Clinical trials: Vascular Liver Disease
Metabolomics
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome Radical Resection of Colorectal Cancer
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with colorectal cancer complicated with metabolic syndrome…
- Trial name
- NCT06710314
- Testing
- Colorectal cancer patients with hypertension, Colorectal cancer patients with diabetes, Colorectal cancer patients with fatty liver
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Dong Peng
Veno-occlusive Disease
Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients
This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric…
- Trial name
- NCT02851407
- Testing
- Defibrotide, Best Supportive Care
- Where
- 114 sites in United States, Australia and 12 more
- Volunteers
- 372 people
- Sponsor
- Jazz Pharmaceuticals
Liver Transplant; Complications, Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient
Ischemia and reperfusion injury is unavoidable during a liver transplantation. Remote ischemic preconditioning, a safe and feasible method, has previously been shown to reduce ischemia and reperfusion injury.
- Trial name
- NCT03758352
- Testing
- remote ischemic preconditioning (rIC), non remote ischemic preconditioning (non-rIC)
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Cirrhosis
Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver Cirrhosis
The aim of this study is to investigate the pharmacokinetic and pharmacodynamic parameters of rivaroxaban and apixaban in patients with compensated liver cirrhosis (Child-Pugh class A and B).
- Trial name
- NCT04874428
- Testing
- Rivaroxaban 10 mg Oral Tablet, Apixaban 2.5 mg Oral Tablet
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Liver Cirrhosis, Coagulation Disorder
Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes
Rifaximin is an antibiotic that acts locally in the gastrointestinal tract with a broad spectrum of antibacterial activity. The efficacy of rifaximin is well documented in the prevention of acute hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Coagulation Disorder, Platelet Disorder, Endotoxemia
- Trial name
- NCT06630572
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Coagulation Disorder, Cirrhosis, Liver
Heparin Like Effect in Acute Variceal Bleeding
This study attempts to clarify the pathophysiology of haemostasis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these patients.
- Conditions
- Coagulation Disorder, Cirrhosis, Liver, Variceal Hemorrhage
- Trial name
- NCT04111120
- Testing
- SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Liver Diseases, Intra-Abdominal Hypertension
Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation
Patients with end stage liver disease have varying degrees of intra-abdominal hypertension (IAH) due to the presence of ascites. The perioperative events may either relieve or aggravate the intra-abdominal pressures.
- Conditions
- Liver Diseases, Intra-Abdominal Hypertension, Cirrhosis, Liver, Organ Dysfunction Syndrome
- Trial name
- OIL (NCT04463745)
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatic Angiosarcoma
Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation
Cytological diagnosis of hepatic angiosarcoma by fine-needle aspiration (FNA) or imprint cytology is difficult due not only to its various cytomorphologic features but also clinical rarity.
- Trial name
- NCT03025438
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Cystic Fibrosis, Immunologic Deficiency Syndrome
Natural History of Noncirrhotic Portal Hypertension
Background: Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. It seems to start slowly and not have many warning signs.
- Conditions
- Cystic Fibrosis, Immunologic Deficiency Syndrome, Turner Syndrome, Congenital Hepatic Fibrosis
- Trial name
- NCT02417740
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ischemic Reperfusion Injury, Liver Injury
Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury
Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local…
- Conditions
- Ischemic Reperfusion Injury, Liver Injury, Cancer Recurrence, Malignancy
- Trial name
- annie-liver (NCT04257240)
- Testing
- selective hepatic vascular exclusion, semielective hepatic vascular exclusion
- Volunteers
- 230 people
- Sponsor
- Aretaieion University Hospital
Liver Tumors
Safety and Clinical Efficacy of Histotripsy for Liver Cancers Adjacent to Major Intrahepatic Vessels
Malignant liver tumors are among the most common malignancies worldwide, with over 10,000 new cases diagnosed annually in Taiwan.
- Trial name
- NCT07063771
- Testing
- Histotripsy
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Obesity, Colon Cancer
Proteomic Analysis of Patients Undergoing Bariatric Surgery
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery.
- Conditions
- Obesity, Colon Cancer, Thyroid Cancer, Esophageal Cancer
- Trial name
- NCT06787807
- Testing
- bariatric surgery
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Hepatocellular Carcinoma
Recurrence and Distant Metastases in Hepatocellular Carcinoma Treated by Transcatheter Arterial Chemoembolization
This project will include at least 40 patients with hepatocellular carcinoma (HCC) who will receive transcatheter arterial chemoembolization (TACE) as a sole method for the management.
- Trial name
- NCT00834028
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hepatocellular Carcinoma
Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma
Bleeding is a major problem during liver resection. Vascular inflow occlusion, also known as Pringle maneuver, has been commonly employed to reduce blood loss during liver surgery.
- Trial name
- NCT01759901
- Testing
- Pringle
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Severe Hepatic Veno-Occlusive Disease
Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients
The purpose of this study is to (1) demonstrate the efficacy and safety (toxicity) of 25 mg/kg/day of Defibrotide in patients with severe veno-occlusive disease (sVOD) and (2) evaluate serum and endothelial markers of…
- Trial name
- NCT00358501
- Testing
- Defibrotide
- Where
- 25 sites in United States, Canada
- Volunteers
- 134 people
- Sponsor
- Jazz Pharmaceuticals
Liver Cirrhosis, Gastric Antral Vascular Ectasia
Thalidomide Versus Argon Plasma Coagulation in Gastric Antral Vascular Ectasia(GAVE)-Related Anaemia in Cirrhosis (TAG Trial)
Gastric Antral Vascular Ectasia (GAVE) is an erosive form of gastritis distinguished by veno-capillary ectasia, which manifests as tortuous columns of dilated vessels.
- Trial name
- NCT06772480
- Testing
- Thalidomide, Argon Plasma Coagulation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Diabetes, Metabolic Disorders
Observational Study for the Characterisation of Patients Affected by Any Type of Diabetes and Endocrine Disorders
The main objective of this retrospective and prospective observational register is to identify anthropometric, clinical, laboratory and/or instrumental markers of disease severity and activity in patients suffering from diabetes…
- Conditions
- Diabetes, Metabolic Disorders, Arterial Hypertension, Dyslipidemia
- Trial name
- DiabRegistry (NCT07206875)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Type2 Diabetes, Nonalcoholic Steatohepatitis
A Reduced-carbohydrate Diet High in Monounsaturated Fats in Type 2 Diabetes
Further studies are needed to establish the optimal diet for treating T2D. The investigators wishes to investigate whether a low carbohydrate diet, high in monounsaturated fats (LCD) will affect cardiovascular function…
- Conditions
- Type2 Diabetes, Nonalcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease, Atherosclerosis
- Trial name
- ReDuCtion (NCT03068078)
- Testing
- Low carbohydrate diet high in monounsaturated fats
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- Odense University Hospital
Liver Diseases, Reperfusion Injury
Effect Inhaled Nitric Oxide in Adult Liver Transplant
Liver transplantation remains the only cure for patients with end-stage liver disease. Despite continuous advances in medical care, ischemia-reperfusion injury (IRI) (tissue damage that occurs when blood supply is restored to an…
- Conditions
- Liver Diseases, Reperfusion Injury, Vasoplegia
- Trial name
- NCT07125443
- Testing
- Prospective iNO Administration ("After" Group), No Intervention Retrospective "Before" Group
- Volunteers
- 260 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's