Clinical trials: Vascular Neurocognitive Disorder
Stroke, Acute, Swallowing Disorder
Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE
Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited.
- Conditions
- Stroke, Acute, Swallowing Disorder, Cognitive Impairment, Stroke
- Trial name
- NCT06288243
- Testing
- Clinician-observed assessment tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Medipol University
Ischemic Stroke, Cognitive Impairment
Early Neuropsychological Rehabilitation and Family Psychoeducation After Ischemic Stroke
Cognitive impairment and reduced quality of life are frequent consequences of ischemic stroke and can also affect family caregivers, who often assume caregiving responsibilities with limited preparation.
- Conditions
- Ischemic Stroke, Cognitive Impairment, Quality of Life, Caregiver Burden
- Trial name
- NCT07793682
- Testing
- Computerized neuropsychological rehabilitation, Family psychoeducational program, Non-specific recreational cognitive activities / active digital control
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Vascular Dementia
Rivastigmine Capsules in Patients With Probable Vascular Dementia
The goal of this research study is to evaluate, in the open-label extension phase, the effectiveness, tolerability and safety of rivastigmine capsules in males and females between the ages of 50 and 85 years old with probable…
- Trial name
- NCT00130338
- Testing
- Rivastigmine
- Volunteers
- 521 people
- Sponsor
- Novartis
Diabetes, Cancer
Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures
Explore the benefit of the game-based virtual reality system in improving lower extremity kinematics and balance in patients suffering from disease/disorders including Diabetes, Cancer, Multiple Sclerosis, Arthritis, Parkinson's…
- Conditions
- Diabetes, Cancer, Multiple Sclerosis, Arthritis
- Trial name
- NCT02777060
- Testing
- Exergame, Home based balance training
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Postoperative Cognitive Dysfunction, Cerebrovascular Accident
Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft
Primary objectives: Assessment of the incidence of postoperative cognitive dysfunction (POCD), cerebrovascular accident (CVA), and delirium after minimal invasive coronary artery bypass grafting (Endo-CABG).
- Conditions
- Postoperative Cognitive Dysfunction, Cerebrovascular Accident, Delirium
- Trial name
- NOMICS (NCT02979782)
- Testing
- Endo-CABG, PCI
- Where
- 2 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
Prodromal Alzheimer's Disease, Cerebral Vascular Disorder
Hyperbaric Oxygen Therapy for Prodromal Alzheimer´s Disease With Cerebrovascular Disease
Alzheimer´s disease is a devastating illness that effects the patients as well as their family members. Its prevalence increases exponentially and the burden on the healthcare system is enormous.
- Conditions
- Prodromal Alzheimer's Disease, Cerebral Vascular Disorder, Mild Cognitive Impairment, Vascular Cognitive Impairment
- Trial name
- NCT05349318
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Stroke, Cognitive Decline
Efficacy and Safety of Immersive Virtual Reality for Post-stroke Cognitive Impairment
This is a single-blind randomized controlled trial to evaluate the efficacy and safety of immersive virtual reality for post-stroke cognitive impairment.
- Trial name
- EVRPSC (NCT06704360)
- Testing
- immersive VR pathfinding training, Occupational therapy
- Volunteers
- 40 people
- Sponsor
- Dingqun Bai
Delirium, Pain
Pregabalin in the Prevention of Postoperative Delirium and Pain
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves…
- Trial name
- NCT00819988
- Testing
- Pregabalin, Sugar pill
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
Alzheimer's Disease, Dementia
Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia
The objective of the study is to define the performance of blood-based signatures for Alzheimer's Disease (AD) in different patients populations including AD, non-AD dementia, and non-demented controls.
- Trial name
- NCT00880347
- Testing
- Blood sampling
- Where
- 21 sites in France
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Exonhit
Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive and Physical Home-rehabilitation by Information and Communications Technology. Games for Older Adults Active Life (GOAL)
Aging is often associated with pathological pathway such as in Mild Cognitive Impairment (MCI), and that pathway may be associated to a high risk of dementia.
- Conditions
- Cognitive Dysfunction, Mild Cognitive Impairment, Vascular Cognitive Impairment
- Trial name
- GOAL (NCT03383549)
- Testing
- Tele-rehabilitation
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dementia, Cardiovascular Risk Factor
Cerebrovascular Correlates of Dementia in Rural Communities - The Three Villages Study
This study aims to assess the prevalence and severity of dementia in an established cohort of community-dwelling older adults living in three neighboring rural Ecuadorian villages (Atahualpa, El Tambo, and Prosperidad), as well…
- Conditions
- Dementia, Cardiovascular Risk Factor, Atherosclerosis, Cerebral Small Vessel Diseases
- Trial name
- NCT04123171
- Testing
- Neuroimaging studies
- Where
- 2 sites in Ecuador
- Volunteers
- 600 people
- Sponsor
- Universidad de Especialidades Espiritu Santo
Stroke
Effects of Mobile Application-Based Cognitive Training Along With Aerobic Training
This randomized controlled trial will determine the effects of combining mobile application-based cognitive training with aerobic exercise on cognitive function and the effects of combining mobile application-based cognitive…
- Trial name
- NCT07148453
- Testing
- Experimental Group, Control Group
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Cognitive Impairment
Compensatory and Restorative Rehabilitation Techniques in Stroke
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
- Trial name
- NCT06325085
- Testing
- compensatory and restorative rehabilitation techniques, Traditional cognitive rehabilitation training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Multiple Myeloma (MM), CART Therapy
Neurocognitive Trajectories After BCMA CAR-T
The purpose of this research study is to evaluate cognitive changes over time in participants with relapsed or refractory multiple myeloma who have received chimeric antigen receptor T-cell therapy (CAR-T).
- Conditions
- Multiple Myeloma (MM), CART Therapy, Refractory Multiple Myeloma (RRMM)
- Trial name
- CAR-T Cog (NCT07740317)
- Testing
- Standardized neurocognitive testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular Diseases, Mortality
Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment.
- Conditions
- Cardiovascular Diseases, Mortality, Type 2 Diabetes Mellitus, Cognitive Decline
- Trial name
- NCT03192410
- Testing
- Dietary intake, Lifestyle factors, Blood biomarkers
- Where
- Netherlands
- Volunteers
- 4,837 people
- Sponsor
- Wageningen University
Coronary Artery Disease, Cognitive Impairment
Cerebral Oxygenation and Neurological Functioning After Cardiac Surgery
The overall goal of this research program is to determine quantitative predictors of quantitative long-term neurological functioning following different cardiac surgery procedures.
- Conditions
- Coronary Artery Disease, Cognitive Impairment, Delirium
- Trial name
- CONFUSE (NCT04081649)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Dr. Gordon Boyd
Low Blood Pressure, Delirium
Vasopressor SAT Study
To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean…
- Conditions
- Low Blood Pressure, Delirium, Critical Illness
- Trial name
- NCT03182335
- Testing
- sedation awakening trial
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Age-related Cerebral White Matter Changes, Cognition Disorder
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study
To evaluate the dose-response of relevant blood biomarkers to remote ischemic conditioning in patients with age-related cerebral white matter hyperintensities on MRI, in preparation for a subsequent larger efficacy trial.
- Trial name
- NCT06179797
- Testing
- remote ischemic conditioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Augusta University