial name
- NCT04201964
- Testing
- Intra-arterial administration of tenecteplase
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Acute Coronary Syndrome (ACS)
Platelet Function in Patients With an Acute Coronary Syndrome
The aims of the study are to: explore whether platelet reactivity in patients treated wih novel platelet inhibitors is associated with clinical outcome investigate whether a therapeutic window exist for novel platelet inhibitors…
- Trial name
- ATLANTIS-ACS (NCT01992484)
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Vienna