Clinical trials: Vascular Neurocognitive Disorder
Vascular Dementia, Stroke
Cilostazol Verse Asprin for Vascular Dementia in Poststroke Patients With White Matter Lesions
The purpose of this study is to evaluate the efficacy of PDE-3 inhibitor, cilostazol, in prevention and treatment of vascular dementia, in those with brain white matter lesions and vascular risk factors.
- Trial name
- CAVAD (NCT00847860)
- Testing
- Cilostazol, Aspirin
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Myelodysplastic Syndrome, Effects of Chemotherapy
Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery
Broadly speaking, the goal of this study is to better understand the influence of chemotherapy treatment on the cognitive and neural mechanisms underlying human behavior.
- Conditions
- Myelodysplastic Syndrome, Effects of Chemotherapy, Mild Cognitive Impairment, Multiple Myeloma
- Trial name
- Chemobrain (NCT02767388)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Ischemic Stroke, Motor Deficits
Effect of Vagus Nerve Stimulation Via the Outer Ear on Motor and Cognitive Deficits After Ischemic Stroke
The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) works to treat motor and neurocognitive deficits after ischemic stroke when applied within 30 days after onset of stroke.
- Conditions
- Ischemic Stroke, Motor Deficits, Cognitive Impairment, Vagus Nerve Stimulation
- Trial name
- EVAMOS (NCT06822140)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Rheinburg-Klinik
Cerebral Small Vessel Diseases, Inflammation
INflammation and Small Vessel Disease Study
A prospective observational cohort study in patients with cerebral small vessel disease deterring whether changes in systemic inflammation predict brain white matter damage measured using MRI and cognitive decline.
- Conditions
- Cerebral Small Vessel Diseases, Inflammation, Stroke
- Trial name
- INSVD (NCT05746221)
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Cambridge
Cardiovascular Diseases, Hypertension
Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals
The overall research objective of this proposal is to determine the impact of increased daily peanut consumption on indices of neurocognitive and physiological health in BL individuals
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet
- Trial name
- NCT06318377
- Testing
- Peanut group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Sleep Disorder, Cardiovascular Diseases
Dose-effect Relationship of Tai Chi on Health Promotion in Different Age Groups
The purpose of this study is to investigate the physical and mental health status of middle-aged and elderly people of different ages and practicing Tai chi for different periods of time, so as to provide a strong theoretical…
- Conditions
- Sleep Disorder, Cardiovascular Diseases, Hypertension, Cognitive Impairment
- Trial name
- NCT06307483
- Testing
- Taichi group, Exercise group
- Where
- China
- Volunteers
- 499 people
- Sponsor
- Beijing Sport University
Ischemic Stroke, Hypertension
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI.
- Conditions
- Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes
- Trial name
- NCT05703386
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Delirium, Cerebral Infarction
the Incidence and the Association Between Motor Subtypes and Outcome of Delirium in Ischemic Stroke Patients
this study examines the incidence of newly developed delirium in patients who admit to university hospital stroke unit for cerebral infarction, and analyze the association between delirium motor subtypes and short-term outcome in…
- Trial name
- NCT03317106
- Where
- South Korea
- Volunteers
- 943 people
- Sponsor
- Chungnam National University Hospital
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Dementia, Alzheimer Disease
Making Connections Thru Music
Healthcare systems around the world, including within the United States, have long-established shortages of trained caregivers. The American Health Care Association states that "the health care system has experienced a shortage…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- MCTM (NCT06079216)
- Testing
- Volunteer Led Making Connections Thru Music, Staff Led Making Connections Thru Music
- Where
- 2 sites in United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hopeful Aging
Alzheimer Disease, Alzheimer Dementia
Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study
The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and…
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Vascular Dementia, Lewy Body Disease
- Trial name
- ACIST (NCT03724136)
- Testing
- Intravenous Bone Marrow Stem Cell (BMSC) Fraction, Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction, Near Infrared Light
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- MD Stem Cells
PSP, CBD
Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
The investigators aim to learn more about symptoms suggestive of a neurodegenerative process.
- Conditions
- PSP, CBD, PCA, LPA
- Trial name
- AND1 (NCT04680130)
- Testing
- C-11 PiB, AV1451 Tau, C-11 ER176
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Ischemic Stroke, Hemorrhagic Stroke
Observational Study on Determinants of Dementia After Stroke
The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify predictors of post stroke dementia (PSD).
- Trial name
- DEDEMAS (NCT01334749)
- Where
- 5 sites in Germany
- Volunteers
- 736 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Dementia, Alzheimer Disease
Serotonergic Pharmacotherapy for Agitation of Dementia
This study is a randomized, double-blind, placebo-controlled, fixed dose study currently being conducted on two geropsychiatric units at Western Psychiatric Institute and Clinic.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- SPAD (NCT00009204)
- Testing
- Citalopram [Celexa], Perphenazine [Trilafon]
- Where
- United States
- Sponsor
- Bruce Pollock
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Dementia, Caregiver Burnout
WeCareAdvisor Study for Caregivers of People Living With Dementia
The WeCareAdvisor is an online tool to help caregivers manage behavioral and psychological symptoms of people living with dementia.
- Conditions
- Dementia, Caregiver Burnout, Caregiver Stress Syndrome, Alzheimer Disease
- Trial name
- NCT05012410
- Testing
- Immediate treatment group with High-Intensity Prompts, Immediate treatment group with Low-Intensity Prompts, Waitlist Control after three months with High-Intensity Prompts
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Drexel University
Stroke, Cerebral Small Vessel Diseases
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study
TRIDENT Main Study: TRIDENT is a multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial of a fixed low-dose combination BP-lowering pill ("Triple Pill") strategy on top of…
- Conditions
- Stroke, Cerebral Small Vessel Diseases, Intracerebral Hemorrhage, Vascular Dementia
- Trial name
- TRIDENT-MRI (NCT03783754)
- Testing
- telmisartan 20 mg + amlodipine 2.5mg + indapamide 1.25mg
- Where
- 3 sites in Australia
- Volunteers
- 4 people
- Sponsor
- The George Institute