Clinical trials: Vascular Neurocognitive Disorder
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Aphasia, Acquired, Language Disorders
Enhancing Language Function in Aphasia
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain).
- Conditions
- Aphasia, Acquired, Language Disorders, Primary Progressive Aphasia, Stroke, Cerebrovascular
- Trial name
- NCT05443633
- Testing
- individualized speech-language training, standard language intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Dementia, Alzheimer Disease
Learning and Coping With Early Stage Dementia
The overall aim of this study is to investigate how home dwelling people with early-stage dementia cope with their disease, explored through their participation in a 12-week health promotion course, through 3 sub-studies; 1) The…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT03741543
- Testing
- A 12-week health promotion course
- Volunteers
- 108 people
- Sponsor
- Helse Stavanger HF
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Alzheimer's Disease (AD), Alzheimer's Disease (AD) Related Disorders
MEMENTO-VAScular COmponents of Dementia
A Multicenter national longitudinal cohort study including at least 800 individuals recruited from French Research Memory Centers and followed up over 36 months and included in Memento.
- Trial name
- VASCOD (NCT02264899)
- Testing
- in Memento-VASCOD
- Where
- 10 sites in France
- Volunteers
- 332 people
- Sponsor
- University Hospital, Bordeaux
Obesity, Vascular Dementia
Urolithin A Supplementation in Middle-aged Adults With Obesity
The goal of this clinical trial is to learn about the effect of urolithin A, a dietary supplement, on blood flow in middle-aged adults with obesity.
- Conditions
- Obesity, Vascular Dementia, Cognitive Impairment
- Trial name
- NCT05921266
- Testing
- Urolithin A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Cardiac Surgery
Non-pharmacologial, Non-invassive Intervention Before Cardiac Surgery: a Randomized Controlled Trial
Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability.
- Trial name
- NICE (NCT06791551)
- Testing
- active RIPC and tDCS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Carotid Stenosis, Cognitive Impairment
Cognitive Improvement After Carotid Stenting in Hyperbaric Oxygen Therapy Trial
The purpose of CARE-HBOT study is to evaluate whether patients with symptomatic severe carotid artery stenosis with cognitive impairment who underwent hyperbaric oxygen therapy plus standard medical treatment after stent…
- Conditions
- Carotid Stenosis, Cognitive Impairment, Hyperbaric Oxygen Therapy, Stent Implantation
- Trial name
- NCT05980195
- Testing
- Hyperbaric oxygen therapy, Standard medical treatment, Risk factor management
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
Mild Cognitive Impairment, Alzheimer's Disease
Korea Alzheimer's Disease Neuroimaging Initiative
PRIMARY OBJECTIVES -Establish a registry for Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) STUDY DESIGN -This is a non-randomized, natural history, observational, registry study.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Subcortical Vascular Dementia
- Trial name
- K-ADNI (NCT01979419)
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Korean Alzheimers' Disease Neuroimaing Intitiative
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Stroke, Cognitive Impairment
Neurostimulation for Cognitive Rehabilitation in Stroke
Transcranial direct current stimulation has shown promising results in stroke patients. This study is a double blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different…
- Conditions
- Stroke, Cognitive Impairment, Cerebral Infarction
- Trial name
- NeuroCog (NCT02315807)
- Testing
- transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Paraíba
Vascular Dementia
Managing Vascular Dementia Risk Factors With SymTrend
Individuals with uncontrolled vascular disease are at risk for an insidious progression of brain injury starting in early to midlife and ultimately culminating in a vascular dementia, robbing them of activities of daily living…
- Trial name
- NCT03702543
- Testing
- SymTrend, Inc.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- SymTrend Inc.
Neuro-Degenerative Disease, Dementia
Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease
This study evaluates an educational brochure tailored to caregivers of people with Alzheimer's disease, Parkinson's disease dementia, Lewy body disease, frontotemporal dementia, and vascular disease dementia.
- Conditions
- Neuro-Degenerative Disease, Dementia, Caregiver Burnout, Alzheimer Disease
- Trial name
- Empathy (NCT04635540)
- Testing
- Educational Brochure
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Cardiac Catheterization, Electrophysiology Procedure
Post Anesthesia Care Unit (PACU) Weighted Blanket Study
This study is being conducted to evaluate the safety and efficacy of weighted blankets to reduce agitation in patients in the post-procedural phase after cardiac catheterization and electrophysiology procedures in the post…
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Trial name
- NCT05632640
- Testing
- Standard of Care, Weighted blanket
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Stroke, Brain Injuries
Clinical Effectiveness of iReadMore for People With Alexia
iReadMore will provide an app-based therapy for people with pure or central alexia. This study aims to test the clinical effectiveness of iReadMore for improving reading accuracy and speed in real world users of the therapy.
- Conditions
- Stroke, Brain Injuries, Aphasia, Alexia
- Trial name
- NCT04849091
- Testing
- iReadMore
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Stroke, Cognitive and Attention Disorders and Disturbances
The RenAtt Method for Diagnosing and Treating Attention Problems After Stroke and Brain Injury, Further Validation of RehAtt® DiSTRO Assessment of Cognitive and Visual Function
Stroke is one of the most common long-term disabilities in the world. Despite better access to more effective acute treatment, WHO reports a prediction of almost a doubling of disability-adjusted life-years (DALYs) in 2050.
- Conditions
- Stroke, Cognitive and Attention Disorders and Disturbances, Digital Health, Screening Strategy
- Trial name
- NCT07762274
- Testing
- Oxford Cognitive Screen
- Where
- 3 sites in Italy, Sweden and 1 more
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Stroke, Dementia
Prevention of Stroke and Dementia in Primary Care
In Western Countries, stroke and dementia are the main causes of long-term disability, dependency, and nursing home admission. Due to demographic trends a continuous increase of patient numbers can be expected.
- Conditions
- Stroke, Dementia, Disability
- Trial name
- INVADE (NCT01107548)
- Testing
- Systematic detection of vascular risk factors and subsequent evidence-based treatment
- Where
- Germany
- Volunteers
- 3,908 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Carotid Artery Diseases, Carotid Artery Stenosis
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
There are 10.3 million cases of stroke registered in the world every year; 63% of them lead to death. According to World Health Organization, stroke is one of the most important risk factors of death and early disability.
- Trial name
- NCT05126238
- Testing
- Lithium Carbonate
- Where
- Russia
- Volunteers
- 107 people
- Sponsor
- Negovsky Reanimatology Research Institute
Mild Cognitive Impairment
Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II
Background: Subcortical Vascular Dementia (VaD), consequent to deep brain small vessel disease (SVD), is the most frequent form of VaD.
- Trial name
- RehAtt (NCT02033850)
- Testing
- Attention Process Training-II
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi