Clinical trials: Vascular Neurocognitive Disorder
Mild Dementia, Mild Cognitive Impairment
The Swedish BioFINDER - Memory Clinic Study
The diagnosis of diseases causing memory difficulties or dementia is often challenging. Without the use of advanced methods such as cerebrospinal fluid tests, approximately 25-30% do not receive a correct diagnosis today.
- Conditions
- Mild Dementia, Mild Cognitive Impairment, SCD, Alzheimer Disease
- Trial name
- Validate (NCT06122415)
- Testing
- Plasma Amyloid Probability Score 2 (APS 2) score, Plasma ptau217/nptau217, Plasma ptau217
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Skane University Hospital
Coronary Artery Disease, Sleep Quality
Effect of Eye Mask Use on Sleep Quality and Delirium After CABG Surgery
Coronary artery bypass graft (CABG) surgery is an effective treatment for coronary artery disease; however, sleep disturbances and delirium are common during the postoperative period and may adversely affect recovery.
- Conditions
- Coronary Artery Disease, Sleep Quality, Postoperative Delirium (POD)
- Trial name
- EYE-CABG (NCT07768020)
- Testing
- Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Munzur University
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Short-Term and Long-Term Cognitive Outcomes in Adults After Cardiac Surgery
Adults with coronary artery disease (250 patients) undergoing cardiac surgery participated in the study. The aim is to investigate short-term and long-term cognitive outcomes and the patterns of organization of functional brain…
- Trial name
- NCT05172362
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Stroke
Physical Performance and Cognitive Functions in Patients With Chronic Stroke
This study aims to investigate the impact of cognitive impairment on upper extremity physical performance, cognitive skills, and functional independence in individuals with chronic stroke.
- Trial name
- NCT07887776
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Kutahya Health Sciences University
Neurological Disorder
Multidisciplinary Lifestyle Interventions for Neurological Disorders During the Silent Phase
This clinical trial aims to test the impact of multidisciplinary lifestyle interventions (MLI) in neurologically healthy but at-risk individuals.
- Trial name
- MINDS (NCT05984056)
- Testing
- Multidisciplinary lifestyle interventions
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vineet Punia MD
Obstructive Sleep Apnea
Ambulatory Blood Pressure Control and Cognition in Patients With Obstructive Sleep Apnea (AMPLE)
To compare the blood pressure control and cognitive responses of three groups of patients: those diagnosed with Obstructive Sleep Apnea (OSA) and treated with Continuous Positive Airway Pressure (CPAP) for at least six months…
- Trial name
- AMPLE (NCT06463002)
- Testing
- Ambulatory blood pressure monitoring and Montreal Cognitive Assessment
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Dementia Alzheimer Type, Dementia Associated With Cerebrovascular Disease
Rifaximin SSD in Dementia Trial
Using a new formulation of rifaximin, a non-absorbable antibiotic, to test if it can affect microbes in the gut of patients with dementia favorably.
- Trial name
- RIDE (NCT06718686)
- Testing
- Rifaximin SSD 40 mg IR tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jasmohan Bajaj
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
Ischemic Stroke, Consciousness Disorder
Transcranial Magnetic Stimulation in Disorder of Consciousness in Acute Severe Cerebrovascular Disease Patients
This study is aimed at evaluating the potential of transcranial magnetic stimulation in patients with acute severe ischemic stroke with DoC while assessing patients with a hybrid neural network evaluation model.
- Conditions
- Ischemic Stroke, Consciousness Disorder, Transcranial Magnetic Stimulation
- Trial name
- I-HELP (NCT05670873)
- Testing
- Transcranial magnetic stimulation
- Volunteers
- 50 people
- Sponsor
- Liping Liu
Ischemic Stroke, Cognitive Impairment
Cognitive Impairment and Outcome of Acute Ischemic Stroke.
The aim of this study is to assess the use of ASPECTS and stroke biomarkers to predict the outcome and cognitive impairment in acute ischemic stroke.
- Conditions
- Ischemic Stroke, Cognitive Impairment, Outcome, Fatal
- Trial name
- NCT04235920
- Testing
- Montreal Cognitive Assessment (MoCA)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Head Trauma, Head Injury
Delayed IntraCranial Hemorrhage in Oral AntiCoagulant Treated Patients With Mild Traumatic Brain Injury
As a low quality, weak recommendation, it is part of the Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults, that patient with a GCS of 14-15 and anticoagulation therapy and a…
- Conditions
- Head Trauma, Head Injury, Delirium, Thrombosis
- Trial name
- dICH-OAC (NCT07195760)
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Stroke, Cognitive Impairment
Tele-Rehabilitation vs Conventional Rehabilitation for Cognitive Improvement in Stroke Survivors.
This study aims to: Compare tele-rehabilitation and conventional rehabilitation for cognitive improvement after stroke. Evaluate changes in cognitive function using standardized assessment tools.
- Conditions
- Stroke, Cognitive Impairment, Post-Stroke Cognitive Impairment
- Trial name
- NCT07504276
- Testing
- Tele-rehabilitation, Conventional Rehabilitation
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Hypertension
One Research on Improving Cognitive Impairment Caused by Hypertension
Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive impairment caused by hypertension.
- Trial name
- NCT03943420
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Moyamoya Disease, Revascularization
The Evolution and Prognosis of Moyamoya Disease
To investigate the evolution of imaging appearances and cognitive function of Moyamoya disease (MMD) and to establish a prognosis evaluation system based on imaging biomarkers in MMD.
- Conditions
- Moyamoya Disease, Revascularization, Cognitive Impairment, Functional Impairment
- Trial name
- NCT05619068
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Alzheimer Disease, Mild Cognitive Impairment
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders
The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia With Lewy Bodies, Dementia, Vascular
- Trial name
- RHAPSODY (NCT04939818)
- Where
- 2 sites in United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Atherosclerosis, Cognitive Decline
Advancing Postmenopausal Preventive Therapy
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical…
- Trial name
- APPT (NCT04103476)
- Testing
- Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cardiac Diseases, Stroke
DanceFit Prime: A Dance Based Physical Activity and Nutritional Intervention for Primary Care - A Feasibility Study
Regular physical activity improves physical and mental health and reduces the risk of heart disease, stroke, cancer, diabetes, obesity and premature death from any cause.
- Conditions
- Cardiac Diseases, Stroke, Diabetes Mellitus, Dementia
- Trial name
- DanceFit (NCT02159014)
- Testing
- Facilitated group-based aerobic dance, Online, video prompted, individual aerobic dance, Facilitated group-based nutritional intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- North Essex Partnership NHS Foundation Trust
Vascular Disease
Is Peri-operative Hyperoxemia a Risk Factor for Postoperative Complications?
Patients undergoing vascular surgery are at a significantly high risk of perioperative cardiovascular, cerebral and renal events compared to those undergoing non-vascular surgery.
- Trial name
- HYPEROXIA (NCT02562781)
- Testing
- Oxygen, Air
- Where
- 2 sites in Sweden
- Volunteers
- 184 people
- Sponsor
- Örebro University, Sweden
Human Immunodeficiency Virus, Neurocognitive Impairment
Brain Imaging for HIV-Associated Thinking and Mood Disorders
Background: Human immunodeficiency virus (HIV) infection appears to cause problems with blood vessel function. These problems may add to some thinking and mood disorders found in people with HIV infection.
- Trial name
- NCT01692236
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)